About our research group/lab
Our research
Our focus
The main clinical symptoms caused by exotic viral infections are encephalitis, infection of the brain tissue, and haemorrhagic fever. The EVI Study Group for Exotic Viral Infections therefore focusses mainly on these two important clinical manifestations.
How do we perform this research?
The research within the study group Exotic Viral Infections is characterized by its translational nature, a patient-oriented question is translated into a basic research question and vice versa: the translation from the laboratory back to the patient, in other words: 'from bench to bedside and vice versa'. The research focusses on the relationship between the different viruses and the inflammatory and coagulation cascade; a relationship which is important in the development of disease.
What is our motivation
Infectious diseases still - and increasingly - form a major health risk, not only in less developed countries but also to an increasing extent in developed countries, including the Netherlands. The illusion that infectious diseases have practically been banned from the world was abandoned by us more than thirty years ago. That illusion was created because of an underestimation of the complex dynamics between infectious diseases, man and the environment, in combination with an overestimation of the power of our knowledge, knowledge acquired from science.
Our projects
Ongoing research projects
The Exotic Viral Infections group of the department of Virology has four ongoing research projects:
- Semester studies
- Trevi studies
- COVA study
- Hi Temp study
Key Publications
Selection of publications:
- Hepatitis E virus infection among blood donors in the South Caribbean: is screening warranted?
Schreuder I, Limper M, Gerstenbluth I, Osterhaus AD, van Veen MG, Scherbeijn SM, van Gorp EC, Duits AJ.
Neth J Med. 2016 Jan;74(1):51-3. - Emerging Viruses in the Republic of Suriname: Retrospective and Prospective Study into Chikungunya Circulation and Suspicion of Human Hantavirus Infections, 2008-2012 and 2014.
Goeijenbier M, Aron G, Anfasa F, Lundkvist Å, Verner-Carlsson J, Reusken CB, Martina BE, van Gorp EC, Resida L.
Vector Borne Zoonotic Dis. 2015 Oct;15(10):611-8. - Markers of endothelial cell activation and immune activation are increased in patients with severe leptospirosis and associated with disease severity.
Goeijenbier M, Gasem MH, Meijers JC, Hartskeerl RA, Ahmed A, Goris MG, Isbandrio B, Schuller SS, Osterhaus AD, Martina BE, van Gorp EC, Nally JE, Wagenaar JF.
J Infect. 2015 Oct;71(4):437-46. - Effect of Puumala hantavirus infection on human umbilical vein endothelial cell hemostatic function: platelet interactions, increased tissue factor expression and fibrinolysis regulator release.
Goeijenbier M, Meijers JC, Anfasa F, Roose JM, van de Weg CA, Bakhtiari K, Henttonen H, Vaheri A, Osterhaus AD, van Gorp EC, Martina BE.
Front Microbiol. 2015 Mar 24;6:220. - Time since onset of disease and individual clinical markers associate with transcriptional changes in uncomplicated dengue.
van de Weg CA, van den Ham HJ, Bijl MA, Anfasa F, Zaaraoui-Boutahar F, Dewi BE, Nainggolan L, van IJcken WF, Osterhaus AD, Martina BE, van Gorp EC, Andeweg AC.
PLoS Negl Trop Dis. 2015 Mar 13;9(3) - Safety and immunogenicity of a modified-vaccinia-virus-Ankara-based influenza A H5N1 vaccine: a randomised, double-blind phase 1/2a clinical trial.
Kreijtz JH, Goeijenbier M, Moesker FM, van den Dries L, Goeijenbier S, De Gruyter HL, Lehmann MH, Mutsert Gd, van de Vijver DA, Volz A, Fouchier RA, van Gorp EC, Rimmelzwaan GF, Sutter G, Osterhaus AD.
Lancet Infect Dis. 2014 Dec;14(12):1196-207. - Ebola virus disease: a review on epidemiology, symptoms, treatment and pathogenesis.
Goeijenbier M, van Kampen JJ, Reusken CB, Koopmans MP, van Gorp EC.
Neth J Med. 2014 Nov;72(9):442-8. - Hyperferritinaemia in dengue virus infected patients is associated with immune activation and coagulation disturbances.
van de Weg CA, Huits RM, Pannuti CS, Brouns RM, van den Berg RW, van den Ham HJ, Martina BE, Osterhaus AD, Netea MG, Meijers JC, van Gorp EC, Kallas EG.
PLoS Negl Trop Dis. 2014 Oct 9;8(10):e3214. - The hanta hunting study: underdiagnosis of Puumala hantavirus infections in symptomatic non-travelling leptospirosis-suspected patients in the Netherlands, in 2010 and April to November 2011.
Goeijenbier M, Hartskeerl RA, Reimerink J, Verner-Carlsson J, Wagenaar JF, Goris MG, Martina BE, Lundkvist Å, Koopmans M, Osterhaus AD, van Gorp EC, Reusken CB.
Euro Surveill. 2014 Aug 14;19(32). - Serum angiopoietin-2 and soluble VEGF receptor 2 are surrogate markers for plasma leakage in patients with acute dengue virus infection.
van de Weg CA, Pannuti CS, van den Ham HJ, de Araújo ES, Boas LS, Felix AC, Carvalho KI, Levi JE, Romano CM, Centrone CC, Rodrigues CL, Luna E, van Gorp EC, Osterhaus AD, Kallas EG, Martina BE.
J Clin Virol. 2014 Aug;60(4):328-35. - Activation of coagulation and tissue fibrin deposition in experimental influenza in ferrets.
Goeijenbier M, van Gorp EC, Van den Brand JM, Stittelaar K, Bakhtiari K, Roelofs JJ, van Amerongen G, Kuiken T, Martina BE, Meijers JC, Osterhaus AD.
BMC Microbiol. 2014 May 30;14:134.
Collaborations
Our team
Semester studies
- Prof. Eric C.M. van Gorp
- Dr. Marco Goeijenbier MD Msc
- Wesley de Jong MD
- Thomas Langerak MD
- Laura Doornekamp MD
- Dr. Kirsten Adriani MD PhD
Trevi studies
- Prof. Eric C.M. van Gorp
- Lennert van den Dries MD
- Rob Gruters
- Marlies Wagener
- Stefanie van Opstal
COVA study
- Prof. Eric C.M. van Gorp
- Dr. M. Goeijenbier MD Phd Msc
- W. de Jong MD
- L. Doornekamp MD
- R. Gruters
Hi Temp study
- Prof. Eric C.M. van Gorp
- Dr. Maarten Limper MD PhD
- Yuri van der Does MD
- Prof. Peter Patka
- Dr. Pleunie Rood