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Research project

FUSION study: Coronary CT with FFRct

Status: Ongoing project

This study evaluates the value of adding advanced FFRct assessment to CT scans of coronary arteries.

What we do

About our project

Coronary CT

Patients with stable chest pain undergo Coronary Computed Tomography Angiography (CCTA) as the first line test to detect coronary stenosis. An anatomically significant (>= 50% luminal narrowing) stenosis on CCTA does however not always cause cardiac ischemia (i.e. hemodynamically significant stenosis). CCTA is often followed by invasive coronary angiography (ICA) to assess the hemodynamic significance of the stenosis. However, >=50% stenoses on CCTA often turn out not to be hemodynamically significant on ICA. Fractional Flow Reserve from coronary computed tomography (FFRct) analysis provides additional functional information based on the anatomical CCTA images.


In the randomized controlled FUSION study, we assess if adding FFRct to CCTA can avoid unnecessary invasive coronary angiography (ICA) in stable chest pain patients with a (more than) 50% stenosis on CCTA. 528 patients will be randomized between FFRct and the routine work-up with ICA. The primary outcome measure is the rate of ICA without obstructive coronary stenosis (anatomical narrowing <50% or invasive FFR >0.80) reflecting unnecessary ICA.


The study is led by a team of investigators from Erasmus MC that work closely with colleagues from 5 Dutch hospitals (UMCG, UMCU, Gelre, ADRZ, St Jansdal). Patient enrollment will start in the second half of 2020.


FUSION study


Our research focus

The Cardiac Imaging CT group at Erasmus MC has a strong track record in cardiac imaging research.

Our main areas of interest are:

  1. Ischemic Heart Disease: non-invasive assessment of the coronary arteries.
  2. Heart Valve (Dys)function: use of CT to assess the working mechanisms of prosthetic heart valves and their modes of failure.
  3. Endocarditis: improvement of diagnostic imaging (CT and PET-CT) for endocarditis
  4. Imaging to Improve Cardiac Surgery: use of CT imaging to plan surgical strategy to improve patient outcome.

Funds & Grants

Zorginstituut / ZonMw Veelbelovende Zorg


Internal collaboration (Erasmus MC)

  • Department of Radiology & Nuclear Medicine
  • Department of Cardiology


External collaborations

  • Universitair Medisch Centrum Groningen (UMCG)
  • Universitair Medisch Centrum Utrecht (UMCU)
  • Gelre Ziekenhuis, Apeldoorn
  • Admiraal de Ruyter Ziekenhuis (ADRZ)
  • St Jansdal Ziekenhuis, Harderwijk

Our team