M. (Marjolein) Bulk PhD

My research focusses on multi-modal imaging of dementia including postmortem studies and the translation of these findings to patients. As an overarching goal, I would like to characterize dementia and more specifically its subtypes using MRI and other complementary imaging techniques for future diagnostic and mechanistic studies.

• Dementia
• Neurodegeneration
• MRI
• Histology
• Postmortem imaging 

• 2020-present Postdoctoral researcher at the Alzheimercenter Erasmus MC -IRON 4 TAUOPATHIES: Regional iron accumulation as a marker for tau pathology (Alzheimer Nederland)
• 2015-2020 PhD project 'Imaging of iron in neurodegenerative diseases' at the Leiden University Medical Center

Selection of publications

• Postmortem MRI and histology demonstrate differential iron accumulation and cortical myelin organization in early- and late-onset Alzheimer's disease. Bulk M, Abdelmoula WM, Nabuurs RJA, van der Graaf LM, Mulders CWH, Mulder AA, Jost CR, Koster AJ, van Buchem MA, Natté R, Dijkstra J, van der Weerd L. Neurobiol Aging. 2018
• Cerebral Amyloid Angiopathy With Vascular Iron Accumulation and Calcification. Bulk M, Moursel LG, van der Graaf LM, van Veluw SJ, Greenberg SM, van Duinen SG, van Buchem MA, van Rooden S, van der Weerd L. Stroke. 2018
• Normal Aging Brain Collection Amsterdam (NABCA): A comprehensive collection of postmortem high-field imaging, neuropathological and morphometric datasets of non-neurological controls. Jonkman LE, Graaf YG, Bulk M, Kaaij E, Pouwels PJW, Barkhof F, Rozemuller AJM, van der Weerd L, Geurts JJG, van de Berg WDJ. Neuroimage Clin. 2019
• Quantitative MRI and laser ablation-inductively coupled plasma-mass spectrometry imaging of iron in post-mortem frontal cortex of Alzheimer patients. Bulk M, Abdelmoula W, Geut H, Wiarda W, Ronen I, Dijkstra J, van der Weerd L. NeuroImage. 2020

For a full overview please go to pubmed

Supervision of bachelor and master students.

Pilot grant Call Biomedical Research (Alzheimer Nederland).