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Research group/lab

Early identification and treatment of critically ill patients

The focus of the group is to identify patients at risk for deterioration or critical illness from a heterogeneous group of emergency department patients.

About our research group/lab

About the research group

Background information

Reduce sepsis-related morbidity and mortality.

Overall aim

Identify patients at risk for deterioration and provide adequate care.

Research focus areas

Prediction modelling using vital parameters, clinical decision rules, serum and genetic biomarkers.

Key publications

The early identification of disease progression in patients with suspected infection presenting to the emergency department: a multi-centre derivation and validation study.Saeed K, Wilson DC, Bloos F, Schuetz P, van der Does Y, Melander O, Hausfater P, Legramante JM, Claessens YE, Amin D, Rosenqvist M, White G, Mueller B, Limper M, Callejo CC, Brandi A, Macchi MA, Cortes N, Kutz A, Patka P, Yañez MC, Bernardini S, Beau N, Dryden M, van Gorp ECM, Minieri M, Chan L, Rood PPM, Del Castillo JG. (2019).Crit Care. 2019 Feb 8;23(1):40.

Identifying Patients with Bacterial Infections Using a Combination of C-reactive Protein, Procalcitonin, TRAIL and IP-10 in the Emergency Department: a Prospective Cohort Study.Van der Does Y, Rood PPM, Ramakers C, Schuit SCE, Patka P, van Gorp ECM, Limper M. (2018). Clin Microbiol Infect. 2018 Dec;24(12):1297-1304.

Procalcitonin-guided Antibiotic Therapy in Patients with Fever in a General Emergency Department Population: a Multicenter Noninferiority Randomized Clinical Trial (HiTEMP study).Van der Does Y, Limper M, Jie KE, Schuit SCE, Jansen H, Pernot N, van Rosmalen J, Poley MJ, Ramakers C, Patka P, van Gorp ECM, Rood PPM. (2018). Clin Microbiol Infect. 2018 Dec;24(12):1282-1289.

Niet minder antibiotica na procalcitoninemeting op SEH.
Mischa A.M. Huson en Fanny N. Lauw. (2018).

Procalcitonin-Guided Therapy for the Initiation of Antibiotics in the Emergency Department: a Systematic Review. Van der Does Y, Rood PP, Haagsma JA, Patka P, van Gorp EC, Limper M. (2016). Am J Emerg Med. 2016 Jul;34(7):1286-93.

Higher Diagnostic Accuracy and Cost-effectiveness Using a Novel Biomarker in the Treatment of Emergency Medicine Patients with Fever (The HiTEMP Study): a Multicenter Randomized Non-inferiority Study. Van der Does Y, Limper M, Schuit SC, Poley MJ, van Rosmalen J, Ramakers C, Patka P, van Gorp EC, Rood PP. (2016). BMC Emerg Med. 2016 Apr 6;16:17.