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Researcher

D. (Daniel) Bos, MD, PhD

Principal Investigator

Assistant Professor and Principal Investigator of Imaging of Arteriosclerosis

  • Department
  • Radiology & Nuclear Medicine, Epidemiology
  • Focus area
  • Imaging in Health Sciences
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About

Introduction

Current position
I hold a position as Assistant Professor in the department of Radiology and Nuclear Medicine and the department of Epidemiology.
 
Current research interests and goals
My research focuses on the interface of arteriosclerosis and neurodegenerative diseases, with a strong emphasis on imaging. Specifically, I aim to obtain relevant biomarkers for improved understanding and prediction of these diseases, and to identify potential targets for intervention strategies. As such, I have developed two main research lines. One of these is focused on the causes and consequences of intracranial arteriosclerosis. In this field, I performed important pioneering-work on the identification and quantification of intracranial carotid artery calcification as one the most important risk factors for clinical stroke. This work has had considerable impact and has also led to an extension of my research horizon towards clinical studies on the value of carotid artery calcification in stroke patients.
My other line of research revolves around optimization of imaging of arteriosclerosis and its related phenotypes. Important aspects within this research line are the early detection of subclinical disease, and development of strategies to maximally leverage existing medical imaging examinations.

Field(s) of expertise

Arteriosclerosis, imaging, epidemiology, stroke

Education and career

Current positions:
 
Feb 2018 - present
Assistant Professor - Imaging of arteriosclerosis
Department of Radiology & Nuclear Medicine, and Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands
 
May 2016 – present
Visiting scientist in Clinical Epidemiology
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA
 
Oct 2014 - present
Imaging Coordinator for European Population Imaging Infrastructure (EPI2)
Biobanking and Biomolecular Resources Research Infrastructure (BBMRI)
Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands
 
Previous positions:
 
Oct 2014 – Feb 2018
Postdoctoral researcher - Research on the etiology and consequences of intracranial vascular disease
Department of Radiology & Nuclear Medicine, and Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands
 
July 2013 – Oct 2014
Resident in Radiology  
Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands
 
Jan 2010 - Dec 2013
PhD-candidate
Dissertation: Atherosclerotic calcification: Determinants and clinical neurological consequences
Department of Radiology & Nuclear Medicine, and Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands
 
Jan 2011 – May 2011
General physician
Het Doktershuis, Ridderkerk, the Netherlands
 
Academic education and degrees:
 
Dec 2013:
Doctorate degree (PhD), Erasmus MC, Rotterdam, the Netherlands
 
Aug 2012:
Master of Science (MSc) in Health Sciences, Netherlands Institute of Health Sciences (NIHES), Rotterdam, the Netherlands
 
Dec 2009:
Medical degree (MD) (cum laude), Erasmus MC, Rotterdam, the Netherlands
 

Publications

Below is a selection of journal articles (for complete list of references please see (https://www.researchgate.net/profile/Daniel_Bos):
 
2019:
Bos D, van der Toorn J, Licher S. Letter by Bos et al regarding article “Intracranial Atherosclerotic
Disease Mechanisms and Therapeutic Implications”. Stroke. 2019;50:e261.
 
Arenillas J, Dieleman N, Bos D. Intracranial arterial wall imaging: techniques, clinical applicability and future perspectives. Int J Stroke. 2019;14(6):564-573.
 
Van der Toorn J, Engelkes S, Ikram M, Ikram M, Vernooij M, Kavousi M, Bos D. Vertebrobasilar artery calcification: Prevalence and risk factors in the general population. Atherosclerosis. 2019;286:46-52.
 
2018:
Compagne C, Clephas P, Majoie C, Roos Y, Berkhemer O, van Oostenbrugge R, van Zwam W, van Es A, Dippel D, van der Lugt A, Bos D. Intracranial carotid artery calcification and effect of endovascular stroke treatment: a MR CLEAN subgroup analysis. Stroke. 2018;49:2961-2968.
 
