What we do
About our project
About
Newborns who have undergone surgery may suffer from delayed cognitive and motor development even though there are no signs of congenital brain malformation and/or perinatal injury. It is thought that surgery and anesthesiology affect the newborn brain.
What is the aim?
The aim of this study is to show how the different surgical and anesthesiologic approaches affect validated parameters of cerebral oxygenation, autoregulation and neurovascular coupling. In addition, follow-up during the first two and a half years of the newborn’s life will give objective data of the longer-term effects of these interventions.
How will you perform this research?
Continuous a EEG, NIRS and vital parameter measurements will be performed in all subjects, as well as intraoperative transcutaneous CO2 measurements combined with repeatedly obtained arterial blood gas analyses. Perioperative anesthesiologic and intensive care management will be applied according to the guidelines of the CDH-EURO Consortium. The measurement results will create an integrative picture of cerebral activity, cerebral oxygenation, metabolic balance and cerebral autoregulation and give insight in the potential perioperative risk moments for brain injury.
What is the desirable outcome?
This study will create understanding about the potential perioperative risk factors for brain injury. This knowledge will have a positive effect on the perioperative care for all neonates.
Collaborations
Collaborations within Erasmus MC
Collaboration with the departments of Pediatric Surgery, Pediatric Anesthesia and Neonatal/Pediatric ICU.
Collaborations outside of Erasmus MC
Collaboration with four well-organized pediatric surgical centers:
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University Medical Centre Mannheim, Germany
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Bambino Gesu Children's Hospital, Rome, Italy
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University Hospital Leuven, Belgium
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Amalia Children’s Hospital, Radboud UMC Nijmegen, the Netherlands
Publications
Risk Factors of Impaired Neuropsychologic Outcome in School-Aged Survivors of Neonatal Critical Illness.
Leeuwen L, Schiller RM, Rietman AB, van Rosmalen J, Wildschut ED, Houmes RJM, Tibboel D, IJsselstijn H. (2018). Crit Care Med. 2018 Mar;46(3):401-410.
Thoracoscopic versus open repair of CDH in cardiovascular stable neonates.
Costerus S, Zahn K, van de Ven K, Vlot J, Wessel L, Wijnen R. (2016). Surg Endosc. 2016 Jul;30(7):2818-24.
Standardized Postnatal Management of Infants with Congenital Diaphragmatic Hernia in Europe: The CDH EURO Consortium Consensus - 2015 Update.
Snoek KG, Reiss IK, Greenough A, Capolupo I, Urlesberger B, Wessel L, Storme L, Deprest J, Schaible T, van Heijst A, Tibboel D; CDH EURO Consortium. (2016). Neonatology. 2016;110(1):66-74.
Measuring Near-Infrared Spectroscopy Derived Cerebral Autoregulation in Neonates: From Research Tool Toward Bedside Multimodal Monitoring.
Thewissen L, Caicedo A, Lemmers P, Van Bel F, Van Huffel S, Naulaers G. (2018). Front Pediatr. 2018 May 14;6:117.
Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial.
Davidson AJ, Disma N, de Graaff JC, Withington DE, Dorris L, Bell G, Stargatt R, Bellinger DC, Schuster T, Arnup SJ, Hardy P, Hunt RW, Takagi MJ, Giribaldi G, Hartmann PL, Salvo I, Morton NS, von Ungern Sternberg BS, Locatelli BG, Wilton N, Lynn A, Thomas JJ, Polaner D, Bagshaw O, Szmuk P, Absalom AR, Frawley G, Berde C, Ormond GD, Marmor J, McCann ME; GAS consortium. (2016). Lancet. 2016 Jan 16;387(10015):239-50.
Our team
- Sophie Costerus, MD
- Jurgen de Graaff, MD, PhD
- Prof. Dick Tibboel, MD, PhD
- Prof. Rene Wijnen, MD, PhD
