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prof. Harm Tiddens
Principal Investigator

H.A.W.M. (Harm) Tiddens, Prof.

Principal investigator

Professor and Principal Investigator of Detection and Monitoring of Lung Abnormalities, chairman Cystic Fibrosis Center

  • Department
  • Paediatric Pulmonology / Radiology & Nuclear Medicine
  • Focus area
  • Clinical Imaging
Contact   External Profile

About

Introduction

What is driving me?

To identify innovative developments that can improve the life and care of patients and to implement these developments into the clinic.

Lead motto

Learn nothing, and the next world is the same as this one, all the same limitations and lead weights to overcome. (Richard Bach, Jonathan Livingston Seagull, 1972).

I started working in structure-function research in 1992 doing my PhD with Professor Paré (Vancouver Canada). Ever since, I have worked on integrating structure-function information for improved diagnosis and monitoring of lung diseases. For this reason, I have systematically worked since 1996 on research for the validation of chest CT as a sensitive outcome measure for CF and other lung diseases. My joint position at the departments of Pediatric Pulmonology and Radiology allows me to bring together the best of function and structure worlds. In addition, in my Erasmus MC Lung Imaging Group (ELIG) there is participation by the Bio Imaging Group Rotterdam (BIGR), allowing a strong research program focused on automated analysis of chest images. Furthermore, in 2014, I founded the Lung Analysis core laboratory, which is executing image analysis for multiple clinical studies. Finally, ELIG has been instrumental in standardizing chest CT acquisition in over 40 CF centers worldwide to allow the use of chest CT as an outcome measure in clinical studies. In addition to our CT-related research, we have a development program focused on the use of chest MRI for combined assessment of lung function and structure.

Field(s) of expertise

Research for the validation of chest CT and MRI as a sensitive outcome measure for CF and other lung diseases such as BPD, Asthma, PCD, CLA, etc.

Education and career

1985: University of Amsterdam: Medical training MD.

1991: Wilhelmina Children’s Hospital Utrecht + St. Elisabeth Hospital Tilburg Specialist training in pediatrics.

1994: Erasmus MC Sophia Children’s Hospital, Rotterdam Training in Pediatric Respiratory Medicine.

1998: PhD Thesis Erasmus MC, Rotterdam. Pediatric Respiratory Medicine.

2009: Professor of Pediatric Pulmonology, Erasmus MC Rotterdam Pediatric Respiratory Medicine.

