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Brigitta Laksono
Researcher

Dr. B.M. (Brigitta) Laksono, PhD

Postdoctoral researcher

  • Focus area
  • Comparative Pathology and Pathogenesis
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About

Introduction

I am a postdoctoral researcher in the Department of Viroscience in the group of Dr Debby van Riel (also known as the RielScience team). I am interested in studying how viruses cause diseases. My current research focus is understanding how enterovirus D68, which is a respiratory virus, can spread outside the respiratory tract and causes diseases and complications in other tissues or organs, such as in muscles, gut, heart or brain. My other main interest is how immune cells, that are supposed to clear viral infection, can contribute to the appearance and severity of diseases.

Field(s) of expertise

Viral pathogenesis

Education and career

During my doctorate study, I investigated how morbilliviruses, such as measles virus and canine distemper virus, cause immune suppression. I received my doctorate degree from Erasmus University of Rotterdam in 2022. 

Publications

  • Sooksawasdi Na Ayudhya S, Sips GJ, Bogers S, Leijten LME, Laksono BM, Smeets LC, Bruning A, Benschop K, Wolthers K, van Riel D, GeurtsvanKessel CH. Detection of intrathecal antibodies to diagnose enterovirus infections of the central nervous system. J Clin Virol. 2022 Jul;152:105190. doi: 10.1016/j.jcv.2022.105190.
  • Bauer L, Laksono BM, de Vrij FMS, Kushner SA, Harschnitz O, van Riel D. The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2. Trends Neurosci. 2022 May;45(5):358-368. doi: 10.1016/j.tins.2022.02.006.

  • Sooksawasdi Na Ayudhya S, Laksono BM, van Riel D. The pathogenesis and virulence of enterovirus-D68 infection. Virulence. 2021 Dec;12(1):2060-2072. doi: 10.1080/21505594.2021.1960106.

  • Laksono BM, Tran DN, Kondova I, van Engelen HGH, Michels S, Nambulli S, de Vries RD, Duprex WP, Verjans GMGM, de Swart RL. Comparable Infection Level and Tropism of Measles Virus and Canine Distemper Virus in Organotypic Brain Slice Cultures Obtained from Natural Host Species. Viruses. 2021 Aug 10;13(8):1582. doi: 10.3390/v13081582.

  • Sooksawasdi Na Ayudhya S, Meijer A, Bauer L, Oude Munnink B, Embregts C, Leijten L, Siegers JY, Laksono BM, van Kuppeveld F, Kuiken T, Geurts-van Kessel C, van Riel D. Enhanced Enterovirus D68 Replication in Neuroblastoma Cells Is Associated with a Cell Culture-Adaptive Amino Acid Substitution in VP1. mSphere. 2020 Nov 4;5(6):e00941-20. doi: 10.1128/mSphere.00941-20. Erratum in: mSphere. 2020 Dec 9;5(6).

  • Rijsbergen LC, Rennick LJ, Laksono BM, van Run PRWA, Kuiken T, Duprex WP, de Swart RL, de Vries RD. In vivo comparison of a laboratory-adapted and clinical-isolate-based recombinant human respiratory syncytial virus. J Gen Virol. 2020 Oct;101(10):1037-1046. doi: 10.1099/jgv.0.001468.

  • Laksono BM, Fortugno P, Nijmeijer BM, de Vries RD, Cordisco S, Kuiken T, Geijtenbeek TBH, Duprex WP, Brancati F, de Swart RL. Measles skin rash: Infection of lymphoid and myeloid cells in the dermis precedes viral dissemination to the epidermis. PLoS Pathog. 2020 Oct 8;16(10):e1008253. doi: 10.1371/journal.ppat.1008253.
  • Geurts van Kessel CH, Okba NMA, Igloi Z, Bogers S, Embregts CWE, Laksono BM, Leijten L, Rokx C, Rijnders B, Rahamat-Langendoen J, van den Akker JPC, van Kampen JJA, van der Eijk AA, van Binnendijk RS, Haagmans B, Koopmans M. An evaluation of COVID-19 serological assays informs future diagnostics and exposure assessment. Nat Commun. 2020 Jul 6;11(1):3436. doi: 10.1038/s41467-020-17317-y.

