Bert Mik’s research focuses on the development and use of novel techniques to comprehensively measure tissue oxygenation and cellular oxygen utilization in vivo. Microvascular oxygen tension (μPO2) is measured by means of oxygen-dependent quenching of phosphorescence of injectable oxygen-sensitive dyes. Mitochon-drial oxygen tension (mitoPO2) is measured by delayed fluorescence of protoporphyrin IX. Recent technical advances now allow the simultaneous measurement of μPO2 and mitoPO2 in complex animal models. Next to comprehensive tissue oxygen measurements also a method for assessment of mitochondrial respiration in vivo has been developed. The Laboratory of Experimental Anesthesiology now possesses a unique setup for measuring oxygenation and oxygen consumption at the subcellular level in vivo. Topics of interest are mitochondrial dysfunction in sepsis and cellular adaptation to changes in oxygen homeostasis (oxygen conformance of metabolism).
Next to the preclinical research Bert Mik developed a clinical device for monitoring Cellular Oxygen METabolism (COMET), based on the delayed fluorescence lifetime technique for mitoPO2 measurements. Commercial versions of COMET have become available in 2016 and several clinical studies in and outside the ErasmusMC are currently being performed.
Field(s) of expertise
Education and career
Dec. 2014 Associate professor in Anesthesiology.
2010-2011 Fellow Intensive Care (Erasmus MC).
2006-2010 Residency in Anesthesiology (Erasmus MC).
2003-2005 Internships and degree of MD (AMC).
1994-1998 Study Medicine “Doctoraal Geneeskunde” (AMC).
1992-1994 Applied Physics and Mathematics at the Technical
University of Amsterdam
Prof. dr. C. Ince (promotor), dr. C.J. Zuurbier (co-promotor)
Title: "Measuring Microvascular and Mitochondrial Oxygen Tension
Novel Techniques for Studying Tissue Oxygenation"
2017-present block coordinator "Sensing and Stimulation of Ventilation and Circulation" of the master Technical Medicine
2015-present track coordinator "Sensing and Stimulation" of the master Technical Medicine
2014-present member of “stuurgroep” Eread program
2014-2018 Scientific member of “Instituut voor Dierproeven”
2014 Member of “De Vrije Denkers” betreffende ACE vorming
2011-present Head of Experimental Anesthesiology
2011-present Member of the management team of the
Department of Anesthesiology at Erasmus MC.