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Orthopaedics and Sports Medicine

Our goal is to keep people mobile as long as possible by improving therapeutic interventions. We study risk factors and (molecular) processes of skeletal growth & development disorders, sport & traumatic injuries and osteoarthritis.

About our Department

Our research


Osteoarthritis is a progressive and degenerative disease of the joints that causes impaired mobility and pain. It affects all joint tissues: cartilage, bone, synovium, tendons and ligaments. How these changes are orchestrated is not fully understood. We currently have no cure for osteoarthritis. At the end stage, joint replacement surgery is the main treatment option. By gaining more insight in osteoarthritis etiology, we aim to develop new treatments that can prevent the development of OA or delay the need for joint replacement surgery.


Sports & traumatic injuries

More and more patients are consulting sports physicians and orthopedic surgeons for injuries of cartilage, bone, tendon or ligaments due to trauma or sports. When these injuries are left untreated, there is a significant risk for the development of degenerative joint diseases. Our research focusses on the effectiveness of different treatment options and the development of new treatments to regenerate the damaged structures.


Skeletal growth and development

Changes in the joint shape and bone density in the developing joint are studied to relate observed joint changes to clinical symptoms, progression of the disease, environmental factors and genetic factors. To improve treatment, it is of importance to understand the processes that take place when the joint develops. Pathologies of the hip that occur in childhood and adolescence, such as dysplasia, CAM impingement, Perthes disease and slipped capital femoral epiphysis, have our special attention.

Principal Investigators

Research lines

Research Line "Osteoarthritis"

  • Study early phases of osteoarthritis to stop progression to chronic end-stage osteoarthritis or reverse this process
  • Improve the surgical and non-surgical treatment of OA
  • Develop new biological treatment methods
  • Develop methods for the early-stage recognition of OA


Research Line "Sport and Traumatic Injuries"

  • Determine risk factors for – and the long-term consequences of – sports injuries and trauma-related injuries 
  • Improve surgical and non-surgical treatment options for sport and traumatic injuries
  • Improve and develop regenerative treatments for cartilage, bone and tendon/ligament injuries


Research Line "Skeletal Growth and Development"

  • Unravel the etiopathogenesis of joint development and the development of deformities during growth
  • Improve treatment choices for children with growth and developmental disorders



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Beweegbord project

More information will follow

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Research project: To study whether a high volume injection without corticosteroids improves clinical outcome in addition to usual care for adults with chronic midportion Achilles tendinopathy.

Healthy Joints

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Description will follow


To develop a 'Mobility and Physical activity Telemonitoring System' and determine its (cost-) effectiveness

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To examine the effect of a multifactorial, online injury prevention programme on the number of running-related injuries (RRIs) in recreational runners.


Identifying New Treatment targets for Osteoarthritis using multi-omic data and next generation personalised human in vitro models

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Evaluation of juvenile osteochondritis dissecans in a population-based cohort and its association with multiple potential risk factors.

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Research project: To compare the effectiveness of progressive tendon-loading exercises (PTLE) with eccentric exercise therapy (EET) in patients with patellar tendinopathy.


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Microfet2 Stabilizer project

Development of a stabillizer for the Microfet2, a hand-held dynamometer to measure accurately and reliable the force of quadriceps muscle. This project is in collaboration with Create4Care and the department of Medical Technology of the Erasmus MC




To evaluate the cost-effectiveness of the optimized, treat-to-target PPT strategy in TKA and THA patients compared to usual PPT. The hypothesis is that with the optimized strategy superior functional outcome can be achieved to usual care, with lower costs (superiority study).

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Research towards individualized treatment recommendation in patients with an anterior cruciate ligament rupture.



Patients with a clinically suspected scaphoid fracture and normal initial radiographs are treated with 2 weeks below-elbow cast. However, only 10% of these patients has eventually a scaphoid fracture. Therefore, we are treating most patients unnecessary.



Telefysio is a long-term phased dynamic project to develop, implement and evaluate a digital physical therapy application to be used before, during, and after hospitalization.

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Treatment of Achilles tendinopathy – a living systematic review and network meta-analysis

Research project: Evaluation of the comparative effectiveness of all available treatments for Achilles tendinopathy.