Publications

  1. Scholte BJ, Horati H, Veltman M, Vreeken RJ, Garratt LW, Tiddens HAWM, Janssens HM, Stick SM; Australian Respiratory Early  Surveillance Team for Cystic Fibrosis (AREST CF). Oxidative stress and abnormal bioactive lipids in early cystic fibrosis lung disease. J Cyst Fibros 2019; Apr 25. Pii: S1569-1993(19)30071-2. Doi: 10.1016/j/jcf.2019.04.011 [Epub ahead of print].
  2. Rosenow T, Mok LC, Turkovic L, Berry LJ, Sly PD, Ranganathan S, Tiddens HAWM, Stick SM. The cumulative effect of inflammation and infection on structural lung disease in early CF. The cumulative effect of inflammation and infection on structural lung disease in early CF. Eur Respir J 2019; Apr. 25. Pii: 1801771. Doi: 10.1183/13993003.01771-2018 [Epub ahead of print].
  3. Elders BBLJ, Hermelijn SM, Tiddens HAWM, Pullens B, Wielopolski PA, Ciet P. Magnetic resonance imaging of the larynx in the pepediatric population: a systematic review. Pediatr Pulmonol 2019; 54: 478-486.
  4. Nguyen AH, Perez-Rovira A, Wielopolski PA, Hernandez Tamames JA, Duijts L, de Bruijne M, Aliverti A, Pennati F, Ivanovska T, Tiddens HAWM, Ciet P. Technical challenges of quantitative chest MRI data analysis in a large cohort pediatric study. Eur Radiol. 2019; 29: 2770-2782.
  5. Winter-de Groot KM de, Janssens HM, van Uum RT, Dekkers JF, Berkers G, Vonk A, Kruisselbrink E, Oppelaar H, Vries R, Clevers H, Houwen RHJ, Escher JC, Elias SG, de Jonge HR, de Rijke YB, Tiddens HAWM, van der Ent EK, Beekman JM. Stratifying infants with cystic fibrosis for disease severity using intestinal organoid swelling as a biomarker of CFTR function. Eur Respir J 2018; 52: 1702529.
  6. Harlaar L, Ciet P, van der Ploeg AT, Brusse E, van der Beek NAME, Wielopolski PA, de Bruijne M, Tiddens HAWM, van Doorn PA. Imaging of respiratory muscles in neuromuscular disease: a review. Neuromuscul Disord 2018; 28: 246-256.
  7. Romei C, Turturici L, Tavanti L, Miedema J, Fiorini S, Marletta M, Wielopolski P, Tiddens H, Falaschi F, Ciet P. The use of chest magnetic resonance imaging in interstitital lung disease: a systematic review. Eur Respir Rev 2018; 27: 180062 [httpss://doi.org/10.1183/16000617.0062-2018]
  8. Chandler JD, Margaroli C, Horati H, Kilgore MB, Veltman M, Liu HK, Taurone AJ, Peng L, Guglani L, Uppal K, Go Y-M, Tiddens HAWM, Scholte BJ, Tirouvanziam R, Jones DP, Janssens HJ. Myeloperoxidase oxidation of methionine associates with early cystic fibrosis lung disease. Eur Respir J 2018; 52: 1801118.
  9. Kuo W, Ciet P, Andrinopoulou E-R, Chen Y, Pullens B, Garcia-Pena P, Fleck RJ, Paoletti M, McCartin M, Vermeulen F, Morana G, Lee EY, Tiddens HAWM for the Normal Chest CT Study Group. Reference values for central airway dimensions on CT images of children and adolescents. Am J Roentgenol 2018; 210: 423-430.
  10. Tiddens HAWM, Kuo W, van Straten M, Ciet P. Paediatric lung imaging: the times they are a-changin’. Eur Respir Rev 2018; 27: 170097.
  11. Bos AC, Mouton JW, van Westreenen M, Andrinopoulou E-R, Janssens HM, Tiddens HAWM. Patient-specific modelling of regional tobramycin concentration levels in airways of patients with cystic fibrosis: can we dose once daily? J Antimicrob Chemother 2017; 72: 3435-3442.
  12. Kuo W, de Bruijne M, Petersen J, Nasserinejad K, Ozturk H, Chen Y, Perez-Rovira A, Tiddens HAWM. Diagnosis of bronchiectasis and airway wall thickening in children with cystic fibrosis: Objective airway-artery quantification. Eur Radiol 2017; 27: 4680-4689.
  13. Kuo W, Soffers T, Andrinopoulou ER, Rosenow T, Ranganathan S, Turkovic L, Stick SM, Tiddens HAWM; AREST CF. Quantitative assessment of airway dimensions in young children with cystic fibrosis lung disease disease using chest computed tomography. Pediatr Pulmonol 2017; 52: 1414-1423.
  14. Grasemann H, Ciet P, Amin R, McDonald N, Klingel M, Tiddens HAWM, Ratjen F, Grosse-Wortmann L. Changes in magnetic resonance imaging scores and ventilation inhomogeneity in children with cystic fibrosis pulmonary exacerbations. Eur Respir J 2017; 50: 170024 [https://doi.org/10.1183/13993003.00244-2017].
  15. Melki I, Rose Y, Uggenti C, Van Eyck L, Frémond M-L, Kitabayashi N, Rice GI, Jenkinson EM, Boulai A, Jeremiah N, Gattorno M, Volpi S, Sacco Ok, Terheggen-Lagro SWJ, Tiddens HAWM, Meyts I, Morren M-A, De Haes P, Wouters C, Legius E, Corveleyn A, Rieux-Laucat F, Bodemer C, Callebaut I, Rodero MP, Crow YJ. Disease-associated mutations identify a novel region in human STING necessary for the control of type I interferon signaling. J Allergy Clin Immunol 2017; 140: 543-552.
  16. Caudri D, Zitter D, Bronsveld I, Tiddens H. Is sweat chloride predictive of severity of cystic fibrosis lung disease assessed by chest computed tomography? Pediatr Pulmonol 2017; 52: 1135-1141.
  17. Ciet P, Bertolo S, Ros M, Andrinopoulou ER, Tavano V, Lucca F, Feiweier T, Krestin GP, Tiddens HAWM, Morana G. Detection and monitoring of lung inflammation in cystic fibrosis during respiratory tract exacerbation using diffusion-weighted magnetic resonance imaging. Eur Respir J 2017; 50: 1601437 [https://doi.org/10.1183/13993003.01437-2016].
  18. Mastrigt E van, Kakar E, Ciet P, den Dekker HT, Joosten KF, Kalkman P, Swarte R, Kroon AA, Tiddens HAWM, de Jongste JC, Reiss I, Duijts L, Pijnenburg MW. Structural and functional ventilatory impairment in infants with severe bronchopulmonary dysplasia. Pediatr Pulmonol 2017; 52: 1029-1037.
