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Principal Investigator

Prof. L.J.W. (Luc) van der Laan, PhD

Professor, Head of Laboratory (LETIS)




The Laboratory of Experimental Transplantation and Intestinal Surgery (LETIS) accommodates experimental and translational research on tissue injury, infection and regeneration of liver grafts during organ transplantation with a strong focus on organoid technology, disease modeling and tissue engineering.

Education and career

Luc van der Laan studied Molecular and Cell Biology at the University of Amsterdam and, in 1998, received his PhD in Immunology at the Free University, Amsterdam. He worked for three years as a post-doc in the lab of Prof. Dan Salomon at The Scripps Research Institute, La Jolla, California/USA, studying islets transplantation and xenogenic infections. In 2002 he became faculty member at the Department of Surgery, Erasmus MC-University Medical Center Rotterdam and was positioned at the Laboratory of Gastroenterology & Hepatology to continue research on transplantation and viral infections. Dr. Van der Laan is full professor in Liver Regenerative Medicine and Head of the Laboratory of Experimental Transplantation and Intestinal Surgery (LETIS).


Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids.

Marsee A, Roos FJM, Verstegen MMA; HPB Organoid Consortium, Gehart H, de Koning E, Lemaigre F, Forbes SJ, Peng WC, Huch M, Takebe T, Vallier L, Clevers H, Spee B/van der Laan LJW Cell Stem Cell. 2021 May 6;28(5):816-832


Bile Duct Repair in Human Liver Grafts: Effective Cholangiocyte Organoid Engraftment and Plasticity.

van der Laan LJW, Roos FJM, Verstegen MMA. Hepatology. 2021 May 2. doi: 10.1002/hep.31877.


Human Bile Contains Cholangiocyte Organoid-Initiating Cells Which Expand as Functional Cholangiocytes in Non-canonical Wnt Stimulating Conditions.

Roos FJM, Verstegen MMA, Muñoz Albarinos L, Roest HP, Poley JW, Tetteroo GWM, IJzermans JNM, van der Laan LJW. Front Cell Dev Biol. 2021 Feb 9;8:630492.


Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease.

Verstegen MMA, Roos FJM, Burka K, Gehart H, Jager M, de Wolf M, Bijvelds MJC, de Jonge HR, Ardisasmita AI, van Huizen NA, Roest HP, de Jonge J, Koch M, Pampaloni F, Fuchs SA, Schene IF, Luider TM, van der Doef HPJ, Bodewes FAJA, de Kleine RHJ, Spee B, Kremers GJ, Clevers H, IJzermans JNM, Cuppen E, van der Laan LJW. Sci Rep. 2020 Dec 14;10(1):21900.

First Report on Ex Vivo Delivery of Paracrine Active Human Mesenchymal Stromal Cells to Liver Grafts During Machine Perfusion.

Verstegen MMA, Mezzanotte L, Ridwan RY, Wang K, de Haan J, Schurink IJ, Sierra Parraga JM, Hoogduijn M, Kessler BM, Huang H, Hall SRR, Ijzermans JNM, Löwik CWGM, van der Laan LJW, de Jonge J. Transplantation. 2020 Jan;104(1):e5-e7.


Luc van der Laan in PUBMED 

Luc van der Laan in PURE

Teaching activities

- Tweedejaars keuzeonderwijs 'Regeneratieve Geneeskunde voor de Dokters van Morgen'

- Minor Regenerative Medicine

- PhD course Stem Cells, Organoids & Regenerative Medicine

- Lecturer Medicine, Klinische Technologie, Regenerative Medicine (TU Delft)

Other positions

  • 2012 - 2016: Councilor of the Dutch Transplantation Society (NTV) and NTV-representative in the Dutch Federation of Biomedical Societies (FEDERA)
  • 2012 - 2020: Member of the educational Committee of the Erasmus Postgraduate School Molecular Medicine
  • 2015 - present: Committee member of the International Society of Liver Transplantation (ILTS)
  • 2019 - present: Workgroup Leader at the Medical Delta Program 'Regenerative Medicine 4D'
  • Luc van der Laan served as Associated Editor for Liver Transplantation and is currently on the editorial board of three journals.

My Groups