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Researcher

A.E.J.A. (Amy) Broeders, MSc

Research Technician

  • Department
  • Surgery
  • Focus area
  • Improving in vitro 3D liver and cholangiocarcinoma (CCA) organoid models.
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About

Introduction

I am a Biomedical Engineer with a special interest in the topic of regenerative medicine. During my studies, I developed interest in the interactions between cells and biomaterials, and how this can contribute to regeneration within the human body. During my Master thesis and internship, I already got familiar with (kidney) organoid culture in combination with various types of biomaterials. Currently, as a Research Technician at the Laboratory of Experimental Transplantation and Intestinal Surgery (LETIS), my own project focuses on improvement of the 3D cholangiocarcinoma (CCA) organoid model. In addition to that, I am involved in organoid initiation from both donor- and patient-derived (liver) tissues, and general lab tasks to support our group.

Field(s) of expertise

As a Research Technician, I mostly work on organoid initiation from both donor- and patient-derived tissues, and general lab tasks. In addition, my own project focuses on improvement of the 3D cholangiocarcinoma (CCA) organoid model.

Education and career

I obtained both my Bachelor’s (2016-2019) and Master’s (2019-2022) degree in Biomedical Engineering at Eindhoven University of Technology. During my Master, I specialized in the direction of Regenerative Medicine and Technology, and mainly followed courses about biomaterials and tissue regeneration. For my Master thesis, I worked on setting up a solid base of biomaterial-driven differentiation of iPSCs into late primitive streak cells, aiming to develop a platform for further differentiation of these cells and organoid culture. In addition, during my internship at Radboudumc Nijmegen, I worked on a project aiming to improve the differentiation of induced pluripotent stem cells (iPSCs) towards podocytes using different biomaterials, including both synthetic and decellularized matrices.

In 2023, I started my scientific career as a Research Technician at the Laboratory of Experimental Transplantation and Intestinal Surgery (LETIS), Department of Surgery, Erasmus Medical Center Rotterdam. Under supervision of prof. Luc van der Laan and Monique Verstegen, PhD, I mostly work on organoid initiation from both donor- and patient-derived tissues, general lab tasks, and for my own project on improvement of the 3D cholangiocarcinoma (CCA) organoid model.

Amy on LinkedIn

My Groups

Laboratory of Experimental Transplantation and Intestinal Surgery (LETIS)

The Laboratory of Experimental Transplantation and Intestinal Surgery (LETIS) is part of the Department of Surgery and works in close collaboration with the Department of Gastroenterology & Hepatology. We have a strong focus on translational research in the field of regenerative medicine, organ transplantation, liver disease and liver cancer. The research aims to provide basic and applied knowledge using organoids, bio-scaffolds, animal models, and organ perfusion technologies.

Related

Research groups/labs

Laboratory of Experimental Transplantation and Intestinal Surgery (LETIS)