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Orthopaedics and Sports Medicine

Our goal is to keep people mobile as long as possible by improving therapeutic interventions. We study risk factors and (molecular) processes of skeletal growth & development disorders, sport & traumatic injuries and osteoarthritis.

About our department

Our research


Osteoarthritis is a progressive and degenerative disease of the joints that causes impaired mobility and pain. It affects all joint tissues: cartilage, bone, synovium, tendons and ligaments. How these changes are orchestrated is not fully understood. We currently have no cure for osteoarthritis. At the end stage, joint replacement surgery is the main treatment option. By gaining more insight in osteoarthritis etiology, we aim to develop new treatments that can prevent the development of OA or delay the need for joint replacement surgery.


Sports & traumatic injuries

More and more patients are consulting sports physicians and orthopedic surgeons for injuries of cartilage, bone, tendon or ligaments due to trauma or sports. When these injuries are left untreated, there is a significant risk for the development of degenerative joint diseases. Our research focusses on the effectiveness of different treatment options and the development of new treatments to regenerate the damaged structures.


Skeletal growth and development

Changes in the joint shape and bone density in the developing joint are studied to relate observed joint changes to clinical symptoms, progression of the disease, environmental factors and genetic factors. To improve treatment, it is of importance to understand the processes that take place when the joint develops. Pathologies of the hip that occur in childhood and adolescence, such as dysplasia, CAM impingement, Perthes disease and slipped capital femoral epiphysis, have our special attention.

Principal Investigators

Research lines

Research Line "Osteoarthritis"

  • Study early phases of osteoarthritis to stop progression to chronic end-stage osteoarthritis or reverse this process
  • Improve the surgical and non-surgical treatment of OA
  • Develop new biological treatment methods
  • Develop methods for the early-stage recognition of OA


Research Line "Sport and Traumatic Injuries"

  • Determine risk factors for – and the long-term consequences of – sports injuries and trauma-related injuries 
  • Improve surgical and non-surgical treatment options for sport and traumatic injuries
  • Improve and develop regenerative treatments for cartilage, bone and tendon/ligament injuries


Research Line "Skeletal Growth and Development"

  • Unravel the etiopathogenesis of joint development and the development of deformities during growth
  • Improve treatment choices for children with growth and developmental disorders



Beweegbord project

More information will follow


Research project: To study whether a high volume injection without corticosteroids improves clinical outcome in addition to usual care for adults with chronic midportion Achilles tendinopathy.


More information will follow


To develop a 'Mobility and Physical activity Telemonitoring System' and determine its (cost-) effectiveness


To examine the effect of a multifactorial, online injury prevention programme on the number of running-related injuries (RRIs) in recreational runners.


Research project: To compare the effectiveness of progressive tendon-loading exercises (PTLE) with eccentric exercise therapy (EET) in patients with patellar tendinopathy.

Microfet2 Stabilizer project

Development of a stabillizer for the Microfet2, a hand-held dynometer to measure accurately and reliable the forse of quadriceps muscle. This project is in collaboration with Create4Care and the department of Medical Technology of the Erasmus MC


To evaluate the cost-effectiveness of the optimized, treat-to-target PPT strategy in TKA and THA patients compared to usual PPT. The hypothesis is that with the optimized strategy superior functional outcome can be achieved to usual care, with lower costs (superiority study).


Research towards individualized treatment recommendation in patients with an anterior cruciate ligament rupture.


Patients with a clinically suspected scaphoid fracture and normal initial radiographs are treated with 2 weeks below-elbow cast. However, only 10% of these patients has eventually a scaphoid fracture. Therefore, we are treating most patients unnecessary.


Telefysio is a long-term phased dynamic project to develop, implement and evaluate a digital physical therapy application to be used before, during, and after hospitalization.

Treatment of Achilles tendinopathy – a living systematic review and network meta-analysis

Research project: Evaluation of the comparative effectiveness of all available treatments for Achilles tendinopathy.

Doctoral theses

Doctoral thesis

Eggerding, V. (2021 June).  Optimal treatment for patients after anterior cruciate ligament rupture. Prom/Coprom:  Prof.dr. S.M. Bierma-Zeinstra, Dr. M. Reijman, Dr. D.E. Meuffels.  https://repub.eur.nl/pub/135515


van Klij, P. (2021 Maart 10). The development of the non-perfect hip in young athletes. Prom/Coprom: Prof.dr. J.A.N. Verhaar, Dr. R. Agricola.Repub P. van Klij, embargo


Vainieri, ML (2021 februari 18). Towards Cartilage Regeneration: Biomaterial-Assisted Cell-Free Approach in a Physiological Joint-like Environment. Prom/Coprom: Prof.dr. G.J.V.M. van Osch. https://repub.eur.nl/pub/131288


Van der Vlist, AC (2021 januari 20) Achilles Tendinopathy: risk factors, imaging, and treatment. Prom/Coprom: Prof.dr. J.A.N. Verhaar, Dr. R.J. de Vos. https://repub.eur.nl/pub/133300


Fokkema, T. (2020 December 2). Prognosis and Prevention of Injuries in Recreational Runners. Prom/Coprom: Prof.dr.S.M. Bierma-Zeinstra, M. van Middelkoop, R.J. de Vos https://repub.eur.nl/pub/124642


Tolk, JJ  (2020, juni 2). Expectations and Outcome in Knee and Hip Arthroplasty. Prom/Coprom: S.M. Bierma-Zeinstra, M. Reijman, R.P.A. Janssen. https://repub.eur.nl/pub/127241


Eijgenraam SM (2020 januari 22). The Meniscus Matters - Novel insights into imaging and treatment of meniscal pathology. Prom/coprom: Prof. S.M.A. Bierma-Zeinstra, Dr. E.H.G. Oei, Dr. M. Reijman en Dr. D.E. Meuffels https://repub.eur.nl/pub/120794


