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Researcher

M. (Michela) Maresca, PhD

Postdoc

  • Department
  • Clinical Genetics
  • Focus area
  • My work explores human genetics and the regulation of neural function and development, with a focus on gene regulation, chromatin and epigenetic control. I develop and apply advanced genomic and molecular assays to dissect the molecular logic underlying health and disease, bridging basic mechanisms with biomedical relevance.
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About M. (Michela) Maresca, PhD

Introduction

I am a postdoctoral scientist with a broad interest in understanding cellular regulation and human genetics. My research aims to uncover the mechanisms that define and maintain cell identity, and how their disruption contributes to disease development. I am passionate about interdisciplinary approaches and novel assay development. 

Field(s) of expertise

Expertise in functional genomics, epigenetic regulation, dynamics of gene regulation and cell function in multicellular systems and cell models of development (including the brain).

Education and career

Bachelor's degree in Biotechnologies for health, from Napoli (Italy). 

Master in Molecular Medicine, from Uppsala University.

PhD at NKI-AVL, University of Amsterdam

Publications

Liu, N. Q., Maresca, M., van den Brand, T., Braccioli, L., Schijns, M. M., Teunissen, H., ... & de Wit, E. (2021). WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation. Nature genetics, 53(1), 100-109.

Maresca, M., van den Brand, T., Li, H., Teunissen, H., Davies, J., & de Wit, E. (2023). Pioneer activity distinguishes activating from non‐activating SOX2 binding sites. The EMBO journal, 42(20), e113150.

Maresca, Michela, et al. "Pioneer activity distinguishes activating from non-activating pluripotency transcription factor binding sites." bioRxiv (2022): 2022-07.

Maresca, M., Liu, N. Q., & de Wit, E. (2022). Acute protein depletion strategies to functionally dissect the 3D genome. In Spatial Genome Organization: Methods and Protocols (pp. 311-331). New York, NY: Springer US.

 

Complete publication list 

 

 

Teaching activities

Supervision of students

Other positions

Board member of the postdocs network at Erasmus MC

Related

Departments and research centers

Genetic Identification logo

Clinical genetics

Research Projects

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Child Brain Lab

The Child Brain Lab is a testing facility for brain development and brain function of children with neurological or psychiatric disorders or disorders of head and senses. Data are used to facilitate clinical care and to establish developmental growth curves, thereby providing a solid infrastructure for evaluating new techniques and interventions. The Child Brain Lab is the linking pin between value-based health Care and scientific research.