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Principal Investigator

Dr. R.W.F. (Ron) de Bruin

Associate Professor




I have a long-standing interest in organ injury, inflammation and regeneration following surgical interventions such as organ transplantation and resection of tumours.

We are studying how interventions such as dietary restriction and novel techniques such as machine perfusion may benefit patients using model systems, and translate these findings to human trials. My expertise with both in vitro and in vivo models and clinical research represents a unique opportunity to answer questions with significant impact on both clinical transplantation as well as other stress inducing therapies such as surgery and chemotherapy.

Education and career

2012- present: Associate professor, group leader at the Laboratory for Experimental Transplantation and Intestinal Surgery (LETIS), Department of Surgery, Erasmus University Medical Center Rotterdam

2003 - 2012: Senior Researcher, Laboratory for Experimental Surgery, Department of Surgery, Erasmus MC Rotterdam

1996 - 2002: Research fellow, Laboratory for Experimental Surgery, Department of Surgery, Erasmus MC Rotterdam

1995 - 1996: Post–doc, Monash University, Melbourne, Australia

1993 - 1994: Researcher, Laboratory for Experimental Surgery

1989 - 1993: PhD student, Laboratory for Experimental Surgery, Erasmus University Rotterdam


van Willigenburg H, de Keizer PLJ, de Bruin RWF. Cellular senescence as a therapeutic target to improve renal transplantation outcome. Pharmacol Res. 2018 Apr;130:322-330. DOI: 10.1016/j.phrs.2018.02.015


Jongbloed F, Meijers RWJ, IJzermans JNM, Klaassen RA, Dollé MET, van den Berg S, Betjes MGH, de Bruin RWF, van der Harst E, Litjens NHR.  Effects of bariatric surgery on telomere length and T-cell aging. Int J Obes (Lond). 2019 Nov;43(11):2189-21.  DOI: 10.1038/s41366-019-0351-y


Jongbloed F, Huisman SA, van Steeg H, Pennings JLA, IJzermans JNM, Dollé MET, de Bruin RWF.  The transcriptomic response to irinotecan in colon carcinoma bearing mice preconditioned by fasting. Oncotarget. 2019 Mar 15;10(22):2224-2234. DOI: 10.18632/oncotarget.2677


Jongbloed F, de Bruin RWF, Steeg HV, Beekhof P, Wackers P, Hesselink DA, Hoeijmakers JHJ, Dollé MET, IJzermans JNM. Protein and calorie restriction may improve outcomes in living kidney donors and kidney transplant recipients. Aging (Albany NY). 2020 Jul 11;12(13):12441-12467. DOI: 10.18632/aging.103619


Saat TC, van der Pluijm I, Ridwan Y, van Damme-van den Engel S, van Heijningen PM, Clahsen-van Groningen MC, Verhagen HJM, IJzermans JNM, Essers J, de Bruin RWF. Pre-Operative Fasting Provides Long Term Protection Against Chronic Renal Damage Induced by Ischaemia Reperfusion Injury in Wild Type and Aneurysm Prone Fibulin-4 Mice. Eur J Vasc Endovasc Surg. 2020 Dec;60(6):905-915. DOI: 10.1016/j.ejvs.2020.08.013 

My Groups