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Research group/lab

Cupedo lab

Mechanisms driving generation of secondary and tertiary lymphoid organs in humans

About our research group/lab

Our research

The Cupedo Lab studies the development and function of human and mouse innate lymphoid cells. 

Cupedo lab

We are interested in understanding how the interaction between type 3 innate lymphoid cells (ILC3) and their stromal microenvironment shapes biological processes as diverse as lymph node organogenesis and intestinal immunity.

Our ultimate goal is to control and direct ILC3-mediated immunity after intestinal damage to increase mucosal healing in patient with inflammatory bowel diseases or intestinal graft versus host disease.
We combine animal models with studies on primary human tissues and cells allowing for the immediate translation and validation of experimental findings.

Our projects

  • Biology of human LTi cells 
  • Human lymph node stromal cells
  • Microengineering artificial lymph nodes
  • Ectopic germinal center formation by non-Hodgkin lymphomas

Key Publications

Follow this link for our publications.

Our team

Tom Cupedo, groupleader
Natalie Papazian, research technician
Madelon de Jong, PhD student
Zoltan Kellermayer, postdoc