Orthopaedics and Sports Medicine

Osteoarthritis

Osteoarthritis is a progressive and degenerative disease of the joints that causes impaired mobility and pain. It affects all joint tissues: cartilage, bone, synovium, tendons and ligaments. How these changes are orchestrated is not fully understood. We currently have no cure for osteoarthritis. At the end stage, joint replacement surgery is the main treatment option. By gaining more insight in osteoarthritis etiology, we aim to develop new treatments that can prevent the development of OA or delay the need for joint replacement surgery.

 

Sports & traumatic injuries

More and more patients are consulting sports physicians and orthopedic surgeons for injuries of cartilage, bone, tendon or ligaments due to trauma or sports. When these injuries are left untreated, there is a significant risk for the development of degenerative joint diseases. Our research focusses on the effectiveness of different treatment options and the development of new treatments to regenerate the damaged structures.

 

Skeletal growth and development

Changes in the joint shape and bone density in the developing joint are studied to relate observed joint changes to clinical symptoms, progression of the disease, environmental factors and genetic factors. To improve treatment, it is of importance to understand the processes that take place when the joint develops. Pathologies of the hip that occur in childhood and adolescence, such as dysplasia, CAM impingement, Perthes disease and slipped capital femoral epiphysis, have our special attention.

Head of Department: Prof. dr. J.A.N. Verhaar

Osteoarthritis
Basic research
Prof. dr. G.J.V.M. van Osch

Clinical research
Prof. dr. S.M.A. Bierma-Zeinstra
Prof.dr.ir. J. Harlaar
Dr. M. Reijman
Dr. D.E. Meuffels
Dr. J. van Oldenrijk
Dr. J. Colaris


Skeletal growth and development
Basis research
Prof. dr. G.J.V.M. van Osch
Dr. R. Narcisi

Clinical research
Prof. dr. S.M.A. Bierma-Zeinstra
Dr. M. Reijman
Prof. dr. ir. J. Harlaar
Dr. R. Agricola

Sports- and traumatic injuries
Basic research
Prof. dr. G.J.V.M. van Osch
Dr. R. Narcisi

Clinical research
Prof. dr. S.M.A. Bierma-Zeinstra
Dr. M. Reijman
Prof. dr. ir. J. Harlaar
Dr. D.E. Meuffels
Dr. J. Colaris
Dr. R.J. de Vos
Dr. T. Piscaer

 

Research Line "Osteoarthritis"

• Study early phases of osteoarthritis to stop progression to chronic end-stage osteoarthritis or reverse this process
• Improve the surgical and non-surgical treatment of OA
• Develop new biological treatment methods
• Develop methods for the early-stage recognition of OA

 

Research Line "Sport and Traumatic Injuries"

• Determine risk factors for – and the long-term consequences of – sports injuries and trauma-related injuries 
• Improve surgical and non-surgical treatment options for sport and traumatic injuries
• Improve and develop regenerative treatments for cartilage, bone and tendon/ligament injuries

 

Research Line "Skeletal Growth and Development"

• Unravel the etiopathogenesis of joint development and the development of deformities during growth
• Improve treatment choices for children with growth and developmental disorders

 

Doctoral thesis

Eijgenraam SM (2020 januari 22). The Meniscus Matters - Novel insights into imaging and treatment of meniscal pathology. Prom/coprom: Prof. S.M.A. Bierma-Zeinstra, Dr. E.H.G. Oei, Dr. M. Reijman en Dr. D.E. Meuffels https://repub.eur.nl/pub/120794

 

Suijkerbuijk MAM (2020 januari 8) Hamstring Tendon Regeneration Following Harvest for Anterior Cruciate Ligament Reconstruction Prom/coprom: Prof.dr.G.J.V.M. van Osch, Dr. D.E. Meuffels, Dr. Y.M. Bastiaansen-Jenniskens https://repub.eur.nl/pub/121752

 

v Oldenrijk J. (2019 mei 21) Short Incisions and Short Stems in Total Hip Arthroplasty. Prom/coprom: Prof.dr.C.N. van Dijk, dr. M.U. Schafroth, dr. R.W. Poolman https://www.orthopeden.org/downloads/654/proefschrift-jakob-van-oldenrijk.pdf?view=active

 

Fahmy-Garcia S.  (2019, mei 2019) Towards in situ bone tissue engineering : an injectable system for protein delivery. Prom/coprom: Prof.dr. G.J.V.M. van Osch, Prof. Dr.J.P.T.M. van Leeuwen, Dr. E. Farrell, Dr. M. van Driel https://repub.eur.nl/pub/116479

 

Mumcuoglu, Z. D. (2018, mei 9). Development of an injectable slow release system for  bone morphogenetic protein-2. Prom./coprom.: Prof. Dr. G.J.V.M. van Osch & S.G. Kluijtmans. https://repub.eur.nl/pub/105787

 

Pleumeekers, M. M.   (2018, juni 29). Face it: Cell-based therapy for the reconstruction of cartilage defects in the head and neck area. Prom./coprom.: Prof. Dr. G.J.V.M. van Osch & KS Stok. https://repub.eur.nl/pub/105992