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WalkWell Gait reTrainer

The project evaluates a wearable device, the WalkWell Gait reTrainer, for personalized gait retraining to improve daily life for knee osteoarthritis patients

World COACH Consortium

Worldwide collaboration of prospective studies to advance the principles of hip osteoarthritis in order to discover personalized prevention and treatment modalities

Doctoral theses

Doctoral thesis


Wesdorp M.A. (2024, January) Promoting endogenous repair in osteochondral defects: Exploring therapeutic strategies and the impact of inflammation Pure Eur.nl


Willems J.A. (2024 April) Bone, Union and Osteoarthritis Pure Eur.nl




Rooij de J.D. (2023, January)   Nucleoplasty: A new treatment option for cervical radicular pain due to a disc herniation.Pure.Eur.nl


Kuijk K.S.R. (2023, March): Cruciate ligament rupture and the role of radiological knee shape. Prom/Coprom: Prof.dr. S.M.A. Bierma-Zeinstra, D.E. Meuffels.Pure.Eur.nl


Voskamp C. (2023, April): Cartilage Tissue Engineering. Prom/Coprom: Prof.dr. G.J.V.M. van Osch, Dr. R. Narcisi. Pure.Eur.nl


Pkric A. (2023, January): Advancement in total elbow arthroplasty care. Prom/Coprom: Prof.dr. D. Eygendaal, Dr. B. The, Dr. C.J.A. van Bergen. Pure.eur.nl




Ferrao Blanco M. 2022, October) Pharmacolocal treatments for osteoarthritis - Emerging therapeutic strategies targeting chondrocyte hypertrophy and inflammation. Prom/Coprom: Prof.dr. G.J.V.M. van Osch, Dr. R. Narcisi. Pure.eur.nl


van Egmond J. (2022, October) Optimizing Fast-Track Protocols for Primary Total Knee Arthroplasty. Rotterdam: Erasmus University Rotterdam. PRom/Coprom: Prof.dr. J.A.N. Verhaar, Dr. N.M.C. Mathijssen. Pure.eur,nl




Leijs, M. (2021, December). Intra-Articular Application of Mesenchymal Stem Cell Therapy for Osteoarthritis — The Next Step: Optimization of Therapeutic Capacity and Applicability. Prom/Coprom: Prof.dr. G.J.V.M. van Osch, Dr. M. Bernsen, Dr. P.K. Bos. https://repub.eur.nl/pub/137032


Eggerding, V. (2021, June).  Optimal treatment for patients after anterior cruciate ligament rupture. Prom/Coprom:  Prof.dr. S.M. Bierma-Zeinstra, Dr. M. Reijman, Dr. D.E. Meuffels.  https://repub.eur.nl/pub/135515


van Klij, P. (2021, March 10). The development of the non-perfect hip in young athletes. Prom/Coprom: Prof.dr. J.A.N. Verhaar, Dr. R. Agricola.Repub P. van Klij, embargo


Vainieri, ML (2021, February 18). Towards Cartilage Regeneration: Biomaterial-Assisted Cell-Free Approach in a Physiological Joint-like Environment. Prom/Coprom: Prof.dr. G.J.V.M. van Osch. https://repub.eur.nl/pub/131288


Van der Vlist, AC (2021, January 20) Achilles Tendinopathy: risk factors, imaging, and treatment. Prom/Coprom: Prof.dr. J.A.N. Verhaar, Dr. R.J. de Vos. https://repub.eur.nl/pub/133300




Fokkema, T. (2020, December 2). Prognosis and Prevention of Injuries in Recreational Runners. Prom/Coprom: Prof.dr.S.M. Bierma-Zeinstra, M. van Middelkoop, R.J. de Vos https://repub.eur.nl/pub/124642


Tolk, JJ  (2020, June 2). Expectations and Outcome in Knee and Hip Arthroplasty. Prom/Coprom: S.M. Bierma-Zeinstra, M. Reijman, R.P.A. Janssen. https://repub.eur.nl/pub/127241


Eijgenraam SM (2020, January 22). The Meniscus Matters - Novel insights into imaging and treatment of meniscal pathology. Prom/coprom: Prof. S.M.A. Bierma-Zeinstra, Dr. E.H.G. Oei, Dr. M. Reijman en Dr. D.E. Meuffels https://repub.eur.nl/pub/120794


