About our department
Our research
Osteoarthritis
Osteoarthritis is a progressive and degenerative disease of the joints that causes impaired mobility and pain. It affects all joint tissues: cartilage, bone, synovium, tendons and ligaments. How these changes are orchestrated is not fully understood. We currently have no cure for osteoarthritis. At the end stage, joint replacement surgery is the main treatment option. By gaining more insight in osteoarthritis etiology, we aim to develop new treatments that can prevent the development of OA or delay the need for joint replacement surgery.
Sports & traumatic injuries
More and more patients are consulting sports physicians and orthopedic surgeons for injuries of cartilage, bone, tendon or ligaments due to trauma or sports. When these injuries are left untreated, there is a significant risk for the development of degenerative joint diseases. Our research focusses on the effectiveness of different treatment options and the development of new treatments to regenerate the damaged structures.
Skeletal growth and development
Changes in the joint shape and bone density in the developing joint are studied to relate observed joint changes to clinical symptoms, progression of the disease, environmental factors and genetic factors. To improve treatment, it is of importance to understand the processes that take place when the joint develops. Pathologies of the hip that occur in childhood and adolescence, such as dysplasia, CAM impingement, Perthes disease and slipped capital femoral epiphysis, have our special attention.Principal Investigators
Head of Department: Prof. dr. J.A.N. Verhaar
Osteoarthritis
Basic research
Prof. dr. G.J.V.M. van Osch
Clinical research
Prof. dr. S.M.A. Bierma-Zeinstra
Dr. M. Reijman
Dr. J. Waarsing
Dr. D.E. Meuffels
Dr. J. van Oldenrijk
Dr. J. Colaris
Skeletal growth and development
Basis research
Prof. dr. G.J.V.M. van Osch
Dr. R. Narcisi
Clinical research
Prof. dr. S.M.A. Bierma-Zeinstra
Dr. M. Reijman
Dr. R. Agricola
Sports- and traumatic injuries
Basic research
Prof. dr. G.J.V.M. van Osch
Dr. R. Narcisi
Clinical research
Prof. dr. S.M.A. Bierma-Zeinstra
Dr. M. Reijman
Dr. J. Waarsing
Dr. D.E. Meuffels
Dr. J. Colaris
Dr. R.J. de Vos
Dr. T. Piscaer
Research lines
Research Line "Osteoarthritis"
- Study early phases of osteoarthritis to stop progression to chronic end-stage osteoarthritis or reverse this process
- Improve the surgical and non-surgical treatment of OA
- Develop new biological treatment methods
- Develop methods for the early-stage recognition of OA
Research Line "Sport and Traumatic Injuries"
- Determine risk factors for – and the long-term consequences of – sports injuries and trauma-related injuries
- Improve surgical and non-surgical treatment options for sport and traumatic injuries
- Improve and develop regenerative treatments for cartilage, bone and tendon/ligament injuries
Research Line "Skeletal Growth and Development"
- Unravel the etiopathogenesis of joint development and the development of deformities during growth
- Improve treatment choices for children with growth and developmental disorders
Connective Tissue Repair Lab
Doctoral theses & Publications
Doctoral thesis
Eijgenraam SM (2020 januari 22). The Meniscus Matters - Novel insights into imaging and treatment of meniscal pathology. Prom/coprom: Prof. S.M.A. Bierma-Zeinstra, Dr. E.H.G. Oei, Dr. M. Reijman en Dr. D.E. Meuffels https://repub.eur.nl/pub/120794
Suijkerbuijk MAM (2020 januari 8) Hamstring Tendon Regeneration Following Harvest for Anterior Cruciate Ligament Reconstruction Prom/coprom: Prof.dr.G.J.V.M. van Osch, Dr. D.E. Meuffels, Dr. Y.M. Bastiaansen-Jenniskens https://repub.eur.nl/pub/121752
v Oldenrijk J. (2019 mei 21) Short Incisions and Short Stems in Total Hip Arthroplasty. Prom/coprom: Prof.dr.C.N. van Dijk, dr. M.U. Schafroth, dr. R.W. Poolman https://www.orthopeden.org/downloads/654/proefschrift-jakob-van-oldenrijk.pdf?view=active
Fahmy-Garcia S. (2019, mei 2019) Towards in situ bone tissue engineering : an injectable system for protein delivery. Prom/coprom: Prof.dr. G.J.V.M. van Osch, Prof. Dr.J.P.T.M. van Leeuwen, Dr. E. Farrell, Dr. M. van Driel https://repub.eur.nl/pub/116479
Mumcuoglu, Z. D. (2018, mei 9). Development of an injectable slow release system for bone morphogenetic protein-2. Prom./coprom.: Prof. Dr. G.J.V.M. van Osch & S.G. Kluijtmans. https://repub.eur.nl/pub/105787
Pleumeekers, M. M. (2018, juni 29). Face it: Cell-based therapy for the reconstruction of cartilage defects in the head and neck area. Prom./coprom.: Prof. Dr. G.J.V.M. van Osch & KS Stok. https://repub.eur.nl/pub/105992
Utomo, L. (2018, september 18). Macrophage Phenotypes in Degenerative Joint Diseases. Prom./coprom.: Prof. Dr. G.J.V.M. van Osch, Prof. Dr. J.A.N. Verhaar & Dr. Y.M. Bastiaansen-Jenniskens. https://repub.eur.nl/pub/106448
Boersema, G.S.A. (2017, September 13). Major Abdominal Surgical Complications : Innovative Approaches. Supervisor(s): Prof. Dr. J.F. Lange, Prof. Dr. G.J. Kleinrensink, Dr. Y.M. Bastiaansen-Jenniskens & Prof.Dr. J. Jeekel. - https://repub.eur.nl/pub/100857
Dorleijn, D.M.J. (2017, January 25). Hip Osteoarthritis : symptomatic presentation and non-operative treatment. Supervisor(s): Prof. Dr. S.M.A. Bierma-Zeinstra, Dr. P.A.J. Luijsterburg & Dr. P.K. Bos. - https://epubs.ogc.nl/?epub=d.dorleijn%20(Metis)
Grotenhuis, N. (2017, October 11). New Models for Patient-specific Evaluation of the Effect of Biomaterials on Macrophages. Supervisor(s): Prof. Dr. G.J.V.M. van Osch, Prof. Dr. J.F. Lange & Dr. Y.M. Bastiaansen-Jenniskens. - https://repub.eur.nl/pub/101852
Vos, BC de (2017, February 7). Battling Obesity : Efforts in preventing knee osteoarthritis. Supervisor(s): Prof. Dr. S.M.A. Bierma-Zeinstra & Dr. J. Runhaar. - https://repub.eur.nl/pub/95488
Wei, W. (2017, October 20). Adipose tissue and the knee? : role of inflammation on joint degeneration and cartilage repair. Supervisor(s): Prof. Dr. G.J.V.M. van Osch, Prof. Dr. J.A.N. Verhaar & Dr. Y.M. Bastiaansen-Jenniskens. - https://repub.eur.nl/pub/102357
Windt, A.E. van der (2017, March 29). Calcineurin Inhibition at Physiological Osmolarity: Toward improving cartilage regeneration. EUR (209 pag.) Supervisor(s): Prof. Dr. Ir. H.H. Weinans & Prof. Dr. J.A.N. Verhaar. - https://repub.eur.nl/pub/98466
Kroon, L. de (2017, October 23). A dive into TGHß signaling components during generation and degeneration of cartilage. Supervisors; van der Kraam PM, Van Osch GJVM, Narcisi R, Blaney Davidson N. - No link available