About our research group/lab
The research is focused on understanding molecular immunological mechanisms driving arthritis.
The lab focuses on the role and modulation of lymphocytes in the development of chronic inflammatory autoimmune-mediated diseases with focus on the IL-23/Th17 immune pathway and the role of T cell cytokines, receptors, signaling pathways in the development of chronic inflammatory autoimmune-mediated diseases.
To gain insight into these processes, we use material from cohorts and trials conducted in the department of Rheumatology.
Human Memory Th17 Cell Populations Change Into Anti-inflammatory Cells With Regulatory Capacity Upon Exposure to Active Vitamin D
Dankers W et al Front. Immunol 2019 Jul 17;10:1504
The IL-23–IL-17 axis in inflammatory arthritis
Erik Lubberts. Nature reviews Rheumatology 2015; 11, pages415–429 (2015)
Vitamin D in Autoimmunity: Molecular Mechanisms and Therapeutic Potential
Dankers W et al. Front. Immunol 2017, Jan 20;7:697
How to Prepare Spectral Flow Cytometry Datasets for High Dimensional Data Analysis: A Practical Workflow
Hannah den Braanker, Margot Bongenaar and Erik Lubberts. Front. Immunol.; 19 November 2021
Funding & Grants
Bennie van Heeswijk