Mujaj B, Bos D, Muka T, van der Lugt A, Ikram M, Vernooij M, Stricker B, Franco O. Antithrombotic treatment is associated with intraplaque hemorrhage in the atherosclerotic carotid artery: a cross-sectional analysis of The Rotterdam Study. Eur Heart J. 2018: 39:3369-3376.
 
Kockelkoren R, de Vis J, de Jong P, Vernooij M, Mali W, Hendrikse J, Schiestl T, Pellikaan K, van der Lugt A, Bos D. Prevalence and volume of intracranial carotid artery calcification from infancy to old age. JACC. 2018: 72: 582-584.
 
2017:
Bos D, Ikram M, Leening M, Ikram M. The Revised Framingham Stroke Risk Profile in a Primary Prevention Population: The Rotterdam Study. Circulation. 2017; 135: 2207-09.
 
Bos D, Vernooij M, Shahzad R, Kavousi M, Hofman A, Van Walsum T, Deckers J, Ikram M, Heeringa J, Franco O, Van der Lugt A, Leening M. Epicardial Fat Volume and the Risk of Atrial Fibrillation in the General Population Free of Cardiovascular Disease: The Rotterdam Study. JACC: Cardiovasc Imaging. 2017. pii: S1936-87831019-1.
 
Bos D*, Hernández-Pérez M*,  Dorado L, Pellikaan K, Vernooij M,  López-Cancio E, Pérez de la Ossa N, Gomis M, Castaño C, Munuera J, Puig J, Millán M, Dávalos A. Intracranial Carotid Artery Calcification relates to recanalization and clinical outcome after mechanical thrombectomy. Stroke. 2017; 48:342-347
 
2016:
Bos D*, Wolff L*, Darwish Murad S, Franco O, Krestin G, Hofman A, Vernooij M, Van der Lugt A. Liver fat is related to cardiovascular risk factors and subclinical vascular disease: the Rotterdam Study. Eur Heart J Cardiovasc Imaging. 2016. Pii: jew174.
 
Adams H, Ikram M, Vernooij M, Van Dijk A, Hofman A, Uitterlinden A, Van Duijn C, Koudstaal P, Franco O, Van der Lugt A, Bos D. Heritability and genome-wide association analyses of intracranial carotid artery calcification: the Rotterdam Study. Stroke. 2016; 47:912-917.
 
Bos D, Poels M, Adams H, Akoudad S, Cremer L, Zonneveld H, Hoogendam Y, Verhaaren B, Verlinden V, Verbruggen J, Peymani A, Hofman A, Krestin G, Vincent A, Feelders R, Koudstaal P, Van der Lugt A, Ikram M, Vernooij M. Prevalence, clinical management and natural course of incidental findings on brain MRI:
the population-based Rotterdam Scan Study. Radiology. 2016; 160218.
 
2015:
Ikram MA,  Van der Lugt A, Niessen W, Koudstaal P, Krestin G, Hofman A, Bos D, Vernooij M. The Rotterdam Scan Study: design update 2016 and main findings. Eur J Epid. 2015; 30:1299-1315.
 
Bos D, Leening M, Kavousi M, Hofman A, Franco O, Van der Lugt A, Vernooij M, Ikram M. Comparison of atherosclerotic calcification in major vessel beds on the risk of all-cause and cause-specific mortality: the Rotterdam Study. Circ Cardiovasc Imaging. 2015; Dec. pii: e003843.
 
Bos D, Shahzad R, Van Walsum T, Van Vliet L, Franco O, Hofman A, Niessen W, Vernooij M, Van der Lugt A. Epicardial fat volume is related to atherosclerotic calcification in multiple vessel beds. Eur Heart J Cardiovasc Imaging. 2015; 16:1264-1269.
 