Suijkerbuijk MAM (2020 januari 8) Hamstring Tendon Regeneration Following Harvest for Anterior Cruciate Ligament Reconstruction Prom/coprom: Prof.dr.G.J.V.M. van Osch, Dr. D.E. Meuffels, Dr. Y.M. Bastiaansen-Jenniskens https://repub.eur.nl/pub/121752


v Oldenrijk J. (2019 mei 21) Short Incisions and Short Stems in Total Hip Arthroplasty. Prom/coprom: Prof.dr.C.N. van Dijk, dr. M.U. Schafroth, dr. R.W. Poolman https://www.orthopeden.org/downloads/654/proefschrift-jakob-van-oldenrijk.pdf?view=active


Fahmy-Garcia S.  (2019, mei 2019) Towards in situ bone tissue engineering : an injectable system for protein delivery. Prom/coprom: Prof.dr. G.J.V.M. van Osch, Prof. Dr.J.P.T.M. van Leeuwen, Dr. E. Farrell, Dr. M. van Driel https://repub.eur.nl/pub/116479


Mumcuoglu, Z. D. (2018, mei 9). Development of an injectable slow release system for  bone morphogenetic protein-2. Prom./coprom.: Prof. Dr. G.J.V.M. van Osch & S.G. Kluijtmans. https://repub.eur.nl/pub/105787


Pleumeekers, M. M.   (2018, juni 29). Face it: Cell-based therapy for the reconstruction of cartilage defects in the head and neck area. Prom./coprom.: Prof. Dr. G.J.V.M. van Osch & KS Stok. https://repub.eur.nl/pub/105992


Utomo, L.  (2018, september 18). Macrophage Phenotypes in Degenerative Joint Diseases. Prom./coprom.: Prof. Dr. G.J.V.M. van Osch, Prof. Dr. J.A.N. Verhaar & Dr. Y.M. Bastiaansen-Jenniskens. https://repub.eur.nl/pub/106448


Boersema, G.S.A. (2017, September 13). Major Abdominal Surgical Complications : Innovative Approaches. Supervisor(s): Prof. Dr. J.F. Lange, Prof. Dr. G.J. Kleinrensink, Dr. Y.M. Bastiaansen-Jenniskens & Prof.Dr. J. Jeekel. - https://repub.eur.nl/pub/100857


Dorleijn, D.M.J. (2017, January 25). Hip Osteoarthritis : symptomatic presentation and non-operative treatment. Supervisor(s): Prof. Dr. S.M.A. Bierma-Zeinstra, Dr. P.A.J. Luijsterburg & Dr. P.K. Bos. - https://epubs.ogc.nl/?epub=d.dorleijn%20(Metis)


Grotenhuis, N. (2017, October 11). New Models for Patient-specific Evaluation of the Effect of Biomaterials on Macrophages. Supervisor(s): Prof. Dr. G.J.V.M. van Osch, Prof. Dr. J.F. Lange & Dr. Y.M. Bastiaansen-Jenniskens. - https://repub.eur.nl/pub/101852


Vos, BC de (2017, February 7). Battling Obesity : Efforts in preventing knee osteoarthritis. Supervisor(s): Prof. Dr. S.M.A. Bierma-Zeinstra & Dr. J. Runhaar. - https://repub.eur.nl/pub/95488


Wei, W. (2017, October 20). Adipose tissue and the knee? : role of inflammation on joint degeneration and cartilage repair. Supervisor(s): Prof. Dr. G.J.V.M. van Osch, Prof. Dr. J.A.N. Verhaar & Dr. Y.M. Bastiaansen-Jenniskens. - https://repub.eur.nl/pub/102357


Windt, A.E. van der (2017, March 29). Calcineurin Inhibition at Physiological Osmolarity: Toward improving cartilage regeneration. EUR (209 pag.) Supervisor(s): Prof. Dr. Ir. H.H. Weinans & Prof. Dr. J.A.N. Verhaar. - https://repub.eur.nl/pub/98466


Kroon, L. de  (2017, October 23). A dive into TGHß signaling components during generation and degeneration of cartilage. Supervisors; van der Kraam PM, Van Osch GJVM, Narcisi R, Blaney Davidson N. - No link available


Connective Tissue Repair Lab

News, events and awards

Our news


On June 17, 2021 Vincent Eggerding defended his thesis Entitled: Optimal treatment for patients after anterior cruciate ligament rupture”.

 In this thesis, we first discuss the clinical results and cost-effectiveness analysis of the randomized controlled trial for patients after an anterior cruciate ligament (ACL) rupture. Patients were either treated with early reconstruction or exercise therapy for 3 months, after which acl reconstruction was possible in case of symptoms. Half of the patients treated with exercise therapy eventually underwent surgery. Patients who were successfully treated non-operatively had a similar outcome to those treated with an early ACL reconstruction. In our cost-effectity analuysis we found that it is not cost-effective to treat all patients after an anterior cruciate ligament rupture with an early reconstruction.

Furthermore, in the thesis we look at the relationship between the anatomical shape of the knee and clinical outcome after an anterior cruciate ligament rupture, whether we can predict which patients need a reconstruction and whether it is of added value to use computer guidance in the reconstruction of a cruciate ligament.

Boekje Vincent




Postdoc Researchers

PhD students

Basic research

Mauricio Ferrao Blanco
Sohrab Khatab
Maarten Leijs
Chantal Voskamp
Tim Wesdorp
Jietao Xu

Clinical research

Britt Barvelink
Michiel van Buuren
Abigail Cohen
Eline van Es
Sabine van der Graaff
Lichelle Groot
Mark van Outeren
Joost Verschueren
Floris de Vos
Annika Willems