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A. (Anne) Flier


  • Department
  • Orthopedics & Sports Medicine
  • Focus area
  • Disease Moddelling, iPSC, Cyclic Tensile Strain, Mechanotransduction



After my bachelor Biology (Leiden) and my master Infection and Immunity (Utrecht) I wanted to dive into more fundamental research related to disease modelling with a close connection to genetics. Thus, in 2023’s spring I started with my PhD in the department of Orthopaedics and Sport medicine. The aim of my project is to study how genotype and phenotype affect mechanotransduction in chondrogenic cells. My project is part of the LoaD consortium in which we are investigating how molecular variation influences the loading capacity of articular joints with special focus on knee osteoarthritis. The overall goal of the consortium is to, in the future, be able to advice patients what kind of physical activity they should practice to keep their joints healthy. 

Education and career

2017-2020 BSc Biology at Leiden University. 
2019-2020 Internship Insitute Biology, Annemarie Meijer lab, Mycobacterium-induced cell death.  
2020-2023 MSc Infection & Immunity at Utrecht University.
2020-2021 Internship University Medical Center Utrecht, Strijp-Rooijakkers lab, monoclonal antibodies against Staphylococcus epidermidis infection. 
2022 Internship Dana Farber Cancer Institute/Harvard Medical School, Dougan lab, CD8+ recognition of ductal pancreatic cancer and its metastases.  


Publications on Pubmed

Publications & Profile on PURE

My Groups