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Paramyxoviruses

The family Paramyxoviridae contains several viruses that cause disease in humans, including measles virus (MeV), human respiratory syncytial virus (HRSV), human metapneumovirus (HMPV), mumps virus, the para-influenza viruses, and Nipah and Hendra virus.

Figuur 4 paramyxos

rHRSV-EGFP infection in bronchus of a cotton rat.
See Lemon et al., J Virol 89:2849, 2015

The overall aim of the workgroup Paramyxoviruses of the Department of Viroscience of the Erasmus MC is to understand paramyxovirus pathogenesis, i.e. how infections with paramyxoviruses lead to disease, both in humans and in animals. In addition, we investigate innate and adaptive host immune responses to paramyxovirus infection, with the aim to develop novel intervention strategies.

In close collaboration with several external partners, we have used recombinant paramyxoviruses expressing fluorescent reporter proteins to study viral pathogenesis using both in vitro and in vivo models. These studies focus on virus tropism (i.e. what cells are infected) and the role of virus-specific humoral and cellular immune responses in protection or disease enhancement. Virus-host interactions and immune correlates of protection are further studied using molecular biology, virology, genetic and bioinformatic tools. The results are used to develop novel antivirals, vaccines or vaccination strategies.


Ongoing research projects

The Paramyxoviruses workgroup of the Department of Virology of the Erasmus MC has five ongoing research projects:

  • Measles Virus Tropism
  • Measles Immune Suppression
  • Measles Vaccination
  • Animal Morbilliviruses
  • Human Metapneumovirus
  • Get to know these research projects and studies by scrolling down.  

 

Measles virus tropism

Research team:

Dr. Rik L. De Swart, PhD
Dr. Rory D. De Vries, PhD
Brigitta M. Laksono (PhD student)
Anouskha Comvalius, MsC

Figuur 3 paramyxos

Schematisch overzicht van de manier waarop een persoon kan worden geïnfecteerd met mazelen virus (links) en het virus vervolgens ongeveer twee weken later weer uitscheidt (rechts).

Uit: De Vries en De Swart. Measles virus: a respiratory virus causing systemic disease. Chapter 26 in: Human respiratory viral infections, edited by Sunit Singh. CRC Press, 2014.

Selection of publications:

  

Measles immune suppression

Research team:

Dr. Rik L. De Swart, PhD
Dr. Rory D. De Vries, PhD
Brigitta M. Laksono (PhD student)
Anouskha Comvalius, MsC

Selection of publications:    

  

Measles vaccination

Research team:

Dr. Rik L. De Swart, PhD
Dr. Rory D. De Vries, PhD
Anouskha Comvalius, MsC

Selection of publications:

  

Animal morbilliviruses

Research team:

Dr. Rik L. De Swart, PhD
Prof. Thijs Kuiken, PhD
Dr. Rory D. De Vries, PhD
Anouskha Comvalius, MSc
Marco van de Bildt, BsC

Figuur 2 paramyxos

Infection of non-human primates with rMV-EGFP. At the peak of virus replication fluorescent cells can be detected in all lymphoid tissues, including lymph nodes (A), gut-associated lymphoid tissue (B) and Peyer’s patches (C and D).

Uit: De Vries et al., PLoS Pathog 8: e1002885, 2012.
  

Selection of publications:


 

Respiratory syncytial virus

Research team:

Dr. Rik L. De Swart, PhD
Dr. Bernadette G. van den Hoogen, PhD
Dr. Pieter L. Fraaij, MD, PhD
Dr. Jeroen van Kampen, MD, PhD
Laurine Rijsbergen, MSc
Stefan van Nieuwkoop, BsC  

Figuur 5a paramyxos Figuur 5b paramyxos

Fluorescence microscopy images of rHRSV-EGFP infection in lung (left) or nose (right) of cotton rats.
See Lemon et al., J Virol 89:2849, 2015

Selection of publications:

  

Human metapneumovirus

  
Research team:

Dr. Bernadette G. Van den Hoogen, PhD
Prof. Ron A.M. Fouchier, PhD
Dr. Rik L. De Swart, PhD
Stefan van Nieuwkoop, Bsc  

Publications: