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Research project

OA Trial Bank

Status: Ongoing (start: January 2015)

The OA Trial Bank: subgroup meta-analyses with individual patient data in osteoarthritis patients.

What we do

About our project

The OA Trial Bank initiates meta-analyses of effect of treatment on predefined subgroups of osteoarthritis (OA) patients from existing studies, using Individual Patient Data (IPD). Based on the small to moderate effectiveness of the wide range of symptomatic treatments in OA, and the heterogeneity of OA patients, treatment guidelines for OA have stressed the need for research on clinical predictors of response to different treatments.

We aim to identify treatment responsive subgroups of OA patients.

The OA Trial Bank stimulates new initiatives and research questions from researchers and clinicians worldwide. New initiatives will all need to be approved by the steering committee of the OA Trial Bank by means of a (2-page) study protocol. This study protocol should at least include 1.) Background and study aims, 2.) proposed methods including study selection (type of studies, participants, type of interventions), variables, subgroups and outcomes of interest, and statistical analyses. All analyses done under the umbrella of the OA Trial Bank are predefined.

Our research focus

Treatment responsive subgroups for OA patients.

Funds & Grants

Dutch Arthritis Society.


  • Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia
  • Arthritis Research UK Pain Centre, Nottingham, UK
  • Arthritis Research UK Primary Care Centre, Research Institute of Primary Care and Health Sciences, Keele University, Keele, UK
  • School of Healthcare, University of Leeds, UK
  • The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, the University of Sydney, Australia


1: Deveza LA, Bierma-Zeinstra SMA, van Spil WE, Oo WM, Saragiotto BT, Neogi T, van Middelkoop M, Hunter DJ. Efficacy of bisphosphonates in specific knee osteoarthritis subpopulations: protocol for an OA Trial Bank systematic review and individual patient data meta-analysis. BMJ Open. 2018 Dec 19;8(12).

2: Holden MA, Burke DL, Runhaar J, van Der Windt D, Riley RD, Dziedzic K, Legha A, Evans AL, Abbott JH, Baker K, Brown J, Bennell KL, Bossen D, Brosseau L, Chaipinyo K, Christensen R, Cochrane T, de Rooij M, Doherty M, French HP, Hickson S, Hinman RS, Hopman-Rock M, Hurley MV, Ingram C, Knoop J, Krauss I, McCarthy C, Messier SP, Patrick DL, Sahin N, Talbot LA, Taylor R, Teirlinck CH, van Middelkoop M, Walker C, Foster NE; OA Trial Bank. Subgrouping and TargetEd Exercise pRogrammes for knee and hip OsteoArthritis (STEER OA): a systematic review update and individual participant data meta-analysis protocol. BMJ Open. 2017 Dec 22;7(12):e018971.

3: Runhaar J, Rozendaal RM, van Middelkoop M, Bijlsma HJW, Doherty M, Dziedzic KS, Lohmander LS, McAlindon T, Zhang W, Bierma Zeinstra S. Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: a systematic review and individual patient data meta-analysis from the OA trial bank. Ann Rheum Dis. 2017 Nov;76(11):1862-1869.

4: Fu Y, Persson MS, Bhattacharya A, Goh SL, Stocks J, van Middelkoop M, Bierma-Zeinstra SM, Walsh D, Doherty M, Zhang W. Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis. Syst Rev. 2016 Oct 28;5(1):183.

5: Persson MS, Fu Y, Bhattacharya A, Goh SL, van Middelkoop M, Bierma-Zeinstra SM, Walsh D, Doherty M, Zhang W; OA Trial Bank Consortium. Relative efficacy of topical non-steroidal anti-inflammatory drugs and topical capsaicin in osteoarthritis: protocol for an individual patient data meta-analysis. Syst Rev. 2016 Sep 29;5(1):165.

6: van Middelkoop M, Arden NK, Atchia I, Birrell F, Chao J, Rezende MU, Lambert RG, Ravaud P, Bijlsma JW, Doherty M, Dziedzic KS, Lohmander LS, McAlindon TE, Zhang W, Bierma-Zeinstra SM. The OA Trial Bank: meta-analysis of individual patient data from knee and hip osteoarthritis trials show that patients with severe pain exhibit greater benefit from intra-articular glucocorticoids. Osteoarthritis Cartilage. 2016 Jul;24(7):1143-52.

7: van Middelkoop M, Dziedzic KS, Doherty M, Zhang W, Bijlsma JW, McAlindon TE, Lohmander SL, Bierma-Zeinstra SM. Individual patient data meta-analysis of trials investigating the effectiveness of intra-articular glucocorticoid injections in patients with knee or hip osteoarthritis: an OA Trial Bank protocol for a systematic review. Syst Rev. 2013 Jul 5;2:54. doi: 10.1186/2046-4053-2-54.

Our team

Dr. M. van Middelkoop, m.vanmiddelkoop@erasmusmc.nl
Prof. dr. L.S. Lohmander, Stefan.Lohmander@med.lu.se
Prof. dr. M Doherty, Michael.Doherty@nottingham.ac.uk
Prof. dr. KS Dziedzic, k.s.dziedzic@keele.ac.uk
Prof. dr. W Zhang, Weiya.Zhang@nottingham.ac.uk
Prof. dr. T.E. McAlindon, tmcalindon@tuftsmedicalcenter.org
Prof. dr. S.M.A. Bierma-Zeinstra (promotor), s.bierma-zeinstra@erasmusmc.nl

Contact address for the project: m.vanmiddelkoop@erasmusmc.nl.