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Shear stress and plaque lipidomics

Shear stress and atherosclerotic plaque lipidomics

Investigators: Astrid Moerman, Kim van der HeidenFrank Gijsen

Atherosclerotic plaques develop at arterial sites exposed to low shear stress. When a plaque intrudes the arterial lumen, shear stress at the upstream side of the plaque increases [1]. Rupture of vulnerable plaques frequently occurs at this high shear stress exposed upstream site [2,3]. Therefore, we hypothesize that alterations in the shear stress patterns during plaque growth influence plaque composition and play a role in plaque destabilization. To analyze the correlation between shear stress and plaque composition, we will create 3D shear stress maps of human carotid arteries based on MRI data from patients scheduled to undergo carotid endarterectomy (CEA). We will analyze plaque composition by performing histology on these CEA samples, and use a 3D Histology tool to put the 2D histological sections in the 3D shear stress map.

1.  Strain distribution over plaques in human coronary arteries relates to shear stress. Gijsen FJ, Wentzel JJ, Thury A, Mastik F, Schaar JA, Schuurbiers JCH, Slager CJ, van der Giessen WF, de Feyter PJ, van der Steen AF, Serruys PW. Am J Physiol. 2008 Oct;259(4):H1608-14

2.  The role of shear stress in the destabilization of vulnerable olaques and related therapeutic implications. Slager CJ, Wentzel JJ, Gijsen FJ, Thury A, van der Wal AC, Schaar JA, Serruys PW. Nat Clin Pract. Cardiovasc Med. 2005 Sep;2(9):456-64

3.  High shear stress influences plaque vulnerability. Groen HC, Gijsen FJ, van der Lugt A, Ferguson MS, Hatsukami TS, Yuan C, van der Steen AF, Wentzel JJ. Neth Heart J. 2008 Aug;16(7-8):280-3

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