  19. De Boeck K, Haarman E, Hull J, Lands LC, Moeller A, Munck A, Riethmüller J, Tiddens H, Volpi S, Leadbetter J, Charlton B, Malfroot A, for the DPM-CF-204 Study Group. Inhaled dry powder mannitol in children with cystic fibrosis: A randomised efficacy and safety trial. J Cyst Fibros 2017; 16: 380-387.
  20. Schoser B, Fond E, Geberhiwot T, Hughes D, Kissel JT, Madathil SC, Orlikowski D, Polkey MI, Roberts M, Tiddens HAWM, Young P. Maximum inspiratory pressure as a clinically meaningful trial endpoint for neuromuscular diseases: a comprehensive review of the literature. Orphanet J Rare Dis 2017; 12: 52 (12 pp).
  21. Prevaes SMPJ, de Steenhuijsen Piters WAA, de Winter-de Groot KM, Janssens HM, Tramper-Stranders GA, Chu MLJN, Tiddens HA, van Westreenen M, van der Ent CK, Sanders EAAM, Bogaert D. Corcordance between upper and lower airway microbiota in infants with cystic fibrosis. Eur Respir J 2017; 49: 1602235 [https://doi.org/10.1183/13993003.02235-2016]
  22. Szczesniak R, Turkovic L, Andrinopoulou ER, Tiddens HAWM. Chest imaging in cystic fibrosis studies: What counts, and can be counted? J Cyst Fibros 2017; 16: 175-185.
  23. Salamon E, Lever S, Kuo W, Ciet P, Tiddens HA. Spirometer guided chest imaging in children: It is worth the effort! Pediatr Pulmonol 2017; 52: 48-56.
  24. Bos AC, Passé KM, Mouton JW, Janssens HM, Tiddens HAWM. The fate of inhaled antibiotics after deposition in cystic fibrosis: How to get drug to the bug? J Cyst Fibros 2017; 16: 13-23.
  25. Kuo W, Andrinopoulou ER, Perez-Rovira A, Ozturk H, de Bruijne M, Tiddens HA.Objective airway artery dimensions compared to CT scoring methods assessing structural cystic fibrosis lung disease. J Cyst Fibros 2017; 16: 116-123.
  26. Perez-Rovira A, Kuo W, Petersen J, Tiddens HA, de Bruijne M.Automatic airway-artery analysis on lung CT to quantify airway wall thickening and bronchiectasis. Med Phys 2016; 43: 5736.
  27. van Mastrigt E, Logie K, Ciet P, Reiss IK, Duijts L, Pijnenburg MW, Tiddens HA.Lung CT imaging in patients with bronchopulmonary dysplasia: A systematic review. Pediatr Pulmonol 2016; 51: 975-86.
  28. Kilcoyne A, Lavelle LP, McCarthy CJ, McEvoy SH, Fleming H, Gallagher A, Loeve M, Tiddens H, McKone E, Gallagher CC, Dodd JD. Chest CT abnormalities and quality of life: relationship in adult cystic fibrosis. Ann Transl Med 2016; 4: 87.
  29. Ciet P, Serra G, Andrinopoulou ER, Bertolo S, Ros M, Catalano C, Colagrande S, Tiddens HA, Morana G. Diffusion weighted imaging in cystic fibrosis disease: beyond morphological imaging. Eur Radiol 2016; 26: 3830-3839.
  30. Bos AC, Tiddens HA, Tong Minh K, Heeres I, Overweel-Uijterlinde JL, Kok AE, Andrinopoulou ER, Janssens HM. Daily Observations of Nebuliser Use and Technique (DONUT) in children with cystic fibrosis. J Cyst Fibros 2016; 15: 645-651.
  31. Velzen AJ van, Bos AC, Touw DJ, Tiddens HA, Heijerman HG, Janssens HM. Pharmacokinetics and tolerability of once daily double dose tobramycin inhalation in cystic fibrosis using controlled and conventional nebulization. J Aerosol Med Pulm Drug Deliv 2016; 29: 273-280.
  32. Tepper LA, Caudri D, Perez Rovira A, Tiddens HAWM, de Bruijne M. The development of bronchiectasis on chest computed tomography in children with cystic fibrosis: can pre-stages be identified? Eur Radiol 2016; 26: 4563-4569.
  33. Bajard A, Chabaud S, Cornu C, Castellan A-C, Malik S, Kurbatova P, Volpert V, Eymard N, Kassai B, Nony P, and the CRESim & Epi-CRESim study groups (a.o. Tiddens HAWM). An in silico approach helped to identify the best experimental design, population, and outcome for future randomized clinical trials. J Clin Epidemiol 2016; 69: 125-135.
  34. Kurbatova P, Wendling F, Kaminska A, Rosati A, Nabbout R, Guerrini R, Dulac O, Pons G, Cornu C, Nony P, the CRESIM/EpiCRESIM Study Group (a.o. Tiddens HAWM), Chiron C, Benquet P. Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome. Exp Neurol 2016; 283: 57-72.
  35. Kuo W, Kemner-van de Corput MPC, Perez-Rovira A, de Bruijne M, Fajac I, Tiddens HAWM, van Straten M on behalf of the ECFS-CTN/SCIFI CF study group. Multicenter chest computed tomography standardization in children and adolescents with CF: the way forward. Eur Respir J 2016; 47: 1706-1717.
  36. Tepper LA, Ciet P, Caudri D, Quittner AL, Utens EM, Tiddens HA. Validating chest MRI to detect and monitor cystic fibrosis lung disease in a pediatric cohort. Pediatr Pulmonol 2016; 51: 34-41.
  37. Mogalle K, Perez-Rovira A, Ciet P, Wens SCA, van Doorn PA, Tiddens HAWM, van der Ploeg AT, de Bruijne M. Quantification of diaphragm mechanics in Pompe Disease using dynamic 3D MRI. PLOS ONE 2016; 11(7): e0158912 (24 pp.).
  38. Spoel  M, Marshall H, Ijsselstijn H, Parra-Robles J, van der Wiel E, Swift AJ, Rajaram S, Tibboel D, Tiddens HAWM, Wild JM. Pulmonary ventilation and micro-structural findings in congenital diaphragmatic hernia. Pediatr Pulmonol 2016; 51: 517-524.
  39. Prevaes SM, de Winter-de Groot KM, Janssens HM, de Steenhuijsen Piters WA, Tramper-Stranders GA, Wyllie AL, Hasrat R, Tiddens HA, van Westreenen M, van der Ent CK, Sanders EA, Bogaert D. Development of the nasopharyngeal microbiotia in infants with cystic fibrosis. Am J Respir Crit Care Med 2016; 193: 504-515.
  40. Boon M, Verleden SE, Bosch B. Lammertyn EJ, McDonough JE, Mai C, Verschakelen J, Kemner-van de Corput M, Tiddens HA, Proesmans M, Vermeulen FL, Verbeken EK, Cooper J, van Raemdonck DE, Decramer M, Verleden GM, Hogg JC, Dupont LJ, Vanaudenaerde BM, De Boeck. Morphometric analysis of explant lungs in cystic fibrosis. Am J Respir Crit Care Med 2016; 193: 516-526.
  41. Ciet P, Serra G, Bertolo S, Spronk S, Ros M, Fraioli F, Quattrucci S, Assael MB, Catalano C, Pomerri F, Tiddens HAWM, Morana G. Assessment of CF lung disease using motion corrected PROPELLER MRI: a comparison with CT. Eur Radiol 2016; 26: 780-787.
  42. Rosenow T, Oudraad MC, Murray CP, Turkovic L, Kuo W, de Bruijne M, Ranganathan SC, Tiddens HA, Stick SM: AREST CF. PRAGMA-CF: a Quantitative Structural Lung Disease CT Outcome in Young Children with Cystic Fibrosis (letter-to-editor, author’s reply). Am J Respir Crit Care Med 2015; 192; 1397-1399.
  43. Ploeg CPB van der, van den Akker-van Marle ME, Vernooij-van Langen AMM, Elvers LH, Gille JJP, Verkerk PH, Dankert-Roelse JE, on behalf of the CHOPIN study group. Cost-effectiveness of newborn screening for cystic fibrosis detemined with real-life data. J Cystic Fibr 2015; 14: 194-202.
  44. Tiddens HAWM, Stick SM, Wild JM, Ciet P, Parker GJM, Koch A, Vogel-Claussen J. Respiratory tract exacerbations revisited: ventilation, inflammation, perfusion and structure (VIPS) monitoring to redefine treatment. Pediatr Pulmonol 2015; 50: S57-S65.
  45. Tiddens HA, Puderbach M, Venegas JG, Ratjen F, Donaldson SH, Davis SD, Rowe SM, Sagel SD, Higgins M, Waltz DA. Novel outcome measures for clinical trials in cystic fibrosis. Pediatr Pulmonol 2015; 50: S57-S65.
  46. Ciet P, Tiddens HA, Wielopolski PA, Wild JM, Lee EY, Morana G, Lequin MH. Magnetic resonance imaging in children: common problems and possible solutions for lung and airways imaging. Pediatr Radiol 2015; 45: 1901-1915.
  47. Loeve M, Rosenow T, Gorbunova V, Hop WC, Tiddens HA, de Bruijne M. Reversibility of trapped air on chest computed tomography in cystic fibrosis patients. Eur J Radiol 2015; 84: 1184-1190.
  48. Vernooij-van Langen A, Dompeling E, Yntema J-B, Arets B, Tiddens H, Loeber G, Dankert-Roelse J. Clinical evaluation of the Nanoduct sweat test system in the diagnosis of cystic fibrosis after newborn screening. Eur J Pediatr 2015; 174: 1025-1034.
  49. Rosenow T, Oudraad MC, Murray CP, Turkovic L, Kuo W, de Bruijne M, Ranganathan SC, Tiddens HA, Stick SM; AREST CF. PRAGMA-CF: a quantitative structural lung disease CT outcome in young children with cystic fibrosis. Am J Respir Crit Care Med 2015; 191: 1158-1165. 
  50. Wens SCA, Ciet P, Perez-Rovira A, Logie K, Salamon E, Wielopolski P, de Bruijne M, Kruijshaar ME, Tiddens HAWM, van Doorn PA, van der Ploeg AT. Lung MRI and impairment of diaphragmatic function in Pompe disease. BMC Pulmonary Med 2015; 15: 54 (7 pp.).
  51. Kurbatova P, Bessonov N, Volpert V, Tiddens HA, Cornu C, Nony P, Caudri D: CRESim Working Group. Model of mucociliary clearance in cystic fibrosis lungs.J Theor Biol 2015; 372: 81-88.
  52. Tiddens HAWM, De Boeck K, Clancy JP, Fayon M, Arets HGM, Bresnik M, Derchak A, Lewis SA, Oermann CM for the ALPINE study investigators. Open label study of inhaled aztreonam for Pseudomonas eradication in children with cystic fibrosis: The ALPINE study. J Cystic Fibr 2015; 14: 111-119.
  53. Bos AC, van Holsbeke C, de Backer JW, van Westreenen M, Janssens HM, Vos WG, Tiddens HAWM. Patient-specific modeling of regional antibiotic concentration levels in airways of patients with cystic fibrosis: are we dosing high enough? Plos One 2015; 10(3): e0118454 (20 p.).
  54. Bakker M, Borsboom G, Tiddens H. Small Airway Involvement in Cystic Fibrosis Lung Disease: Routine Spirometry as an Early and Sensitive Marker. The authors reply. Pediatr Pulmonol 2014; 49: 1256-1257.
  55. Tepper LA, Caudri D, Utens EM, van der Wiel EC, Quittner AL, Tiddens HA. Tracking CF disease progression with CT and respiratory symptoms in a cohort of children aged 6-19 years. Pediatr Pulmonol 2014; 49: 1182-1189.
  56. Tiddens HA, Rosenow T. What did we learn from two decades of chest computed tomography in cystic fibrosis? Pediatr Radiol 2014; 44: 1490-1495.
  57. Tiddens HAWM, Bos AC, Mouton JW, Devadason S, Janssens HM. Inhaled antibiotics: dry or wet? Eur Respir J 2014; 44: 1308-1318.
  58. Kuo W, Ciet P, Tiddens H, Zhang W, Guillerman RP, van Straten M. Cumulative radiation exposure to abdominal organs in patients with cystic fibrosis should not be forgotten (letter-to-the-editor: authors' reply). Am J Respir Crit Care Med 2014; 190: 962.
  59. Moodie M, Lal A, Vidmar S, Armstrong DS, Byrnes CA, Carlin JB, Cheney J, Cooper PJ, Grimwood K, Robertson CF, Tiddens HA. Costs of bronchoalveolar lavage-directed therapy in the first 5 years of life for children with cystic fibrosis. J Pediatr 2014; 165: 564-569.
  60. Bortoluzzi CF, Volpi S, D’Orazio C, Tiddens HA, Loeve M, Tridello G, Assael BM. Bronchiectases at early chest computed tomography in children with cystic fibrosis are associated with increased risk of subsequent pulmonary exacerbations and chronic pseudomonas infection. J Cyst Fibros 2014; 13: 564-517.
  61. Kuo W, Ciet P, Tiddens HAWM, Zhang W, Guillerman RP, van Straten M. Monitoring cystic fibrosis lung disease by computed tomography: radiation risk in perspective. Am J Respir Crit Care Med 2014; 189: 1328-1336.
  62. Ciet P, Wielopolski P, Manniesing R, Lever S, de Bruijne M, Morane G, Muzzio PC, Lequin MH, Tiddens HA. Spirometer controlled cine-magnetic resonance imaging to diagnose tracheobronchomalacia in pediatric patients. Eur Respir J 2014; 43: 115-24.
  63. Bakker EM, Volpi S, Salonini E, Müllinger B, Kroneberg P, Bakker M, Hop WC, Assael BM, Tiddens HA. Small airway deposition of dornase alfa during exacerbations in cystic fibrosis; a randomized controlled clinical trial. Pediatr Pulmonol 2014; 49: 154-161.
