Dr. D. A. J. (Debby) van Riel

Debby van Riel - Associate professor Department of Viroscience.

The RielScience team studies the systemic pathogenesis of respiratory virus infection. Although respiratory viruses cause in general mild disease, it is already known for decades that these infections can also result in severe systemic complication or extra-respiratory complication, such as CNS diseases. However, the pathogenesis of these diseases is poorly studied.

At this moment we study the systemic pathogenesis of influenza A viruses, Enterovirus D68 and SARS-CoV-2. These studies include:

1. How viruses can spread beyond the respiratory tract
2. How these viruses can trigger systemic inflammation
3. How these viruses can cause disease in tissues outside the respiratory tract (such as the central nervous system).
   
   

1. researchgate.
2. LinkedIn
3. twitter

 

 

Comparative pathology and Pathogenesis

Click here to view the publications of Debby van Riel

Recent Key publications:

1. The pathogenesis and virulence of enterovirus-D68 infection.
   Sooksawasdi Na Ayudhya S, Laksono BM, van Riel D.
   Virulence. 2021 Dec;12(1):2060-2072
   
   
2. Replication Kinetics, Cell Tropism, and Associated Immune Responses in SARS-CoV-2- and H5N1 Virus-Infected Human Induced Pluripotent Stem Cell-Derived Neural Models.
   Bauer L, Lendemeijer B, Leijten L, Embregts CWE, Rockx B, Kushner SA, de Vrij FMS, van Riel D.mSphere. 2021 Jun 30;6(3):e0027021
   
   
3. In Vivo Models to Study the Pathogenesis of Extra-Respiratory Complications of Influenza A Virus Infection.
   Veldhuis Kroeze E, Bauer L, Caliendo V, van Riel D.Viruses. 202
   
    
4. Temporal Kinetics of RNAemia and Associated Systemic Cytokines in Hospitalized COVID-19 Patients.
   van Riel D, Embregts CWE, Sips GJ, van den Akker JPC, Endeman H, van Nood E, Raadsen M, Bauer L, van Kampen J, Molenkamp R, Koopmans M, van de Vijver D, GeurtsvanKessel CH.mSphere. 2021 Jun 30;6(3):e0031121
   
   
5. A High-Fat Diet Increases Influenza A Virus-Associated Cardiovascular Damage.
   Siegers JY, Novakovic B, Hulme KD, Marshall RJ, Bloxham CJ, Thomas WG, Reichelt ME, Leijten L, van Run P, Knox K, Sokolowski KA, Tse BWC, Chew KY, Christ AN, Howe G, Bruxner TJC, Karolyi M, Pawelka E, Koch RM, Bellmann-Weiler R, Burkert F, Weiss G, Samanta RJ, Openshaw PJM, Bielefeldt-Ohmann H, van Riel D, Short KR.J Infect Dis. 2020 Aug 4;222(5):820-831
   
   
6. A Novel Coronavirus Emerging in China - Key Questions for Impact Assessment.
   Munster VJ, Koopmans M, van Doremalen N, van Riel D, de Wit E.N Engl J Med. 2020 Feb 20;382(8):692-694
   
   
7. Role of Endothelial Cells in the Pathogenesis of Influenza in Humans.
   Short KR, Kuiken T, Van Riel D.J Infect Dis. 2019 Oct 22;220(11):1859-1860
   
   
8. Viral Factors Important for Efficient Replication of Influenza A Viruses in Cells of the Central Nervous System.
   Siegers JY, van de Bildt MWG, Lin Z, Leijten LM, Lavrijssen RAM, Bestebroer T, Spronken MIJ, De Zeeuw CI, Gao Z, Schrauwen EJA, Kuiken T, van Riel D.J Virol. 2019 May 15;93(11):e02273-1
   
   
9. Mini viral RNAs act as innate immune agonists during influenza virus infection.
   Te Velthuis AJW, Long JC, Bauer DLV, Fan RLY, Yen HL, Sharps J, Siegers JY, Killip MJ, French H, Oliva-Martín MJ, Randall RE, de Wit E, van Riel D, Poon LLM, Fodor E.Nat Microbiol. 2018 Nov;3(11):1234-1242

Debby has received several grants and fellowships that support her research group, including a Veni, Erasmus MC fellowship, Vidi, EUR fellowship and Aspasia (total > 1.5 million Euro). In addition, Debby received the Beijerinck premium in 2015 (2 yearly award for promising early career scientists within virology research in the Netherlands), the ESWI Award in 2017 (3-yearly international awards for the most promising body of work in influenza virus research from European Scientific Working group on Influenza) and she is a member of the Young Erasmus Academy.

• Prof. Dr. Gülsah Gabriel, Heinrich-Pette Institute (HPI) Hamburg, GermanyDebby is employed as a guest scientist at the HPI. This collaboration is based on the joint interest in the pathogenesis of influenza virus infections. This collaboration resulted in several joint publications (Anfasa 2017; Betram 2017; van Riel 2016; Otte 2016 and Siegers 2014)
• Dr. Kirsty Short, Queensland University, Australia. The collaboration with Kirsty Short is based on our joint interest in extra-respiratory immune responses during influenza virus
  infections. This collaboration recently resulted in a joint publication in J Infect Dis (short 2017).
• Dr. Emmie de Wit, RML NIH, Montana US. The Collaboration with Dr de With is based on on our joint interest in the pathogenesis of 1918 H1N1 Influenza virus (Spanish flu)
  with a specific focus on extra-respiratory tract complications.

The RielScience team consists out of a diversity of amazing scientists from all over the world! 

Current members:

• Debby van Riel – Associate Professor
• Brigitta Laksono – Postdoc
• Lisa Bauer – Postdoc
• Jurre Siegers – PhD student
• Syriam Sooksawasdi Na Ayudhya – PhD student
• Feline Benavides – PhD student
• Lonneke Leijten – Research technician