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Dr. Vos, H. (Rik)

high frame-rate echocardiographic imaging techniques.

Rik VosDr. Vos, H. (Rik )

Research area: high -rate echocframeardiographic imaging techniques.
Publications:  h.vos

Office: Ee2314
Tel:       +31 (0)10 7044042
Fax:      +31 (0)10 7044720
E-mail: h.vos@erasmusmc.nl 

 

With an MSc in Applied Physics (2004, with honours, Delft University of Technology) and a PhD in Biomedical Engineering (2010, Erasmus MC), Rik Vos has firm knowledge on medical ultrasound. He currently is an assistant professor at Biomedical Engineering, developing high frame-rate echocardiographic imaging techniques.

At Erasmus MC, he has been working on intravascular high-frequency transducers (2003-2004), ultrasound contrast agents (2004 - 2010) and high frame rate cardiovascular imaging (2013 - now). The heart and vessels are organs in which the valves, blood, and muscle have very complex dynamics with maximum velocities up to 10 m/s. The key innovation is to image and analyse these dynamics by high frame rate ultrasound (up to 5000 frames/s) for diagnostic purposes, both with and without contrast agents. In-depth knowledge of various recent high frame rate ultrasound machines [Ultrasonics, Verasonics, Zonare], data processing, ultrasound propagation and a heart failure animal model provides a firm basis for this innovative approach. A large benefit of these systems is that all high frame rate data are stored to disk, which allows off-line development of current and future data-analysis algorithms and subsequent diagnosis. As such, the method provides a huge amount of functional information, otherwise unseen with conventional echocardiography.

In parallel, he is leading scientist on a project on contrast-enhanced superharmonic ultrasound imaging of the heart, and on ultrasonic detection of rheumatic inflammation of joints. Furthermore, he is involved in the development of a 3D transesophageal echo (3D TEE) and 3D intracardiac probe, which are collaborative projects with Delft University of Technology

In an intermittent period (2010 - 2012), he has worked for the Dutch non-profit contract research organisation TNO, developing cutting-edge ultrasonic sensoring systems for corrosion monitoring. In parallel, he developed bubble detection and sizing systems and a rocket fuel monitor. Explorative research, complex multi-sensor data processing and project management were the key assets acquired.

He is leading investigator on the 1-million Euro EFFECTS project that uses a commercial 2D high frame rate system to determine cardiac stiffness for early detection of heart failure in elderly, and he is co-leading investigator on 2D high-frame rate contrast agent-enhanced abdominal aorta imaging in human volunteers. Group sizes of patient and volunteer studies are up to 60 people, which is highly feasible within the multi-disciplinary and innovation-driven Erasmus MC.

Scientific output [September 2017]:

Peer-reviewed papers:                                                    37

Of which as first author:                                     8

Of which as last author:                                     3

Last author without PhD promotors:                  1

Non-reviewed proceedings:                                            36

Patents:                                                                             2

 

Scopus h-index: 14 (August 2017)

Google Scholar h-index: 17

 

Top publications:

M. van der Ven, L.L. Van der Velden, J. Luime, J.G. Bosch, J.M.W. Hazes, H.J. Vos, “High-frame rate power Doppler ultrasound is more sensitive than conventional power Doppler in detecting rheumatic vascularisation”, Ultrasound in Medicine and Biology;43(9):1868-1879, 2017

Clinical pilot study in which we show the blood perfusion of finger joints in ten healthy volunteers and fourteen patients with rheumatic disorder, using the newest high frame rate research ultrasound machine (Verasonics Vantage-256) and data processing (singular value decomposition). This was a combined clinical and technological study with the Rheumatology department that I independently supervised from first ideas to final publication.

 

M. Strachinaru, J.G. Bosch, B.M. van Dalen, L. van Gils, A.F.W. van der Steen, N. de Jong, M.L. Geleijnse, H.J. Vos, “Cardiac shear wave elastography using a clinical ultrasound system”, Ultrasound in medicine and Biology, 43(8):1596-1606, 2017

Technological study extended with clinical case studies showing the potential feasibility of high frame rate cardiac shear wave detection, translating our laboratory and pre-clinical animal study into the clinic. This paper is the basis of our current clinical study on a large group of healthy volunteers (50+ people) and a group of 20+ patients with genetic hypertrophic cardiomyopathy.

 

K. Kooiman and H.J. Vos [both authors contributed equally], M. Versluis, N. de Jong, “Acoustic behavior of microbubbles and implications for drug delivery”, Advanced Drug Delivery Reviews (IF 12.9, top 10%), vol. 72, pp. 28 – 48, 2014 – 83x cited

 

J. Viti, F. Guidi, H.J. Vos, N. de Jong, P. Tortoli, “Detection of Contrast Agents: Plane Wave vs Focused Transmission”, IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control (IF 1.8, top quartile); 63: 203-211, 2016.

Technological papers in which we study and review the benefits of ultrasound contrast agents both for imaging the vascularity, and the implications for therapy. These are a basis of our recently-finished 2D high-frame rate contrast agent-enhanced abdominal aorta imaging in human volunteers, and therefore also is a basis for the upcoming clinical imaging in patients.

 

C. Chen, Z. Chen, D. Bera, S.B. Raghunathan, M. Shabanimotlagh, E. Noothout, Z. Chang, J. Ponte, C. Prins, H.J. Vos, J.G. Bosch, M.D. Verweij, N. de Jong, M.A.P. Pertijs, “A Front-End ASIC With Receive Sub-array Beamforming Integrated With a 32 x 32 PZT Matrix Transducer for 3-D Transesophageal Echocardiography”. IEEE Journal of Solid-State Circuits: 52(4), 994-1006, 2017.

Technological paper showing the first fully operational 3D matrix probe from the Erasmus MC / Delft University of Technology collaboration on 3D ultrasound probes. The underlying project acted as a basis for many other dedicated 3D probe projects in which I collaborate, including the currently proposed work package on the sparse-array transducer realisation.

 

RESEARCH LINES

High frame rate contrast detection

High frame rate perfusion imaging in rheumatology

Early Finding of diastolic heart Failure by EchoCardiographic Tissue Stiffness measurements (EFFECTS)

Finished PhD students

Dissertation