  64. Tiddens HA, Stick SM, Davis S. Multi-modality monitoring of cystic fibrosis lung disease: the role of chestcomputed tomography. Paediatr Respir Rev 2014; 15: 92-97.]
  65. Kent BD, Lane SJ, van Beek EJ, Dodd JD, Costello RW, Tiddens HA. Asthma and cystic fibrosis: a tangled web. Pediatr Pulmonol 2014; 49 205-213.
  66. De Boeck K, Tiddens H, Elborn S, Fajac I; European Cystic Fibrosis Society (ECFS) and the ECFS Clinical Trial Network. A new Clinical Trials Directive to boost academic trials? Lancet Respir Med 2013; 1: 99-101.
  67. Bakker EM, van der Wiel-Kooij EC, Müllinger B, Kroneberg P, Hop WCJ, Tiddens HAWM. Small-airways deposition of dornase alfa in children with asthma and persistent airway obstruction (letter to the editor). J Allergy Clin Immunol 2013; 132: 482-485.e10.
  68. Tepper LA, Utens E, Caudri D, Bos A, Gonzalez-Graniel K, Duivenvoorden H, van der Wiel E, Quittner A, Tiddens HA. Impact of bronchiectasis and trapped air on quality of life and exacerbations in CF. Eur Respir J. 2013; 42: 371-379. 
  69. Stick S, Tiddens H, Aurora P, Gustafsson P, Ranganathan S, Robinson P, Rosenfeld M, Sly P, Ratjen F. Early intervention studies in infants and preschool children with cystic fibrosis: are we ready? Eur Respir J 2013; 42: 527-538.
  70. Loeve M, Krestin GP, Rosenfeld M, de Bruijne M, Stick SM, Tiddens HA. Chest computed tomography; a validated surrogate endpoint of cystic fibrosis lung disease? Eur Respir J 2013; 42: 844-857.
  71. Bakker EM, Borsboom GJ, van der Wiel-Kooij EC, Caudri D, Rosenfeld M, Tiddens HA. Small airway involvement in cystic fibrosis lung disease: routine Spirometry as an early and sensitive marker. Pediatr Pulmonol 2013; 48: 1081-1088.
  72. Mott LS, Graniel KG, Park J, de Klerk NH, Sly PD, Murray CP, Tiddens HA, Stick SM.  Assessment of early bronchiectasis in young children with cystic fibrosis is dependent on lung volome. Chest 2013; 144: 1193-1198.
  73. Byrnes CA, Vidmar S, Cheney JL, Carlin JB, Armstrong DS, Cooper PJ, Grimwood K, Moodie M, Robertson CF, Rosenfeld M, Tiddens HA, Wainwright CE; for the ACFBAL Study Investigators. Prospective evaluation of respiratory exacerbations in children with cystic fibrosis from newborn screening to 5 years of age. Thorax. 2013; 68: 643-651.
  74. Cornu C, Kassai B, Fisch R, Chiron C, Alberti C, Guerrini R, Rosati A, Pons G, Tiddens H, Chabaud S, Caudri D, Ballot C, Kurbatova P, Castellan A-C, Bajard A, Nony P, and the CRESim & Epi-CRESim Project Groups. Experimental designs for small randomised clinical trials: an algorithm for choice. Orphanet Journal of Rare Diseases 2013; 8: 48 (12 p).
  75. Loeve M, de Bruijne M, Hartmann ICJ, van Straten M, Hop WCJ, Tiddens HAWM. Three-section expiratory CT: insufficient for trapped air assessment in patients with cystic fibrosis? Radiology 2012; 262: 969-976.
  76. Tiddens HAWM. Editorial for effect of dornase alfa on inflammation and lung function: potential role in the early treatment of cystic fibrosis. Editorial. J Cystic Fibrosis 2012; 11: 77.
  77. Bakker EM, van der Meijden JC, Nieuwhof EM, Hop WCJ, Tiddens HAWM. Determining presence of lung disease in young children with cystic fibrosis: Lung clearance index, oxygen saturation and cough frequency. J Cystic Fibrosis 2012; 11: 223-230.
  78. Gorbunova V, Sporring J, Lo P, Loeve M, Tiddens HA, Nielsen M, Dirksen A, de Bruijne M. Mass preserving image registration for lung CT. Med Image Anal 2012; 16: 786-795.
  79. Sawicki GS, Tiddens H. Managing treatment complexity in cystic fibrosis: Challenges and opportunities. Pediatr Pulmonol. 2012; 47: 523-533.
  80. Loeve M, Hop WC, de Bruijne M, van Hal PT, Robinson P, Aitken ML, Dodd JD, Tiddens HA; on behalf of the Computed Tomography Cystic Fibrosis Survival Study Group. Chest Computed Tomography Scores are Predictive of Survival in CF Patients Awaiting Lung Transplantation. Am J Respir Crit Care Med. 2012; 185: 1096-1103.
  81. van der Giessen L, Bakker M, Joosten K, Hop W, Tiddens H. Nocturnal oxygen saturation in children with stable cystic fibrosis. Pediatr Pulmonol. 2012; 47: 1123-1130.
  82. Amin R, Charron M, Grinblat L, Shammas A, Grasemann H, Graniel K, Ciet P, Tiddens H, Ratjen F. Cystic Fibrosis: Detecting Changes in Airway Inflammation with FDG PET/CT. Radiology 2012; 264: 868-875.
  83. Littlewood KJ, Higashi K. Jansen JP, Capkun-Niggli G, Balp M-M, Doering G, Tiddens HAWM, Angyalosi G. A network meta-analysis of the eficacy of inhaled antibiotics for chronic Pseudomonas infections in cystic fibrosis. J Cyst Fibros 2012; 11: 419-426.
  84. McEvoy S, Lavelle L, Kilcoyne A, McCarthy C, de Jong PA, Loeve M, Tiddens HAWM, McKone E, Gallagher CG, Dodd JD. High-resolution CT of nontuberculous mycobacterium infection in adult CF patients: diagnostic accuracy. Eur Radiol 2012; 22: 2736-2742.
  85. Spoel M, van de Ven KP, Tiddens HAWM, Hop WCJ, Wijnen RMH, Tibboel D, IJsselstijn H for the Congenital Lung Malformations Study Group. Neonatology 2013; 103: 60-66.
  86. De Wit MCY, Tiddens HAWM, de Coo IFM, Mancini GMS. Lung disease in FLNA mutation: Confirmatory report. Eur J Med Genet 2011; 54: 299-300.
  87. Loeve M, Gerbrands K, Hop WC, Rosenfeld M, Hartmann IC, Tiddens HA. Bronchiectasis and pulmonary exacerbations in children and young adults with cystic fibrosis. Chest 2011; 140: 178-185.
