Jump to top menu Jump to main menu Jump to content
Afbeelding man als foto ontbreekt
Principal Investigator

R. (Ruben) Bierings, PhD

  • Department
  • Hematology
  • Focus area
  • Endothelial cell biology, Von Willebrand factor (VWF) biosynthesis and secretion, Weibel-Palade body biogenesis and exocytosis, Rab GTPases and effectors , SNARE proteins, blood outgrowth endothelial cells
Contact   External Profile

About

Introduction

My research focuses on how endothelial cells and platelets secrete hemostatic and inflammatory proteins from their secretory organelles, the endothelial Weibel-Palade bodies and the alpha- and dense granules in platelets. Our aim is to understand how defects in this system lead to bleeding abnormalities in patients.

Field(s) of expertise

  • Endothelial cell biology
  • Von Willebrand factor (VWF) biosynthesis and secretion
  • Weibel-Palade body biogenesis and exocytosis
  • Rab GTPases and effectors
  • SNARE proteins
  • Blood outgrowth endothelial cells

Education and career

Current and previous affiliations

  • 2018 - now Group Leader/Principal Investigator
    • Department of Hematology Erasmus University Medical Center, Rotterdam, Netherlands 
  • 2013 - 2018 Group Leader Department of Molecular and Cellular Hemostasis
    • Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands
  • 2011 - 2013 Senior Postdoc
    • Department of Plasma Proteins Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands 
  • 2007 - 2011 Career Development Fellow
    •  Divisions of Physical Biochemistry and Molecular Neuroendocrinology MRC National Institute for Medical Research, London, United Kingdom
  • 2002 - 2007 PhD Candidate
    • Department of Plasma Proteins CLB-Sanquin Research, Amsterdam, Netherlands 
  • 2001 - 2002 Junior Research Associate
    • Department of Molecular Cellular and Developmental Biology University of California Santa Barbara, Santa Barbara CA, USA

Education 

  • 2002 - 2007 PhD
    • Utrecht University, Utrecht, Netherlands (October 17, 2007) Thesis title: “Sorting out the Weibel-Palade body” Promotor: Prof.dr. K. Mertens 
  • 1996 - 2002 MSc
    • Molecular Sciences, Wageningen University, Netherlands 

Publications

For publications, follow this link.

Teaching activities

Supervised theses as co-promoter

  • April 24, 2020 - Ellie Karampini
    • Title: “Weibel-Palade Body formation and release; An Odyssey through the secretory pathway”, University of Amsterdam
  • June 20, 2019 - Maaike Schillemans
    • Title: “Weibel-Palade body logistics: express delivery in the vasculature”, University of Amsterdam
  • June 18, 2014 - Dorothee van Breevoort
    • Title: “Tuning the SNAREs that regulate Weibel-Palade body exocytosis”, University of Amsterdam
  • April 11, 2014 - Kathinka van Hooren
    • Title: “Molecular mechanisms involved in Weibel-Palade body exocytosis”, University of Amsterdam

Courses

Scholarships, grants and awards

Project grants

  • 2019 Nationale Wetenschapsagenda SYMPHONY
    • “Orchestrating personalised treatment for patients with bleeding disorders” (co-applicant) 
  • 2018 Sanquin Product and Process Development Cellular Products (PPOC18-21)
    • “Pulling platelets to sites of vascular injury” (co-applicant) 
  • 2017 Dutch Thrombosis Foundation (TSN)
    • “The only way is up: polarized secretion of VWF and tethering by adhesion molecules” (head applicant) 
  • 2015 Dutch Thrombosis Foundation (TSN)
    • “Caught in a trap: Unravelling von Willebrand factor extracellular traps” (head applicant)
  • 2012 Landsteiner Foundation for Blood transfusion Research (LSBR)
    • “Vascular gatekeepers” (head applicant)

Personal grants and fellowships

  • 2017 Landsteiner Foundation for Blood transfusion Research (LSBR) Fellowship
    • “Von Willebrand factor secretion from Weibel-Palade bodies: pulling the strings in vascular disease” (personal grant) 
  • 2013 European Hematology Association (EHA) Research Fellowship
    • “Gatekeepers of the vasculature; regulation of Weibel-Palade body exocytosis by syntaxin binding protein 1 (STXBP1)” (personal grant) 
  • 2007 Medical Research Council Career Development Fellowship

My Groups