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Researcher

A. Boonstra, PhD

Associate Professor

  • Department
  • Gastroenterology & Hepatology
  • Focus area
  • The main focus of the research group is to better understand the mechanisms that are responsible for liver disease caused by infections with hepatitis viruses (HBV, HCV, HEV), and to determine markers that predict the development of liver cancer. The research benefits from extensive expertise on small-animal models, genomics/bio-informatics, and immunology of infectious diseases, as well as biomarker technology.
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About

Introduction

André Boonstra received his PhD at the Erasmus MC in Rotterdam. His postdoctoral training as an immunologist on infectious diseases was at the DNAX Research Institute (Palo Alto, USA) and the National Institute for Medical Research Mill Hill (London, UK). Since September 2006 he is heading the viral hepatitis research group at the Department of Gastroenterology and Hepatology of the Erasmus MC. 
 

Field(s) of expertise

The main focus of the research group is to better understand the mechanisms that are responsible for liver disease caused by infections with hepatitis viruses (HBV, HCV, HEV), and to determine markers that predict the development of liver cancer.  

The research benefits from extensive expertise on small-animal models, genomics/bio-informatics, and immunology of infectious diseases, as well as biomarker technology.

 

Publications

1. Debes JD, van Tilborg M, Groothuismink ZMA, Hansen BE, Schulze zur Wiesch J, von Felden J, de Knegt RJ, Boonstra A. Serum immune signatures associated with HCC development in DAA-treated HCV patients. Gastroenterology. 2018. Feb; 154(3):515-517. 

2. Boeijen LL, Montanari NR, de Groen RA, van Oord GW, van der Heide M, de Knegt RJ, Boonstra A. Mucosal-associated invariant T (MAIT) cells are more activated in chronic hepatitis B, but not depleted in blood: reversal by antiviral therapy. J Inf Dis. 2017. 216(8):969-976.

3. Van de Garde M, Pas SD, van Oord GW, Gama L, Choi Y, de Man RA, Boonstra A, Vanwolleghem T. Interferon-alpha treatment rapidly clears Hepatitis E virus infection in humanized mice. Scientific Reports. 2017. 7(1):8267.

4. Spaan M, Claassen MA, Hou J, Janssen HLA, de Knegt RJ, Boonstra A. The intrahepatic T-cell compartment does not normalize years after therapy-induced hepatitis C virus eradication. J Inf Dis. 2015. 212(3): 386-390.

5. Vanwolleghem T, Hou J, van Oord G, Andeweg AC, Osterhaus ADME, Pas SD, Janssen HLA, Boonstra A. Re-evaluation of HBV clinical phases by system biology identifies unappreciated roles for the innate immune response and B cells. Hepatology. 2015. 62(1): 87-100. 
 

Other positions

Andre Boonstra contributed to the scientific community by publishing more than 100 research papers and several book chapters, and has been member of advisory boards for Pharma and NIH committees. He is a member of International Coalition for Elimination of HBV (ICE-HBV) and the HBV Forum. 
 

Scholarships, grants, and awards

Andre Boonstra is coordinator of the EU Horizon 2020 grant ESCALON. Together with Jose Debes, he leads the European-South American Collaboration for Assessment of Liver Originated Neoplasia (ESCALON) aimed at improving early detection and diagnosis of cancer to the liver, the bile ducts and the gall bladder.
In addition, he received research grants from various pharmaceutical companies, the Dutch government, and from NWO-ZonMW. 
 

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