  88. Wainwright CE, Vidmar S, Armstrong DS, Byrnes CA, Carlin JB, Cheney J, Cooper PJ, Grimwood K, Moodie M, Robertson CF, Tiddens HA, for the ACFBAL study investigators. Effect of bronchoalveolar lavage-directed therapy on Pseudomonas aeruginosa infection and structural lung injury in children with cystic fibrosis. JAMA 2011; 306; 163-171.
  89. De Boeck K, Bulteel V, Tiddens H, Wagner T, Fajac I, Conway S, Dufour F, Smyth AR, Lee T, Sermet I, Kassai B, Elborn S on behalf of all ECFS-CTN network partners. Guideline on the design and conduct of cystic fibrosis clinical trials: The European Cystic Fibrosis Society - Clinical Trials Network (ECFS-CTN). J Cyst Fibrosis 2011; 10 (Suppl.2): S67-S74.
  90. Bodewes R, Fraaij PLA, Geelhoed-Mieras MM, van Baalen CA, Tiddens HAWM, van Rossum AMC, van der Klis FR, Fouchier RAM, Osterhaus ADME, Rimmelzwaan GF. Annual vaccination against influenza virus hampers development of virus-specific CD8+ T cell immunity in children. J Virol 2011; 85: 11995-12000.
  91. Bakker EM, Volpi S, Salonini E, van der Wiel-Kooij EC, Sintnicolas CJJCM, Hop WCJ, Assael Bm, Merkus PJFM, Tiddens HAWM. Improved treatment response to dornase alfa in cystic fibrosis patients using controlled inhalation. Eur Respir J 2011; 38: 1328-1335.
  92. Tiddens HAWM, Donaldson SH, Rosenfeld M, Paré PD. Cystic fibrosis lung disease starts in the small airways: can we treat it more effectively? Pediatr Pulmonol 2010; 45: 107-117.
  93. Robroeks CMHHT, Roozeboom MH, de Jong PA, Tiddens HAWM, Jöbsis Q, Hendriks HJ, Yntema J-BL, Brackel HL, van Gent R, Robben S, Dompeling E. Structural lung changes, lung function, and non-invasive inflammatory markers in cystic fibrosis. Pediatr Allergy Immunol 2010; 21: 493-500.
  94. Van Westreenen M, Tiddens HAWM. New antimicrobial strategies in cystic fibrosis. Pediatr Drugs 2010; 12: 343-352.
  95. Eichinger M, Heussel C-P, Kauczor H-U, Tiddens HAWM, Puderbach M. Computed tomography and magnetic resonance imaging in cystic fibrosis lung disease. J Magn Reson Imaging 2010; 32: 1370-1378.
  96. De Boeck K, Bulteel V, Tiddens H, Wagner T, Fajac I, Conway S, Dufour F, Smyth A, Lee T, Sermet I, Kassai-Koupai B, Elborn S on behalf of all ECFSCTN network partners. Guideline on the design and conduct of cystic fibrosis clinical trials: The European Cystic Fibrosis Society - Clinical Trial Network (ECFS-CTN). J Cyst Fibros 2010; 9: S58-S65.
  97. Failo R, Wielopolski PA, Tiddens HAWM, Hop WCJ, Pozzi Mucelli R, Lequin MH. Long morphology assessment using MRI: a robust ultra-short TR/TE 2D steady state free precession sequence used in cystic fibrosis patients. Magn Reson Imaging 2009; 61: 299-306.
  98. Tiddens HAWM. Quality improvement in your CF centre: taking care of care. J Cystic Fibrosis 2009; 8: S2-5.
  99. Tiddens HAWM. Striving for excellence: optimising CF patient care today. Introduction. J Cystic Fibrosis 2009; 8: S1.
  100. van der Giessen L, Loeve M, de Jongste J, Hop W, Tiddens H. Nocturnal cough in children with stable cystic fibrosis. Pediatr Pulmonol 2009; 44: 859-865.
  101. Mc Dermott S, Barry SC, Judge EE, Collins S, de Jong PA, Tiddens HAWM, McKone EF, Gallagher CC, Dodd JD. Tracheomalacia in adults with cystic fibrosis: determination of prevalence and severity with dynamic cine CT. Radiology 2009; 252: 577-586.
  102. Dorfman R, Li W, Sun L, Lin F, Wang Y, Sandford A, Paré PD, McKay K, Kayserova H, Piskackova T, Macek M, Czerska K, Sands D, Tiddens H, Margarit S, Repetto G, Sontag MK, Accurso FJ, Blackman S, Cutting GR, Tsui LC, Corey M, Durie P, Zielenski J, Strug LJ. Modifier gene study of meconium ileus in cystic fibrosis: statistical considerations and gene mapping results. Hum Genet 2009; 126: 763-778.
  103. Loeve M, Lequin MH, de Bruijne M, Hartmann IJC, Gerbrands K, van Straten M, Hop WCJ, Tiddens HAWM. Cystic fibrosis: Are volumetric ultra-low-dose expiratory CT scans sufficient for monitoring related lung disease? Radiology 2009: 253: 223-229.
  104. Loeve M, van Hal PThW, Robinson P, de Jong PA, Lequin MH, Hop WC, Williams TJ, Nossent GD, Tiddens HA. The spectrum of structural abnormalities on CT scans from patients with CF with severe advanced lung disease. Thorax 2009; 64: 876-882.
  105. Hughes D, Tiddens H, Wild JM. Lung imaging in cystic fibrosis. Imaging Decisions 2009; 1: 28-37.
  106. Gustafsson PM, De Jong PA, Tiddens HA, Lindblad A. Multiple-breath inert gas washout and spirometry versus structural lung disease in cystic fibrosis. Thorax 2008; 63:129-134.
  107. Santamaria F, Montella S, Tiddens HAWM, Guidi G, Casotti V, Maglione M, de Jong PA. Structural and functional lung disease in primary ciliary dyskinesia. Chest 2008; 134: 351-357.
  108. de Jong PA, Tiddens HA, Lequin MH, Robinson TE, Brody AS. Estimation of the radiation dose from CT in cystic fibrosis (letter-to-the-editor). Chest 2008; 133: 1289-1291.
  109. Boogaard R, de Jongste JC, Lequin MH, Devos AS, Tiddens HAWM, Merkus PJFM. Yield from flexible bronchoscopy in pediatric cystic fibrosis patients. J Bronchol 2008; 15: 240-246.
  110. Tiddens HAWM, Hofhuis W, Casotti V, Hop WC, Hulsmann AR, de Jongste JC. Airway dimensions in bronchopulmonary dysplasia: implications for airflow obstruction. Pediatr Pulmonol 2008; 43: 1206-1213.
  111. Janssens HM, Ruijgrok EJ, Tiddens HAWM. Aerosol therapy in hospital: paediatric principles. EJHP Practice 2008; 14: 65-67.
  112. Giessen LJ van der, de Jongste JC, Gosselink R, Hop WCJ, Tiddens HAWM. RhDNase before airway clearance therapy improves airway patency in children with CF. Pediatr Pulmonol 2007; 42: 624-630.
