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Profile picture Annemarie van Rossum
Researcher

A.M.C. (Annemarie) van Rossum, PhD

Principal investigator

  • Department
  • Pediatrics
  • Focus area
  • Pediatrics, division of Pediatric Infectious Diseases and Immunology
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About

Introduction

Annemarie van Rossum is professor of Paediatric Infectious Diseases. She obtained her MD and PhD (cum laude) at the Erasmus University Rotterdam (prof. R.de Groot).

From 2004 - 2005 she was a research fellow at the Weiser laboratory of the department of Microbiology (Prof. J.N. Weiser) of the University of Pennsylvania, Philadelphia, USA.

From 2009 - 2011 she was trained in Paediatric Infectious Diseases and Immunology in Rotterdam. She received several personal grants to start a translational researchline on respiratory tract infections caused by Mycoplasma pneumoniae. At the same time she started an international intervention trial on early onset neonatal sepsis together with M. Stocker, head of the PICU in Luzern, Switzerland, that was published in the Lancet in 2017 (www.nest-net.org).

Her two current researchlines focus on respiratory (specifically M. pneumoniae infections) and neonatal infections aiming to develop innovative diagnostic tools to guide appropriate treatment and prevent antibiotic resistance through targeted treatment.

Field(s) of expertise

My research focusses on better understanding of two common bacterial infections (pneumonia and neonatal sepsis), and aims to develop innovative diagnostic tools that support clinicians to prescribe antibiotics appropriately which is essential in this era of alarming antibiotic resistance. During previous years I received several personal grants to build my own research group.

Education and career

2018 - present Professor of Pediatric Infectious Diseases.

2014 - present Vice Chair of Pediatrics. 

2012 - 2018: Head of the division of Pediatric Infectious Diseases, Immunology and Rheumatology, Erasmus MC/Sophia Children’s Hospital, Rotterdam. 

2011 - present Pediatrician, Infectious Diseases and Immunology specialist.

2009 - 2011: Fellow Infectious Diseases and Immunology, Erasmus Medical Center/Sophia Children’s Hospital, Rotterdam.

2007 - 2009: General pediatrician, Division of general pediatrics, Erasmus Medical Center/Sophia Children’s Hospital, Rotterdam.

2004 - 2005: Research fellow, University of Pennsylvania, Philadelphia, USA.

2001 - 2007: Resident in Pediatrics, Erasmus Medical Center/Sophia Children’s Hospital, Rotterdam, and Medical Center Rijnmond, Rotterdam. 

2002: PhD Cum laude "Challenges in the treatment of HIV-1 infected children with highly active antiretroviral therapy".

1998 - 2001: PhD student Erasmus Medical Center/Sophia Children’s Hospital, Rotterdam. Dept of Pediatrics, division of Infectious Diseases/Immunology.

Publications

List of 5 top publications:

Efficacy and Safety of Procalcitonin-Guided Decision Making in Neonates Suspected of Early Onset Sepsis: The Neopins Study—An International, Multicenter Non-Inferiority Randomized Controlled Intervention Trial.
Wendy Van Herk, MD, Martin Stocker, MD, Salhab El Helou, MD, Matteo Fontana, MD, Frank a.B.a. Schuerman, MD, H.K. Van Den Tooren, MD, Jantien Bolt, MD, Jan Janota, MD, Laura H. Van Der Meer, MD, Rob Moonen, MD, Sintha D. Sie, MD PhD, Esther De Vries, MD, Albertine Donker, MD, Urs Zimmermann, MD, Luregn G. Schlapbach, MD PhD, Amerik C. De Mol, MD PhD, Angelique Haringsma, MD, Roy Madan, MD, Maren Tomaske, MD, Rene F. Kornelisse, MD PhD, Juliette Van Gijsel, MD, Eline G. Visser, Drs, Sten P. Willemsen, Drs, Wim Hop, Ir, Annemarie M.C. Van Rossum, MD, PhD. (2016). Lancet in press 2017. (IF 44, Q1, top 10%).

Antibody Responses to Mycoplasma pneumoniae: Role in Pathogenesis and Diagnosis of Encephalitis?
Patrick M. Meyer Sauteur, Bart C. Jacobs, Emiel B. M. Spuesens, Enno Jacobs, David Nadal, Cornelis Vink, and Annemarie M. C. van Rossum. (2014). PLoS Pathog. 2014 Jun; 10(6): e1003983.

Carriage of Mycoplasma pneumoniae in the upper respiratory tract of symptomatic and asymptomatic children: an observational study.
Emiel B M Spuesens, Pieter L A Fraaij, Eline G Visser, Theo Hoogenboezem, Wim C J Hop, Léon N A van Adrichem, Frank Weber, Henriette A Moll, Berth Broekman, Marjolein Y Berger, Tineke van Rijsoort-Vos, Alex van Belkum, Martin Schutten, Suzan D Pas, Albert D M E Osterhaus, Nico G Hartwig, Cornelis Vink, Annemarie M C van Rossum. (2013). Comparative Study PLoS Med. 2013;10(5):e1001444.

