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Embryogenesis and early placental development

Clinical and experimental aspects

The following objectives are addressed:


A.        The significance of two- and three-dimensional real-time and colour Doppler ultrasound for the diagnosis of fetal structural anomalies and abnormal placental development in early pregnancy (in collaboration with the Dept. of Clinical Genetics);


B.        Psychological and medico-ethical aspects of late intrauterine diagnosis of lethal anomalies (>24 weeks)(in collaboration with the Depts of Medical Psychology, Bioethics and Clinical Genetics);


C.        Genetic and immunological aspects of abnormal placental development in relation to preeclampsia (also in collaboration with “Generation R”)


D.        Identification of gene-environment interactions during the preconception period and early pregnancy in the pathogenesis of congenital malformations, miscarriages, pre-eclampsia, intrauterine growth retardation and low birth weight.


Best publication 2008

Verburg BO, Jaddoe VW, Wladimiroff JW, Hofman A, Witteman JC, Steegers EA. Fetal hemodynamic adaptive changes related to intrauterine growth: the Generation R Study. Circulation. 2008;117:649-59.


Publications 2007

Publications 2008

Publications 2009


Personnel involved

Prof.dr. E.A.P. Steegers

Mw. Prof. dr. R.P.M. Steegers-Theunissen

Mw. Dr. N.T.C. Ursem

Mw. S.A. Obermann- Borst

Mw. A.M. Oosterbaan

Mw. S. Timmermans

Mw. K. Wijnands

Mw. N. Bergen

Mw. N. van Mil

J. Twigt

Mw. M. Both 


Mw. E. van Uitert