  113. Tiddens HAWM, Rosenfeld M, Brody AS, Guest editors. Imaging endpoints for cystic fibrosis clinical trials. Proc Am Thorac Soc 2007; 4: 297-430. 
  114. Tiddens HAWM, Brody AS. Monitoring cystic fibrosis lung disease in clinical trials: Is it time for a change? Proc Am Thorac Soc 2007; 4: 297-298.
  115. de Jong PA, Tiddens HAWM. Cystic fibrosis-specific computed tomography scoring. Proc Am Thorac Soc 2007; 4: 338-342.
  116. Tiddens HAWM, de Jong PA. Imaging and clinical trials in cystic fibrosis. Proc Am Thorac Soc 2007; 4: 343-346.
  117. Giessen LJ van der, Gosselink R, Hop WCJ, Tiddens HAWM. Recombinant human DNase nebulisation in children with cystic fibrosis: before bedtime or after waking up? Eur Respir J 2007; 30: 763-768.
  118. Merkus P, Janssens H, Pijnenburg M, Tiddens H, de Jongste JC. Dexamethasone to prevent postbronchoscopy fever in children (letter-to-the-editor). Chest 2007; 132: 1413-1414.
  119. Bakker EM, Tiddens HAWM. Pharmacology, clinical efficacy and safety of recombinant human DNase in cystic fibrosis. Expert Rev Resp Med 2007; 1: 317-329.
  120. de Jong PA, Long FR, Wong JC, Merkus PJ, Tiddens HA, Hogg JC, Coxson HO. Computed tomographic estimation of lung dimensions throughout the growth period. Eur Respir J 2006; 27: 261-267.
  121. Tiddens HAWM. How to determine the condition of your lungs / Comment évaluer l'état des poumons. SVB Adult Cystic Fibrosis Committee of Quebec (ACFCQ) 2006; 30: 21-23.
  122. Esposito-Festen J, IJsselstijn H, Hop W, van Vliet F, de Jongste J, Tiddens H. Aerosol therapy by pressured metered-dose inhaler-spacer in sleeping young children; to do or not to do? Chest 2006; 130: 487-492.
  123. Tiddens HAWM. Chest computed tomography scans should be considered as a routine investigation in cystic fibrosis. Paediatric Respiratory Reviews 2006; 7: 202-208.
  124. Tiddens HAWM, Standaert TE, Challoner P, Speirs RJ, Kesser KC, Overbeek SE, et al. Effect of dry powder inhaler resistance on the inspiratory flow rates and volumes of Cystic Fibrosis patients of six years and older. J Aerosol Med 2006; 19: 456-465.
  125. Phaff S, Tiddens HAWM, Verbrugh HA, Ott A. Macrolide resistance of Staphylococcus aureus and Haemophilus species associated with long-term azithromycin use in cystic fibrosis. J Antimicrob Chemother 2006; 57: 741-746; Advance Access publ 9 Febr 06.
  126. Esposito-Festen J, IJsselstijn H, Hop W, van Vliet F, de Jongste J, Tiddens H. Aerosol therapy by pressured metered-dose inhaler-spacer in sleeping young children; to do or not to do? Chest 2006; 130: 487-492.
  127. Tiddens HAWM. Chest computed tomography scans should be considered as a routine investigation in cystic fibrosis. Paediatric Respiratory Reviews 2006; 7: 202-208.
  128. Janssens HM, Tiddens HAWM. Aerosol therapy: The special needs of young children. Paedatric Respiratory Reviews 2006; 7S: S83-S85.
  129. Tiddens HAWM, de Jong PA. Update on the application of chest computed tomography scanning to cystic fibrosis. Curr Opin Pulm Med 2006; 12: 433-439.
  130. Tiddens HA, Geller DE, Challoner P, Speirs RJ, Kesser KC, Overbeek SE, Humble D, Shrewsbury SB, Standaert TA. Effect of dry powder inhaler resistance on the inspiratory flow rates and volumes of cystic fibrosis patients of six years and older. J Aerosol Med 2006; 19: 456-465.
  131. de Jong PA, Nakano Y, Hop WC, Long FR, Coxson HO, Paré PD, Tiddens HA. Changes in airway dimensions on computed tomography scans of children with cystic fibrosis. Am J Respir Crit Care Med 2005; 172: 218-224.
  132. Schüepp KG, Jauernig J, Janssens HM, Tiddens HAWM, Straub DA, Stangl R, Keller M, Wildhaber JH. In vitro determination of the optimal particle size for nebulized aerosol delivery to infants. J Aerosol Med 2005; 18: 225-235.
  133. Mouton JW, Jacobs N, Tiddens H, Horrevorts AM. Pharmacodynamics of tobramycin in patients with cystic fibrosis. Diagnost Microbiol Infect Dis 2005; 52: 123-127.
  134. Esposito-Festen J, Ates B, van Vliet F, Hop W, Tiddens H. Aerosol delivery to young children by pMDI-spacer: Is facemask design important? Pediatr Allergy Immunol 2005; 16; 348-353.
  135. van der Wiel EC, Hofhuis W, Holland WPJ, Tiddens HAWM, de Jongste JC, Merkus PJFM. Predictive value of infant lung function testing for airway malacia. Pediatr Pulmonol 2005; 40: 431-436.
  136. Boogaard R, Huijsmans SH, Pijnenburg MW, Tiddens HA, de Jongste JC, Merkus PJ. Tracheomalacia and bronchomalacia in children: incidence and patient characteristics. Chest 2005;128(5):3391-7.
  137. Mouton JW, Jacobs N, Tiddens H, Horrevorts AM. Pharmacodynamics of tobramycin in patients with cystic fibrosis. Diagn Microbiol Infect Dis 2005;52(2):123-127.
  138. Brody AS, Tiddens HA, Castile RG, Coxson HO, de Jong PA, Goldin J, et al. Computed tomography in the evaluation of cystic fibrosis lung disease. Am J Resp Crit Care Med 2005;172:1246-1252. (1st and 2nd author equal contribution)
  139. de Jong PA, Nakano Y, Lequin MH, Tiddens HAWM. Dose reduction for CT in children with cystic fibrosis: is it feasible to reduce the number of images per scan? Pediatr Radiol 2006; 36: 50-53.
  140. de Jong PA, Mayo JR, Golmohammadi K, Nakano Y, Lequin MH, Tiddens HAWM, Aldrich J, Coxson HO, Sin DD. Estimation of cancer mortality associated with repetitive computed  tomography scanning. Am J Respir Crit Care Med 2006; 173: 199-203 (with online supplement).
  141. de Jong PA, Nakano Y, Hop WC, Long FR, Coxson HO, Paré PD, Tiddens HA. Changes in airway dimensions on computed tomograph"

