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Research group/lab  |  PI M.C. (Marie-Christine) Franken PhD

Speech and language development and disorder

The pathophysiology of many speech and language problems is still not fully understood. Studies investigating the effect of speech and language treatment are scarce

About our research group/lab

Our research group

Why is our group fomed?

This group was formed to contribute to the evidence base of the development of speech and language disorders.

Our aim.

The overall aim of the group is to improve our knowledge of the cause and development of speech and language disorders, and the effect of treatment.

Our focus.

We focus on clinical studies and population based research projects.

Our projects

1. Childhood stuttering.

  • RESTART study- comparing outcomes of two types of early intervention; PhD project (finished) Caroline de Sonneville-Koedoot; ongoing long-term outcome and genetic associations with recovery and persistency.
  • Childhood stuttering and structural brain morphology; Ph D project Simone Koenraads.

2. Speech and Language development in children born very preterm.

  • PRELAN Study - Cohort study children born very preterm 2 -10 years of age; PhD projects Inge van Noort- van der Spek and Lottie Stipdonk.
  • Effect of early intervention for speech sound disorder in very preterm children; running project by Marie-Christine Franken.

3. Associations of language development and other (neuro)developmental outcomes.

  • SEED project - Social InEquality and its Effects on child Development: A study of birth cohorts in the UK, Germany and the Netherlands; PhD project Lisanne Labuschagne.


Language outcome related to brain structures in school-aged preterm children: A systematic review. 
Lottie W Stipdonk, Marie-Christine J P Franken, Jeroen Dudink. (2018). PLoS One. 2018 Jun 4;13(6):e0196607.

Recovery from stuttering in preschool-age children: 9 year outcomes in a clinical population. 
Marie-Christine J P Franken, Simone P C Koenraads, Carike E M Holtmaat, Marc P van der Schroeff. (2018). J Fluency Disord. 2018 Dec;58:35-46.

Comparison of Percentage of Syllables Stuttered With Parent-Reported Severity Ratings as a Primary Outcome Measure in Clinical Trials of Early Stuttering Treatment. 
Mark Onslow, Mark Jones, Sue O'Brian, Ann Packman, Ross Menzies, Robyn Lowe, Simone Arnott, Kate Bridgman, Caroline de Sonneville, Marie-Christine Franken. (2018). J Speech Lang Hear Res. 2018 Apr 17;61(4):811-819.

Auditory brainstem maturation in normal-hearing infants born preterm: a meta-analysis. 
Lottie W Stipdonk, Nynke Weisglas-Kuperus, Marie-Christine Jp Franken, Kazem Nasserinejad, Jeroen Dudink, André Goedegebure. (2016). Dev Med Child Neurol. 2016 Oct;58(10):1009-15.

Direct versus Indirect Treatment for Preschool Children who Stutter: The RESTART Randomized Trial. 
Caroline de Sonneville-Koedoot, Elly Stolk, Toni Rietveld, Marie-Christine Franken. (2015). PLoS One. 2015 Jul 28;10(7):e0133758.

Language functions in preterm-born children: a systematic review and meta-analysis. 
Inge L van Noort-van der Spek, Marie-Christine J P Franken, Nynke Weisglas-Kuperus. (2012). Pediatrics. 2012 Apr;129(4):745-54.


Collaborations within Erasmus MC.

  • Department of Otolaryngology 
  • Neonatology
  • Department of Child and Adolescent  Psychiatry
  • Generation R Study Group
  • iMGZ Maatschappelijke.Gezondheidszorg

Collaborations outside Erasmus MC.

Our team

Principal investigator Marie-Christine Franken PhD


  • M.C. (Marie-Christine) Franken PhD
  • M. (Marc) van der Schroeff MD PhD 
  • I.L. (Inge) van Noort – van der Spek MA
  • L.W. (Lottie) Stipdonk MSc
  • S. P.C. (Simone) Koenraads MD
  • J.E. (Lisanne) Labuschagne MS