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Research project  |  Sentinel lymph node procedure in patients with recurrent vulvar squamous cell carcinoma: A multicentre observational study.

V2SLN

We study the feasibility and safety of the sentinel node procedure in recurrent vulvar cancer.

What we do

About our project

Spin-off

The standard groin treatment in recurrent vulvar cancer consists of a unilateral or bilateral inguinal lymph node dissection. In the first episode, however, a sentinel lymph node (SLN) procedure is performed on unifocal tumours < 4cm without suspicious groin lymph nodes at imaging. This procedure is advantageous in that the short and long term sequelae-such as wound healing problems, lymph cyst formation, recurrent erysipelas and lymph oedema-are much less common. In a national retrospective analysis we showed that SLN is feasible in selected patients with recurrent vulvar cancer. We now aim to assess the safety of the procedure. Since little is known on the outcome of a first recurrence of vulvar cancer, we also gather more information on women with a first recurrence not eligible for the SLN procedure. 

Execution of the project 

This is a prospective, multicentre observational study, including all women with a first recurrence of vulvar cancer. Women with a unifocal tumour < 4cm without suspicious groin lymph nodes at imaging will be offered a SLN procedure. Data regarding diagnostic tests, surgery, outcome and treatment will be collected and analyzed. Special attention will be given to treatment decision and treatment regret and to lymph edema.

Impact on patient care 

In the future, when a second SLN procedure is proven feasible and safe, the surgical treatment for recurrent vulvar cancer will have much less impact on the quality of life, similar to the effect of the SLN procedure in women with primary vulvar cancer.

 

V2SLN logo light blue and dark blue with white background

Our research focus

This project complies with our aim to improve our surgical care: to provide the best possible outcome with the least impact on the quality of life of women affected.

Funds & Grants

This study is supported by the involved departments of the participating hospitals. KWF Kankerbestrijding (Dutch Cancer Society) has gifted a grant (KWF 2021-1/13292).

Collaborations

Collaboration within Erasmus MC

  • Departments of Gynaecologic Oncology
  • Department of Biostatistics

Collaboration outside of Erasmus MC

  • Department of Obstetrics and Gynaecology, AMC, Amsterdam
  • Department of Obstetrics and Gynaecology, LUMC, Leiden
  • Department of Obstetrics and Gynaecology, Radboud University, Nijmegen
  • Department of Obstetrics and Gynaecology, UMCG, Groningen

Publications

Repeat sentinel lymph node procedure in patients with recurrent vulvar squamous cell carcinoma is feasible.
van Doorn HC, van Beekhuizen HJ, Gaarenstroom KN, van der Velden J, van der Zee AG, Oonk MH, de Hullu JA. (2016). Gynecologic Oncology. 2016;140(3):415-9.

Our team

  • Lena H. van Doorn, MD PhD, Erasmus MC Cancer Institute, Rotterdam
  • Heleen J van Beekhuizen, MD PhD, Erasmus MC Cancer Institute, Rotterdam
  • Joost M. van Rosmalen, PhD, Erasmus MC, Rotterdam
  • Guus Fons, MD PhD, Department of Obstetrics and Gynaecology, AMC, Amsterdam
  • Katja N. Gaarenstroom, MD PhD, Department of Obstetrics and Gynaecology, LUMC, Leiden
  • Joanne de Hullu, MD PhD, Department of Obstetrics and Gynaecology, Radboud University, Nijmegen
  • Maaike H.M. Oonk, MD PhD, Department of Obstetrics and Gynaecology, UMCG, Groningen

Any questions?

Please contact our office if you have any questions or comments.

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