Jump to top menu Jump to main menu Jump to content
Research project


Status: Ongoing project

In this international study the effect of personalized medication alerts on the quality of life of patients in the last phase of life is investigated.

What we do

About our project

Medication management for patients in the last phase of life is regularly underperformed. Many symptoms contributing to the quality of life are often underreported and about 83-97% of the patients use multiple potentially inappropriate medications (PIMs). Medications can become potentially inappropriate due to, for example, changed treatment objectives because of a limited life expectancy. Up to now, few research have been done to the discontinuation of medication and overall symptom management in patients in the last phase of life.

The iLIVE medication study is an international, multicentre, uncontrolled before-after study in which a clinical decision support system (CDSS) generates alerts on medication management. The aim of the study is to examine whether the use of the CDSS contributes the quality of life of patients and if it contributes to create awareness among physicians and support them in medication management. The medication alerts are based on scientific literature, currently available guidelines and pharmacological insights. This study is part of a larger international cohort study, the iLIVE project, which investigates the concerns, expectations and preferences for care of patients with a limited life expectancy and their relatives.

Our research focus

  • Patients’ quality of life
  • Palliative Care
  • Medication Optimization
  • Potentially inappropriate medication
  • Clinical Decision Support System

Funds & Grants

This project is supported by the European Union Horizon2020 program.


Collaborations within the Erasmus MC

  • Department of Public health, research group: medical decisions in end-of-life care
  • Department of pulmonology: Longgeneeskunde Erasmus MC


Collaborations outside of Erasmus MC


International collaboration

  • Switzerland
  • Sweden

Our team

  • Carin van der Rijt
  • Eric Geijteman
  • Agnes van der Heide
  • Hugo van der Kuy
  • Iris Pot
  • Marte van Hylckama Vlieg