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A.M.I.A. (Anouk) van Alphen


  • Department
  • Ear, Nose and Throat (ENT)



In February 2021 I started my PhD at the department of ENT, after obtaining my medical degree in 2020. Previously, I worked as a resident at the Anesthesiology department. My current research focusses on Value Based Healthcare and prioritizing surgical capacity in times of scarcity.

Recent Findings 

Previous studies in the lab have shown that autologous dendritic cells pulsed with allogenic tumor cell lysate was able to induce peripheral T cell activation and tumor-reactive T cell responses in patients with mesothelioma and pancreatic cancer. Current research focuses on how to initiate an effective immune response in the tumor as well as the tumor-draining lymph node using dendritic cell vaccination. Furthermore, we are studying novel approaches for (personalized) vaccination. In addition, we have identified T cell characteristics that underlie clinical efficacy of immune check inhibitors or chemotherapeutic agents in mesothelioma. The selected publications below give an impression of our work.