  • Laksono BM, de Vries RD, Duprex WP, de Swart RL. Measles pathogenesis, immune suppression and animal models. Curr Opin Virol. 2020 Apr;41:31-37. doi: 10.1016/j.coviro.2020.03.002.

  • Petrova VN, Sawatsky B, Han AX, Laksono BM, Walz L, Parker E, Pieper K, Anderson CA, de Vries RD, Lanzavecchia A, Kellam P, von Messling V, de Swart RL, Russell CA. Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles. Sci Immunol. 2019 Nov 1;4(41):eaay6125. doi: 10.1126/sciimmunol.aay6125.

  • Smith SE, Busse DC, Binter S, Weston S, Diaz Soria C, Laksono BM, Clare S, Van Nieuwkoop S, Van den Hoogen BG, Clement M, Marsden M, Humphreys IR, Marsh M, de Swart RL, Wash RS, Tregoning JS, Kellam P. Interferon-Induced Transmembrane Protein 1 Restricts Replication of Viruses That Enter Cells via the Plasma Membrane. J Virol. 2019 Mar 5;93(6):e02003-18. doi: 10.1128/JVI.02003-18.

  • Laksono BM, de Vries RD, Verburgh RJ, Visser EG, de Jong A, Fraaij PLA, Ruijs WLM, Nieuwenhuijse DF, van den Ham HJ, Koopmans MPG, van Zelm MC, Osterhaus ADME, de Swart RL. Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands. Nat Commun. 2018 Nov 23;9(1):4944. doi: 10.1038/s41467-018-07515-0.

  • Laksono BM, Grosserichter-Wagener C, de Vries RD, Langeveld SAG, Brem MD, van Dongen JJM, Katsikis PD, Koopmans MPG, van Zelm MC, de Swart RL. In Vitro Measles Virus Infection of Human Lymphocyte Subsets Demonstrates High Susceptibility and Permissiveness of both Naive and Memory B Cells. J Virol. 2018 Mar 28;92(8):e00131-18. doi: 10.1128/JVI.00131-18.

  • Laksono BM, de Vries RD, McQuaid S, Duprex WP, de Swart RL. Measles Virus Host Invasion and Pathogenesis. Viruses. 2016 Jul 28;8(8):210. doi: 10.3390/v8080210.

  • van den Hoogen BG, van Boheemen S, de Rijck J, van Nieuwkoop S, Smith DJ, Laksono B, Gultyaev A, Osterhaus ADME, Fouchier RAM. Excessive production and extreme editing of human metapneumovirus defective interfering RNA is associated with type I IFN induction. J Gen Virol. 2014 Aug;95(Pt 8):1625-1633. doi: 10.1099/vir.0.066100-0.

  • Koel BF, van der Vliet S, Burke DF, Bestebroer TM, Bharoto EE, Yasa IW, Herliana I, Laksono BM, Xu K, Skepner E, Russell CA, Rimmelzwaan GF, Perez DR, Osterhaus AD, Smith DJ, Prajitno TY, Fouchier RA. Antigenic variation of clade 2.1 H5N1 virus is determined by a few amino acid substitutions immediately adjacent to the receptor binding site. mBio. 2014 Jun 10;5(3):e01070-14. doi: 10.1128/mBio.01070-14. Erratum in: MBio. 2014;5(4):doi:10.1128/mBio.01645-14.

Teaching activities

I have supervised Master’s students during their research internship and I participated in teaching and journal club supervision for the Infection and Immunity Master’s programme of Postgraduate School of Molecular Medicine, Erasmus MC.

Scholarships, grants, and awards

During my doctorate study, we had the unique opportunity to investigate measles immune suppression in unvaccinated children during measles outbreak in 2013. For this study, I received Best Publication Award in 2019 from the Postgraduate School of Molecular Medicine, Erasmus MC during 23rd Molecular Medicine Day.