Procalcitonin as an early marker of infection in neonates and children.
A M C van Rossum, R W Wulkan, A M Oudesluys-Murphy. (2004). Lancet Infect Dis. 2004 Oct;4(10):620-30.

Efficacy of highly active antiretroviral therapy in HIV-1 infected children.
Annemarie MC van Rossum, Pieter LA Fraaij, Ronald de Groot. (2002). VOLUME 2, ISSUE 2, P93-102, FEBRUARY 01, 2002.

Complete overview on PubMed.

Teaching activities

Focusses on post graduate teaching, teaching in pediatric infectious diseases for paediatricians on a local, national and international level, and skills for clinician-scientists. Teaching for medical students, clinical rounds for interns and residents in paediatrics, and supervising medical students during shifts and during their research rotation.

Co-founded TULIPS (training upcoming leaders in pediatric science), a training program for clinician scientists in Child Health that is running successfully for 7 years.

Other positions

2016 - present University of Oxford, tutor and examination assessor for the postgraduate MSc program Pediatric Infectious Diseases (chair prof. A. Pollard, University of Oxford).

2016 - present Workgroup leader Postgraduate school Molecular Medicine Erasmus MC University Medical Center Rotterdam, the Netherlands.

2012 - present Deputy educator (plaatsvervangend opleider) in Pediatric Infectious Diseases and Immunology appointed by the Dutch Pediatric Association (NVK).

2013 - 2017 Committee for Scientific Affairs and Awards of the European Society for Pediatric Infectious Diseases.

2015 - present Associate editor Journal of Infection, Infection and Immunity supplement.

2015- present Associate editor Frontiers in Microbiology, Infectious Diseases specialty section.

2015 - present Member advisory board on antibiotic resistance health care networks for the ministery of health, The Netherlands.

2012 - present Member of the Erasmus MC multidisciplinary antibiotics committee.

Scholarships, grants, and awards

Awards

2012: International Investigator Award of the Infectious Diseases Society of America, special honor of the Pediatric Infectious Diseases Society of America (San Diego, USA).

2008: ZonMW (Dutch Scientific Organization, NWO) Clinical Fellowship “Colonization and infection of the respiratory tract by Mycoplasma pneumoniae in children”.

2008: Fellowship Award of the European Society of Pediatric Infectious Diseases “Colonization and infection of the respiratory tract by Mycoplasma pneumoniae in children”.

2007: ErasmusMC Fellowship Award “Colonization and infection of the respiratory tract by Mycoplasma pneumoniae in children”.

2004: TALENT-fellowship from the Netherlands Organization for Scientific Research (NWO) “Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model”.

2004: Fellowship award from the dr. Saal van Zwanenbergstichting.

2004: ESCMID award for Training in Foreign Laboratories of the European Society of Clinical Microbiology and Infectious Diseases.

2002: Young Investigators Award from the Dutch Society of Pediatrics.

2002: Research Award from the Erasmus University Rotterdam, The Netherlands (€ 7000).

2002: PhD degree, cum laude.

Grants

2008: ZonMW (Dutch Scientific Organization, NWO) Clinical Fellowship (€ 160.000) “Colonization and infection of the respiratory tract by Mycoplasma pneumoniae in children”.

2004: TALENT-fellowship from the Netherlands Organization for Scientific Research (NWO) ($ 22.000) “Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model”.

2016: Stichting Coolsingel (€ 46.980) “Nieuwe diagnostische test voor bacteriële longontsteking: een diagnostische doorbraak bij behandeling van longontstekingen?”.

2014: Sophia Foundation (€ 141.000) “New diagnostic tool for Mycoplasma pneumoniae respiratory infection: a diagnostic breakthrough in pneumonia?”.

2012: Thrasher Research Fund grant, USA ($ 170.000) “Neonatal Procalcitonin Intervention Study (NeoPInS)”.

2011: Sophia Foundation (€ 120.000) “Reducing the use of antibiotics in neonates suspected of early-onset sepsis with unchanged outcome: an international prospective randomized procalcitonin intervention study”.

2011: “Fonds Nuts-Ohra zorgsubsidies” (€ 156.000) “Veilig verkorten van de opnameduur van pasgeborenen die verdacht worden van infectie: voorkómen van een valse start voor moeder en kind”.

2008: Sophia Foundation (€ 300.000) "Colonization and infection of the respiratory tract by Mycoplasma pneumoniae in children“.

2007: ErasmusMC Fellowship Award (€ 400.000) “Colonization and infection of the respiratory tract by Mycoplasma pneumoniae in children”.

2008: Fellowship Award of the European Society of Pediatric Infectious Diseases (€ 80.000) “Colonization and infection of the respiratory tract by Mycoplasma pneumoniae in children”.

My Groups