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Researcher

D. (Daniel) Bos, MD, PhD

Principal Investigator

Associate Professor and Principal Investigator of Imaging of Arteriosclerosis

  • Department
  • Radiology & Nuclear Medicine, Epidemiology
  • Focus area
  • Imaging in Health Sciences
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About

Introduction

Current position
I hold a position as Associate Professor in the department of Radiology and Nuclear Medicine and the department of Epidemiology.
 
Current research interests and goals
My research focuses on the interface of arteriosclerosis and neurodegenerative diseases, with a strong emphasis on imaging. Specifically, I aim to obtain relevant biomarkers for improved understanding and prediction of these diseases, and to identify potential targets for intervention strategies. As such, I have developed two main research lines. One of these is focused on the causes and consequences of intracranial arteriosclerosis. In this field, I performed important pioneering-work on the identification and quantification of intracranial carotid artery calcification as one the most important risk factors for clinical stroke. This work has had considerable impact and has also led to an extension of my research horizon towards clinical studies on the value of carotid artery calcification in stroke patients.
My other line of research revolves around optimization of imaging of arteriosclerosis and its related phenotypes. Important aspects within this research line are the early detection of subclinical disease, and development of strategies to maximally leverage existing medical imaging examinations.

Field(s) of expertise

Arteriosclerosis, imaging, epidemiology, stroke

Education and career

Current positions:
 

Aug 2021 - present
Associate Professor - Imaging of arteriosclerosis
Department of Radiology & Nuclear Medicine, and Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands

Jan 2021 – present
Guest-professor Cardiovascular Imaging
Department of Cardiovascular Sciences, KU Leuven, Belgium

May 2016 – present
Visiting scientist in Clinical Epidemiology
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA

 
 
 
Previous positions:

Feb 2018 – July 2021
Assistant Professor - Imaging of arteriosclerosis
Department of Radiology & Nuclear Medicine, and Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands

Oct 2014 – Jan 2021
Imaging Coordinator for European Population Imaging Infrastructure (EPI2)
Biobanking and Biomolecular Resources Research Infrastructure (BBMRI)
Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands

 
Oct 2014 – Feb 2018
Postdoctoral researcher - Research on the etiology and consequences of intracranial vascular disease
Department of Radiology & Nuclear Medicine, and Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands
 
July 2013 – Oct 2014
Resident in Radiology  
Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, the Netherlands
 
Jan 2010 - Dec 2013
PhD-candidate
Dissertation: Atherosclerotic calcification: Determinants and clinical neurological consequences
Department of Radiology & Nuclear Medicine, and Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands
 
Jan 2011 – May 2011
General physician
Het Doktershuis, Ridderkerk, the Netherlands

 

 

Academic education and degrees:

Dec 2013:
Doctorate degree (PhD), Erasmus MC, Rotterdam, the Netherlands
 
Aug 2012:
Master of Science (MSc) in Health Sciences, Netherlands Institute of Health Sciences (NIHES), Rotterdam, the Netherlands
 
Dec 2009:
Medical degree (MD) (cum laude), Erasmus MC, Rotterdam, the Netherlands
 

Publications

Below is a selection of journal articles (for complete list of references please click link).

 

2021:
Atherosclerotic Carotid Plaque Composition and Incident Stroke and Coronary Events.
Bos D, Arshi B, van den Bouwhuijsen QJA, Ikram MK, Selwaness M, Vernooij MW, Kavousi M, van der Lugt A.
J Am Coll Cardiol. 2021 Mar 23;77(11):1426-1435.

Advances in Multimodality Carotid Plaque Imaging: AJR Expert Panel Narrative Review
Bos D, van Dam-Nolen DHK, Gupta A, Saba L, Saloner D, Wasserman BA, van der Lugt A.
AJR Am J Roentgenol. 2021 Jan 13. doi: 10.2214/AJR.20.24869.

Association of White Matter Lesions and Outcome After Endovascular Stroke Treatment
Luijten SPR, Bos D, Compagne KCJ, Wolff L, Majoie CBLM, Roos YBWEM, van Zwam WH, van Oostenbrugge RJ, Dippel DWJ, van der Lugt A, van Es ACGM; MR CLEAN trial investigators. Neurology. 2021 Jan 19;96(3):e333-e342

2020:
Aortic Arch Calcification and the Risk of Cancer: A Population-Based Cohort Study
van der Toorn JE, van der Willik KD, Ruiter R, Vernooij MW, Stricker BHC, Schagen SB, Ikram MA, Kavousi M, Bos D.
Front Oncol. 2020 Sep 11;10:1700

Sex-specific distributions and determinants of thoracic aortic diameters in the elderly
Bons LR, Rueda-Ochoa OL, El Ghoul K, Rohde S, Budde RP, Leening MJ, Vernooij MW, Franco OH, van der Lugt A, Roos-Hesselink JW, Kavousi M, Bos D.
Heart. 2020 Jan;106(2):133-139.

