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Rupture mechanics of human carotid arteries

Rupture mechanics of human carotid arteries

Project Investigators: Ali Cagdas Akyildiz , Jolanda WentzelAnton van der Steen,Frank Gijsen

 

 

Rupture of vulnerable plaques can lead to acute myocardial infarctions and ischemic strokes, biomechanical modeling of the rupture mechanics has shown to provide understanding of which factors contribute mechanically to plaque vulnerability.

 

In this project, the rupture of carotid plaques is studied using Finite Element Method (FEM) computer simulations. The vessel geometry is obtained from either histology or in-vivo MRI which is then transformed into a 3D computational model. Using FEM, an internal blood pressure is proposed as a boundary condition and the internal stresses and strains are calculated. Non-linear, anisotropic mechanical material models are used. After simulations, geometric and stress analyses are performed.

 

The aim of this research is to better understand rupture mechanics of carotid plaques and work towards patient specific application in a clinical setting.