What we do
About our project
Semantic Dementia is uncommon as it does not have a clear heritable component and a relatively homogeneous clinical and pathological presentation. Somatic mutations in the brain have been described to cause neurodevelopmental disorders. The role of these kind of mutations in neurodegenerative disorders is currently unclear.
What is the aim?
We are investigating whether somatic mutations acquired in the brain of semantic dementia patients might contribute or even cause the disease process.
How do we perform this research?
What is the desirable outcome?
Funds & Grants
Outside Erasmus MC
Center for Neurogenomics and Cognitive Research, VU & VUMC Amsterdam, Prof Guus Smit
Prof John van Swieten
Jeroen van Rooij