2014:
Bos D, Vernooij M, de Bruijn R, Koudstaal P, Hofman A, Franco O, Van der Lugt A, Ikram M. Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline. Alzheimers Dement. 2014; 11:639-47.e1.
 
Bos D, Portegies M, Van der Lugt A, Bos M, Koudstaal P, Hofman A, Krestin G, Franco O, Vernooij M, Ikram M. Intracranial carotid artery atherosclerosis and the risk of stroke in whites: the Rotterdam Study. JAMA Neurol. 2014; 71:405-411.
 
 

Teaching activities

My teaching activities have rapidly increased during the past years and range from lectures at the Junior Med School to intensive tutoring of MSc-students in Medicine or Health Sciences (over 20 students completed their research under my supervision during the past 5 years) and supervision of PhD-candidates (currently supervising 3 PhD-candidates).
Specific highlights of my teaching activities include the following. First, since 2016, I am  giving one of the opening lectures of the prestigious Junior Med School-programme for talented high school students that are interested in studying Medicine and performing scientific research. Second, since 2016, I am part of the teaching staff of the summer course entitled “Study design in Clinical Epidemiology (EPI210)” in the Master of Public Health-programme at the Harvard School of Public Health in Boston. Third, since 2018, I have become part of the core staff of the course “Clinical translation of Epidemiology (CE01)” which is part of the Master of Science-programme provided by the Netherlands Institute of Health Sciences. Finally, since 2019, I am a tutor for first-year Medicine students in the core curriculum of Medicine at the Erasmus University Rotterdam.
 

Other positions

1. Board positions
Journal editor
• Guest Editor Frontiers in Neurology
• Associate Editor for the Journal of Alzheimer’s Disease
Scientific board member
• International Society on Intracranial Atherosclerosis, including the organizational board membership of the two-yearly International Conference on Intracranial Atherosclerosis

2. Active Academic Memberships
• Member of the ESC Council on Stroke  
• Member of the Dutch Society of Epidemiology (VvE)  
• Member of the European Stroke Organisation (ESO)  
• Member of the Society for Epidemiologic Research (SER)
• Member of the Radiological Society of the Netherlands (NVvR)               
• Member of the European Society of Radiology (ESR)              
 
3. Abstract reviewing committee member
• International Stroke Conference 2020 (August 2019)
• Europe Biobank Week 2019 “Novel Novel Molecular & Medical Imaging Technologies in Biobanking” (October 2019)
• International meeting of The International Society of Vascular Behavioural and Cognitive Disorders 2016(Sept 2016)
            
4. Reviewer of grant proposals for funding instances
• Joint Stroke Association/British Heart Foundation               
• German Research Foundation                     

5. Consortium memberships
• BBMRI Metabolomics Consortium       
• International Stroke Genetics Consortium (ISGC) – Neuro imaging  
• Alzheimer Cohorts Consortium (ACC)        
• Enhancing Neuro Imaging Genetics Through Meta-Analysis (ENIGMA)            
 

Scholarships, grants, and awards

1. Scholarships
Principle Investigator  
Erasmus MC MRACE Grant for a PhD-project (2019)
Erasmus MC Academic Career Development Programme (2019)
BrightFocus Foundation Alzheimer Grant (2017)
Personal Fellowship Alzheimer Nederland (2017)
Personal Fellowship Harvard T.H. Chan School of Public Health (2016)
Alzheimer Nederland Personal International Research Fund (2016)
Van Leersum Grant Royal Netherlands Academy of Arts and Sciences (2015)
Trustfonds Travel Grant (2011)
  
Co-applicant  
Netherlands Organisation for Scientific Research (NWO) - Big Data Grant (2019)
Dutch Brain Foundation(Hersenstichting) Grant (2017)
Erasmus MC MRACE Grant (2017)
NWO Visitors Travel Grant (2017)
  
2. Awards  
Lourens Penning Prize (Dutch Radiological Society) (2016)
Best Scientific Paper Award (Dutch Radiological Society) (2011)