Serum insulin levels are associated with vulnerable plaque components in the carotid artery: the Rotterdam Study
Mujaj B, Bos D, Kavousi M, van der Lugt A, Staessen JA, Franco OH, Vernooij MW.
Eur J Endocrinol. 2020 Mar;182(3):343-350. 

 
2019:
Disease Mechanisms and Therapeutic Implications”. 
Bos D, van der Toorn J, Licher S. Letter by Bos et al regarding article “Intracranial Atherosclerotic.
Stroke. 2019;50:e261. 
 
Intracranial arterial wall imaging: techniques, clinical applicability and future perspectives. .
Arenillas J, Dieleman N, Bos D. 
Int J Stroke. 2019;14(6):564-573
 
Vertebrobasilar artery calcification: Prevalence and risk factors in the general population
Van der Toorn J, Engelkes S, Ikram M, Ikram M, Vernooij M, Kavousi M, Bos D.
Atherosclerosis. 2019;286:46-52.
 
2018:
Intracranial carotid artery calcification and effect of endovascular stroke treatment: a MR CLEAN subgroup analysis.
Compagne C, Clephas P, Majoie C, Roos Y, Berkhemer O, van Oostenbrugge R, van Zwam W, van Es A, Dippel D, van der Lugt A, Bos D. 
Stroke. 2018;49:2961-2968.
 
Antithrombotic treatment is associated with intraplaque hemorrhage in the atherosclerotic carotid artery: a cross-sectional analysis of The Rotterdam Study.
Mujaj B, Bos D, Muka T, van der Lugt A, Ikram M, Vernooij M, Stricker B, Franco O. 
Eur Heart J. 2018: 39:3369-3376.
 
Prevalence and volume of intracranial carotid artery calcification from infancy to old age.
Kockelkoren R, de Vis J, de Jong P, Vernooij M, Mali W, Hendrikse J, Schiestl T, Pellikaan K, van der Lugt A, Bos D. 
JACC. 2018: 72: 582-584.
 
2017:
The Revised Framingham Stroke Risk Profile in a Primary Prevention Population: The Rotterdam Study.
Bos D, Ikram M, Leening M, Ikram M. 
Circulation. 2017; 135: 2207-09.
 
Epicardial Fat Volume and the Risk of Atrial Fibrillation in the General Population Free of Cardiovascular Disease: The Rotterdam Study. 
Bos D, Vernooij M, Shahzad R, Kavousi M, Hofman A, Van Walsum T, Deckers J, Ikram M, Heeringa J, Franco O, Van der Lugt A, Leening M.
JACC: Cardiovasc Imaging. 2017. pii: S1936-87831019-1.
 
Intracranial Carotid Artery Calcification relates to recanalization and clinical outcome after mechanical thrombectomy.
Bos D*, Hernández-Pérez M*,  Dorado L, Pellikaan K, Vernooij M,  López-Cancio E, Pérez de la Ossa N, Gomis M, Castaño C, Munuera J, Puig J, Millán M, Dávalos A. 
Stroke. 2017; 48:342-347
 
2016:
Liver fat is related to cardiovascular risk factors and subclinical vascular disease: the Rotterdam Study.
Bos D*, Wolff L*, Darwish Murad S, Franco O, Krestin G, Hofman A, Vernooij M, Van der Lugt A. 
Eur Heart J Cardiovasc Imaging. 2016. Pii: jew174.
 
Heritability and genome-wide association analyses of intracranial carotid artery calcification: the Rotterdam Study.
Adams H, Ikram M, Vernooij M, Van Dijk A, Hofman A, Uitterlinden A, Van Duijn C, Koudstaal P, Franco O, Van der Lugt A, Bos D. 
Stroke. 2016; 47:912-917.
 
Prevalence, clinical management and natural course of incidental findings on brain MRI: the population-based Rotterdam Scan Study.
Bos D, Poels M, Adams H, Akoudad S, Cremer L, Zonneveld H, Hoogendam Y, Verhaaren B, Verlinden V, Verbruggen J, Peymani A, Hofman A, Krestin G, Vincent A, Feelders R, Koudstaal P, Van der Lugt A, Ikram M, Vernooij M. 
Radiology. 2016; 160218.
 
2015:
The Rotterdam Scan Study: design update 2016 and main findings.
Ikram MA,  Van der Lugt A, Niessen W, Koudstaal P, Krestin G, Hofman A, Bos D, Vernooij M. 
Eur J Epid. 2015; 30:1299-1315.
 