Suijkerbuijk MAM (2020, January 8) Hamstring Tendon Regeneration Following Harvest for Anterior Cruciate Ligament Reconstruction Prom/coprom: Prof.dr.G.J.V.M. van Osch, Dr. D.E. Meuffels, Dr. Y.M. Bastiaansen-Jenniskens https://repub.eur.nl/pub/121752




v Oldenrijk J. (2019, May 21) Short Incisions and Short Stems in Total Hip Arthroplasty. Prom/coprom: Prof.dr.C.N. van Dijk, dr. M.U. Schafroth, dr. R.W. Poolman https://www.orthopeden.org/downloads/654/proefschrift-jakob-van-oldenrijk.pdf?view=active


Fahmy-Garcia S.  (2019, May 2019) Towards in situ bone tissue engineering : an injectable system for protein delivery. Prom/coprom: Prof.dr. G.J.V.M. van Osch, Prof. Dr.J.P.T.M. van Leeuwen, Dr. E. Farrell, Dr. M. van Driel https://repub.eur.nl/pub/116479


Mumcuoglu, Z. D. (2018, May 9). Development of an injectable slow release system for  bone morphogenetic protein-2. Prom./coprom.: Prof. Dr. G.J.V.M. van Osch & S.G. Kluijtmans. https://repub.eur.nl/pub/105787


Pleumeekers, M. M.   (2018, juni 29). Face it: Cell-based therapy for the reconstruction of cartilage defects in the head and neck area. Prom./coprom.: Prof. Dr. G.J.V.M. van Osch & KS Stok. https://repub.eur.nl/pub/105992


Utomo, L.  (2018, september 18). Macrophage Phenotypes in Degenerative Joint Diseases. Prom./coprom.: Prof. Dr. G.J.V.M. van Osch, Prof. Dr. J.A.N. Verhaar & Dr. Y.M. Bastiaansen-Jenniskens. https://repub.eur.nl/pub/106448


Boersema, G.S.A. (2017, September 13). Major Abdominal Surgical Complications : Innovative Approaches. Supervisor(s): Prof. Dr. J.F. Lange, Prof. Dr. G.J. Kleinrensink, Dr. Y.M. Bastiaansen-Jenniskens & Prof.Dr. J. Jeekel. - https://repub.eur.nl/pub/100857


Dorleijn, D.M.J. (2017, January 25). Hip Osteoarthritis : symptomatic presentation and non-operative treatment. Supervisor(s): Prof. Dr. S.M.A. Bierma-Zeinstra, Dr. P.A.J. Luijsterburg & Dr. P.K. Bos. - https://epubs.ogc.nl/?epub=d.dorleijn%20(Metis)


Grotenhuis, N. (2017, October 11). New Models for Patient-specific Evaluation of the Effect of Biomaterials on Macrophages. Supervisor(s): Prof. Dr. G.J.V.M. van Osch, Prof. Dr. J.F. Lange & Dr. Y.M. Bastiaansen-Jenniskens. - https://repub.eur.nl/pub/101852


Vos, BC de (2017, February 7). Battling Obesity : Efforts in preventing knee osteoarthritis. Supervisor(s): Prof. Dr. S.M.A. Bierma-Zeinstra & Dr. J. Runhaar. - https://repub.eur.nl/pub/95488


Wei, W. (2017, October 20). Adipose tissue and the knee? : role of inflammation on joint degeneration and cartilage repair. Supervisor(s): Prof. Dr. G.J.V.M. van Osch, Prof. Dr. J.A.N. Verhaar & Dr. Y.M. Bastiaansen-Jenniskens. - https://repub.eur.nl/pub/102357


Windt, A.E. van der (2017, March 29). Calcineurin Inhibition at Physiological Osmolarity: Toward improving cartilage regeneration. EUR (209 pag.) Supervisor(s): Prof. Dr. Ir. H.H. Weinans & Prof. Dr. J.A.N. Verhaar. - https://repub.eur.nl/pub/98466


Kroon, L. de  (2017, October 23). A dive into TGHß signaling components during generation and degeneration of cartilage. Supervisors; van der Kraam PM, Van Osch GJVM, Narcisi R, Blaney Davidson N. - No link available


Connective Tissue Repair Lab

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