 

Utomo, L.  (2018, september 18). Macrophage Phenotypes in Degenerative Joint Diseases. Prom./coprom.: Prof. Dr. G.J.V.M. van Osch, Prof. Dr. J.A.N. Verhaar & Dr. Y.M. Bastiaansen-Jenniskens. https://repub.eur.nl/pub/106448

 

Boersema, G.S.A. (2017, September 13). Major Abdominal Surgical Complications : Innovative Approaches. Supervisor(s): Prof. Dr. J.F. Lange, Prof. Dr. G.J. Kleinrensink, Dr. Y.M. Bastiaansen-Jenniskens & Prof.Dr. J. Jeekel. - https://repub.eur.nl/pub/100857

 

Dorleijn, D.M.J. (2017, January 25). Hip Osteoarthritis : symptomatic presentation and non-operative treatment. Supervisor(s): Prof. Dr. S.M.A. Bierma-Zeinstra, Dr. P.A.J. Luijsterburg & Dr. P.K. Bos. - https://epubs.ogc.nl/?epub=d.dorleijn%20(Metis)

 

Grotenhuis, N. (2017, October 11). New Models for Patient-specific Evaluation of the Effect of Biomaterials on Macrophages. Supervisor(s): Prof. Dr. G.J.V.M. van Osch, Prof. Dr. J.F. Lange & Dr. Y.M. Bastiaansen-Jenniskens. - https://repub.eur.nl/pub/101852

 

Vos, BC de (2017, February 7). Battling Obesity : Efforts in preventing knee osteoarthritis. Supervisor(s): Prof. Dr. S.M.A. Bierma-Zeinstra & Dr. J. Runhaar. - https://repub.eur.nl/pub/95488

 

Wei, W. (2017, October 20). Adipose tissue and the knee? : role of inflammation on joint degeneration and cartilage repair. Supervisor(s): Prof. Dr. G.J.V.M. van Osch, Prof. Dr. J.A.N. Verhaar & Dr. Y.M. Bastiaansen-Jenniskens. - https://repub.eur.nl/pub/102357

 

Windt, A.E. van der (2017, March 29). Calcineurin Inhibition at Physiological Osmolarity: Toward improving cartilage regeneration. EUR (209 pag.) Supervisor(s): Prof. Dr. Ir. H.H. Weinans & Prof. Dr. J.A.N. Verhaar. - https://repub.eur.nl/pub/98466

 

Kroon, L. de  (2017, October 23). A dive into TGHß signaling components during generation and degeneration of cartilage. Supervisors; van der Kraam PM, Van Osch GJVM, Narcisi R, Blaney Davidson N. - No link available

 

Connective Tissue Repair Lab

 

Prof. dr. Verhaar has retired March 26 and received a royal decoration ‘Offcier van Oranje Nassau’ from the mayor of his city of Barendrecht

Defenses

On June 17, 2021 Vincent Eggerding will defend his thesis Entitled: Optimal treatment for patients after anterior cruciate ligament rupture”.

His para nymphs are Eline van Es, e.vanes@erasmusmc.nl and  Rob van Bekkum,  robvanbekkum@hotmail.com

In this thesis, we first discuss the clinical results and cost-effectiveness analysis of the randomized controlled trial for patients after an anterior cruciate ligament (ACL) rupture. Patients were either treated with early reconstruction or exercise therapy for 3 months, after which acl reconstruction was possible in case of symptoms. Half of the patients treated with exercise therapy eventually underwent surgery. Patients who were successfully treated non-operatively had a similar outcome to those treated with an early ACL reconstruction. In our cost-effectity analuysis we found that it is not cost-effective to treat all patients after an anterior cruciate ligament rupture with an early reconstruction.

Furthermore, in the thesis we look at the relationship between the anatomical shape of the knee and clinical outcome after an anterior cruciate ligament rupture, whether we can predict which patients need a reconstruction and whether it is of added value to use computer guidance in the reconstruction of a cruciate ligament.

 

On Thursday 18 February 2021 Letizia Vainieri defended her thesis entitled "Towards cartilage regeneration: Biomaterial-assisted cell-free approach in a physiological joint-like environment".

On Wednesday March 10, 2021 Pim van Klij defended his thesis Entitled: " The development of the non-perfect hip in young athletes’.

 

Niamh Fahy

Shorouk Fahmy Garcia  (hospitality agreement)

Pedro Diaz Payno

Michele Fenu

Mike Broeders

Erin Macri

Kavitha Sivasubramaniyan (hospitality agreement)

 

Basic research
Chantal Voskamp
Mauricio Ferrao Blanco
Tim Wesdorp
Maarten Leijs
Sohrab Khatab
Letizia Vainieri
Jietao Xu

Clinical research

Abigail Cohen
Annika Willems
Britt Barvelink
Michiel van Buuren
Lichelle Groot
Joost Verschueren
Mark van Outeren
Floris de Vos
Sabine van der Graaff