Comparison of atherosclerotic calcification in major vessel beds on the risk of all-cause and cause-specific mortality: the Rotterdam Study. 
Bos D, Leening M, Kavousi M, Hofman A, Franco O, Van der Lugt A, Vernooij M, Ikram M. 
Circ Cardiovasc Imaging. 2015; Dec. pii: e003843.
 
Epicardial fat volume is related to atherosclerotic calcification in multiple vessel beds.
Bos D, Shahzad R, Van Walsum T, Van Vliet L, Franco O, Hofman A, Niessen W, Vernooij M, Van der Lugt A. 
Eur Heart J Cardiovasc Imaging. 2015; 16:1264-1269.
 
2014:
Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline.
Bos D, Vernooij M, de Bruijn R, Koudstaal P, Hofman A, Franco O, Van der Lugt A, Ikram M. 
Alzheimers Dement. 2014; 11:639-47.e1.
 
Bos D, Portegies M, Van der Lugt A, Bos M, Koudstaal P, Hofman A, Krestin G, Franco O, Vernooij M, Ikram M. Intracranial carotid artery atherosclerosis and the risk of stroke in whites: the Rotterdam Study. JAMA Neurol. 2014; 71:405-411.
 
 

Teaching activities

My teaching activities have rapidly increased during the past years and range from lectures at the Junior Med School to intensive tutoring of MSc-students in Medicine or Health Sciences (over 20 students completed their research under my supervision during the past 5 years) and supervision of PhD-candidates (currently supervising 3 PhD-candidates).
Specific highlights of my teaching activities include the following. First, since 2016, I am  giving one of the opening lectures of the prestigious Junior Med School-programme for talented high school students that are interested in studying Medicine and performing scientific research. Second, since 2016, I am part of the teaching staff of the summer course entitled “Study design in Clinical Epidemiology (EPI210)” in the Master of Public Health-programme at the Harvard School of Public Health in Boston. Third, since 2018, I have become part of the core staff of the course “Clinical translation of Epidemiology (CE01)” which is part of the Master of Science-programme provided by the Netherlands Institute of Health Sciences. Finally, since 2019, I am a tutor for first-year Medicine students in the core curriculum of Medicine at the Erasmus University Rotterdam.
 

Other positions

1. Board positions
Journal editor
• Guest Editor Frontiers in Neurology
• Associate Editor for the Journal of Alzheimer’s Disease
Scientific board member
• International Society on Intracranial Atherosclerosis, including the organizational board membership of the two-yearly International Conference on Intracranial Atherosclerosis

2. Active Academic Memberships
• Member of the ESC Council on Stroke  
• Member of the Dutch Society of Epidemiology (VvE)  
• Member of the European Stroke Organisation (ESO)  
• Member of the Society for Epidemiologic Research (SER)
• Member of the Radiological Society of the Netherlands (NVvR)               
• Member of the European Society of Radiology (ESR)              
 
3. Abstract reviewing committee member
• International Stroke Conference 2020 (August 2019)
• Europe Biobank Week 2019 “Novel Novel Molecular & Medical Imaging Technologies in Biobanking” (October 2019)
• International meeting of The International Society of Vascular Behavioural and Cognitive Disorders 2016(Sept 2016)
            
4. Reviewer of grant proposals for funding instances
• Joint Stroke Association/British Heart Foundation               
• German Research Foundation                     

5. Consortium memberships
• BBMRI Metabolomics Consortium       
• International Stroke Genetics Consortium (ISGC) – Neuro imaging  
• Alzheimer Cohorts Consortium (ACC)        
• Enhancing Neuro Imaging Genetics Through Meta-Analysis (ENIGMA)            
 

Scholarships, grants, and awards

1. Grants

PI:
Alzheimer Association Research Grant (2021) 
Erasmus MC MRACE Grant for a PhD-project (2019)
Erasmus MC Academic Career Development Programme (2019)
BrightFocus Foundation Alzheimer Grant (2017)
Personal Fellowship Alzheimer Nederland (2017)
Personal Fellowship Harvard T.H. Chan School of Public Health (2016)
Alzheimer Nederland Personal International Research Fund (2016)
Van Leersum Grant Royal Netherlands Academy of Arts and Sciences (2015)

Co-applicant
World Cancer Research Fund (2021)
European Horizon 2020 Research Grant (2020)
Netherlands Organisation for Scientific Research (NWO) - Big Data Grant (2019)
Dutch Brain Foundation(Hersenstichting) Grant (2017)
Erasmus MC MRACE Grant (2017)
NWO Visitors Travel Grant (2017)
  
2. Awards  
Lourens Penning Prize (Dutch Radiological Society) (2016)
Best Scientific Paper Award (Dutch Radiological Society) (2011)



 

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