What we do
About our project
Data from the CHECK study will be used. Inclusion in this cohort started more than ten years ago and at baseline the 1002 cohort participants (age 45-65) had to have recent onset non-traumatic pain and/or stiffness of knee and/or hip. At baseline, all participants were examined by a physician of the participating research centres, blood samples were drawn, a baseline questionnaire was administered, and patients underwent standardised multi angle x-ray examination of hip and knee joints.
For each participant with baseline knee symptoms, a set of clinical experts from primary and secondary care will evaluate the presence of clinically relevant knee osteoarthritis 5 to 10 years after baseline, based on the clinical and radiographic data collected within the CHECK study. For each participant with baseline hip symptoms, clinical experts will evaluate the presence of clinically relevant hip osteoarthritis.
Baseline demographics, questionnaire data, data from physical examinations, radiographic data, and hsCRP will be used to construct a diagnostic model against the presence of clinically relevant osteoarthritis 5 to 10 years after baseline.
For each participant with baseline knee symptoms, a set of clinical experts from primary and secondary care will evaluate the presence of clinically relevant knee osteoarthritis 5 to 10 years after baseline, based on the clinical and radiographic data collected within the CHECK study. For each participant with baseline hip symptoms, clinical experts will evaluate the presence of clinically relevant hip osteoarthritis.
Baseline demographics, questionnaire data, data from physical examinations, radiographic data, and hsCRP will be used to construct a diagnostic model against the presence of clinically relevant osteoarthritis 5 to 10 years after baseline.
Our research focus
Project aims:
- Develop models based on baseline factors
- Compare predictive abilities to the existing ACR-criteria
- Externally validate models based on baseline factors
- Develop models based on the course of signs and symptoms during the first two years of follow-up
- Externally validate models based on the course of signs and symptoms
- Implement clinically relevant models into primary care
Funds & Grants
Dutch Arthritis Society (15-1-301).
Collaborations
Prof.dr. Kloppenburg, Dept. Rheumatology, Leiden University Medical Center
Prof.dr. Boers, Dept. Rheumatology, VU Medical Center Amsterdam
Prof.dr. Bijlsma, Dept. Rheumatology, University Medical Center Utrecht
Prof.dr. Boers, Dept. Rheumatology, VU Medical Center Amsterdam
Prof.dr. Bijlsma, Dept. Rheumatology, University Medical Center Utrecht
Our team
Dr. J. Runhaar (co-promotor), j.runhaar@erasmusmc.nl
Qiuke Wang, q.wang@erasmusmc.nl
Ömer Özbulut, o.ozbulut@erasmusmc.nl
Prof. S.M.A. Bierma-Zeinstra (promotor), s.bierma-zeinstra@erasmusmc.nl
Contact address for the project: j.runhaar@erasmusmc.nl.