Teaching activities

2009: Professor of Pediatric Pulmonology, Erasmus MC Rotterdam Pediatric Respiratory Medicine.

2011: Visiting professor Cincinnati Children’s Hospital, Department of Radiology (Prof. A. Brody) Cincinnati, USA. Sponsor CFF.

2009 - present: Professor of Paediatric Respiratory Medicine, dedicated to the development of the lung.

2007 - present: Honorary member dept. of Radiology, Erasmus Medical Center.

2006 - 2012: Visiting professor University of Washington School of Medicine (UWSOM), Children’s Hospital & Regional Medical Center, Pediatric Pulmonary Division at the CF Therapeutics Development Network Coordinating Center (Prof. B. Ramsey) Seattle, USA. Sponsor CFF. Theme: Development of end-points.

1994 - present: Pediatric pulmonologist, Dept. of Pediatrics, Subdivision Pediatric Respiratory Medicine (current head: Dr MWH Pijnenburg), Sophia Children's Hospital, Rotterdam.

1991 - 2006: Member of Intensive Care team Dept. of Pediatrics, Sophia Children’s Hospital, Rotterdam

1997 - 2010: Chairman CF-team Erasmus Medical Center. Initiator and fundraiser for setting up bi-annual newsletter, website www.cfsophia.nl, CF-database, annual patient education evening, CF-lounge, etc.

18-10-2017 W.Y. Kuo-Kim, “Advanced Pediatric Chest Computed Tomography. Safe and standardized protocols and sensitive image analysis of cystic fibrosis lung disease”. Erasmus University. PI and promotor.

19-09-2017: W. Bos, “Children in medical research. Ethical challenges”. Erasmus University.

14-12-2016: P. Ciet, “Thoracic Magnetic Resonance Imaging”. Erasmus University. PI and promotor.

23-11-2016: A.C. Bos, “Small airway disease in cystic fibrosis: improving efficacy of treatment”. Erasmus University. PI and promotor.

5/11/2014: L.A. Tepper, “Monitoring Cystic Fibrosis lung disease: chest imaging and patient-related outcome measures”. Erasmus University. PI and promotor.

3/10/2012: E.M. Bakker, “Detection and aerosol treatment of small airway disease in pediatric CF and asthma” PI and promotor.

20-01-2012: M. Loeve, ""Chest Computed Tomography in early and advanced cystic fibrosis lung disease. Optimizing protocols, image analysis and further validation."" Erasmus University, PI and promotor.

9/10/2009:  L.J. van der Giessen, ""Optimisation and assessment of airway clearance in children with Cystic Fibrosis"". Erasmus University. PI and co-promotor.

14-01-2006: J.E. Festen, ""Improving the efficiency of inhalation therapy in young children"". PI and co-promotor.

14-12-2005:P.A. de Jong, ""Monitoring of CF lung disease using computed tomography"". Erasmus University. PI and co-promotor.

19-09-2001:H.M. Janssens, ""Aerosol therapy in young children"". Erasmus University. PI and co-promotor.

Participation in various teaching activities of the department of Pediatrics:

  • Lectures for 2nd and 3rd year medical students;
  • Coaching of junior interns;
  • Coaching of senior interns;
  • Doctoral and medical finals Pediatrics;
  • Minor Pediatric Oncology ≥2009.
  • Optional interns;
  • Optional education for 4th-year medical master students.
  • Graduation projects optional research.
  • Pediatricians and registrars outpatient clinic;
  • Registrars Pediatrics;
  • Registrars Pulmonology (Erasmus MC and LUMC).
  • Lecture Evenings department of Pediatrics;
  • Nursing – training of all nurses in pediatric pulmonology and aerosol treatment.
  • Physiotherapists.
  • Patient education. Annual evening symposium for parents with a child with CF.
  • Bijdrage over auteurschappen tijdens cursus Wetenschappelijke Integriteit voor PhDs.