About
Introduction
My field of expertise in research is ICU pharmacology and medication safety. I work together with ICU medical staff members in unravelling questions about ICU pharmacology. Another research field is medication safety. I joined multiple projects about this topic.
- My thesis (2010) involved pharmacokinetics, pharmacodynamics and pharmacogenetics of proton pump inhibitors. My PhD project was supervised by Prof Dr Ernst Kuipers.
- After my thesis I specialized in Intensive Care clinical pharmacology, especially in the topics pharmacokinetics of antibiotics and the efficacy of haloperidol in delirium.
Field(s) of expertise
- Clinical pharmacology;
- Medication safety;
- Intensive care pharmacology;
- Pharmacokinetics, pharmacodynamics and pharmacogenetics.
Education and career
- Pharmacy, University of Utrecht.
- PhD, Erasmus MC, Rotterdam.
- BROK.
- BKO.
Publications
A complete overview of publications can be found here
Recent Findings
Previous studies in the lab have shown that autologous dendritic cells pulsed with allogenic tumor cell lysate was able to induce peripheral T cell activation and tumor-reactive T cell responses in patients with mesothelioma and pancreatic cancer. Current research focuses on how to initiate an effective immune response in the tumor as well as the tumor-draining lymph node using dendritic cell vaccination. Furthermore, we are studying novel approaches for (personalized) vaccination. In addition, we have identified T cell characteristics that underlie clinical efficacy of immune check inhibitors or chemotherapeutic agents in mesothelioma. The selected publications below give an impression of our work.
Teaching activities
Lots of experience in teaching medical students, nurses, MDs in clinical pharmacology.
Other positions
Assistant professor.
Scholarships, grants, and awards
Multiple zonMw grants ICU and pharmacy.
