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Infertility

Treatment, Genetics and Prevention

 

In order to identify predictors for successful fertility treatments the subdivision of Reproductive Medicine investigates the relationship between follicle development and genetic, epigenetic, hormonal and environmental factors.

 

Research lines:

 

Anovulatory infertility: Classification of anovulatory infertility. Evidence based approach on anovulatory infertility i.e. prediction of treatment and pregnancy outcome. Prevention and treatment of obesity, metabolic syndrome, cardio vascular risks and diabetes in these women.
Early follicle development: Research on regulation of early follicle development with special emphasis on the derangement of normal follicle development in polycystic ovary syndrome (PCOS) and (premature) menopause. Clinical research is focussing in the incidence of infertility after childhood cancer treatment and prevention of ovarian dysfunction after cancer therapy during childhood and adulthood (within LATER patient groups).
Genetics of Infertility: Focus on the genetic base of complex diseases like PCOS and WHOII anovulatory infertility as well as premature ovarian failure. To this end we are using genome wide association technology and micro-arrays as well a candidate gene approach in the general, patient, and founder populations.
Pregnancy outcome after ART: Strategies for optimising patient selection as well as singleton pregnancies after ovulation induction. Cost effectiveness of different ovulation induction strategies. Optimisation and simplification of IVF treatment and it’s perinatal as well as maternal outcome.
Early Embryo Development and Early Stem Cell Development: Identification of underlying mechanisms for the lack of accuracy of chromosome segregation both during meiosis as well as during cleavage divisions in embryos in relation to oocyte and embryo quality. Additional research is aimed at identifying signalling pathways involved in regulation of pluripotency and differentiation such as X chromosome inactivation within the developing human blastocysts.
 

 
Best publications 2009 
 

Female Meiotic Sex Chromosome Inactivation in Chicken
Sam Schoenmakers, Evelyne Wassenaar, Jos W. Hoogerbrugge, Joop S. E. Laven, J. Anton Grootegoed, Willy M. Baarends
PLoS Genetics, 1 May 2009, Volume 5

 

Loci at chromosomes 13, 19 and 20 influence age at natural menopause
Lisette Stolk, Guangju Zhai, Joyce B J van Meurs, Michael M P J Verbiest, Jenny A Visser, Karol Estrada, Fernando Rivadeneira, Frances M Williams, Lynn Cherkas, Panos Deloukas, Nicole Soranzo, Jules J de Keyzer, Victor J M Pop, Paul Lips, Corinne E I Lebrun, Yvonne T van der Schouw, Diederick E Grobbee, Jacqueline Witteman, Albert Hofman, Huibert A P Pols, Joop S E Laven, Tim D Spector & Andre G Uitterlinden 
Nature Genetics 2009 41:6: pp645 – 647

 

X Chromosome Inactivation Is Initiated in Human Preimplantation Embryos
Ilse M. van den Berg, Joop S.E. Laven, Mary Stevens, Iris Jonkers, Robert-Jan Galjaard, Joost Gribnau and J. Hikke van Doorninck.
American Journal Human Genetics June 12, 2009; pp84:6:

 

Publications 2007 

Publications 2008

Publications 2009 

 

Personnel involved

 Evelyne van Uitert

Dr. J. Hikke van Doorninck

 Dr. Esther B. Baart