Field(s) of expertise
- Immunological responses to respiratory viruses
- Pathogenesis of viral infections
- Paramyxoviruses, Pneumoviruses, Influenza viruses, Coronaviruses
- Primary models for virus-host interactions (animal models and primary cells)
Education and career
As a scientist I actively participate in the international field of immunology and infectious diseases as member of WHO working groups, ESPID, ESCMID, ESV, ASV and the Microbiology Society, presenting my work at conferences on average 5-10 times per year. Additionally, I hold several positions of trust; among others I am an editorial board member for the peer-reviewed journals “Frontiers in Immunology” and “Vaccines”, and am a frequent grant proposal and manuscript reviewer. I also actively teach young minds in multiple MSc programs in the Netherlands (e.g. ‘Infection & Immunity’ at the Erasmus MC). In addition to my research achievements, I enjoy sharing knowledge on immunology and infectious diseases to a broad audience. I am involved in the design and execution of the “Viruskenner” project since 2012, a project that generates awareness for viral infections and spread among high school students. Additionally, I participate in “Open Campus” and “March for Science” events, and give vaccination advice workshops to risk groups and individuals that refuse vaccination.
- Measles immune suppression: lessons from the macaque model.
R.D.de Vries, McQuaid S, van Amerongen G, Yüksel S, Verburgh RJ, Osterhaus AD, Duprex WP, de Swart RL. PLoS Pathog. 2012;8(8):e1002885.
- Induction of Cross-Clade Antibody and T-Cell Responses by a Modified Vaccinia Virus Ankara-Based Influenza A(H5N1) Vaccine in a Randomized Phase 1/2a Clinical Trial.
R.D.de Vries, Altenburg AF, Nieuwkoop NJ, de Bruin E, van Trierum SE, Pronk MR, Lamers MM, Richard M, Nieuwenhuijse DF, Koopmans MPG, Kreijtz JHCM, Fouchier RAM, Osterhaus ADME, Sutter G, Rimmelzwaan GF. J Infect Dis. 2018 Jul 13;218(4):614-623.
- Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome
.D. Weiskopf, K. S. Schmitz, M. P. Raadsen, A. Grifoni, N. M. A. Okba, H. Endeman, J. P. C. van den Akker, R. Molenkamp, M. P. G. Koopmans, E. C. M. van Gorp, B. L. Haagmans, R. L. de Swart, A. Sette, R.D. de Vries. Sci Immunol 5, (2020).
- SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccinees.
D. Geers, M. C. Shamier, S. Bogers, G. den Hartog, L. Gommers, N. N. Nieuwkoop, K. S. Schmitz, L. C. Rijsbergen, J. A. T. van Osch, E. Dijkhuizen, G. Smits, A. Comvalius, D. van Mourik, T. G. Caniels, M. J. van Gils, R. W. Sanders, B. B. Oude Munnink, R. Molenkamp, H. J. de Jager, B. L. Haagmans, R. L. de Swart, M. P. G. Koopmans, R. S. van Binnendijk, R.D. de Vries, C. H. GeurtsvanKessel. Sci Immunol 6, (2021).
- Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets.
R.D. de Vries, K. S. Schmitz, F. T. Bovier, C. Predella, J. Khao, D. Noack, B. L. Haagmans, S. Herfst, K. N. Stearns, J. Drew-Bear, S. Biswas, B. Rockx, G. McGill, N. V. Dorrello, S. H. Gellman, C. A. Alabi, R. L. de Swart, A. Moscona, M. Porotto. Science 371, 1379-1382 (2021).
- The immunogenicity, tolerability and safety of COVID-19 vaccination in patients with chronic kidney disease, on dialysis, or living with a kidney transplant.
J.F. Sanders, F.J. Bemelman, L. Messchendorp, C.C. Baan, D. van Baarle, R. van Binnendijk, D.A. Diavatopoulos, S.C. Frölke, D. Geers, C.H. GeurtsvanKessel, G. den Hartog, M. van der Heiden, C. Imhof, M.M.L. Kho, M.P.G. Koopmans, R.K. Malahe, W. B. Mattheussens, R. van der Molen, D. van Mourik, E.B.M. Remmerswaal, N. Rots, P. Vart, R.D. de Vries, R.T. Gansevoort, L.B. Hilbrands, M.E.J. Reinders, RECOVAC Collaborators. Transplantation (in press, 2021).
Contributions to books
- Measles virus: a respiratory virus causing systemic disease.
De Vries RD and RL de Swart. Book chapter, in: Human Respiratory Viral Infections. CRC Press, ISBN 9781466583207 (2014).
- Morbillivirus infection in non-human primates: from humans to monkeys and back again.
De Vries RD, Kuiken T and de Swart RL. Chapter 14 in: Neglected Diseases in Monkeys. L. Jones-Engel and S. Knauf, Eds. Springer, in pre Management
Rory has been teaching in two different Master programs: "Infection & Immunity" at Erasmus MC and "Molecular Life Sciences" at the Hogeschool of Arnhem and Nijmegen. Since 2014 Rory is a teacher in the LCR schooling program for vaccination physicians, teaching basic immunology and vaccinology. Since 2016, Rory is a teacher in the article 9 course at the Erasmus MC, instructing on experimental design of animal studies and handling of laboratory animals. Finally, he has supervised multiple Bachelor students, Master students, and currently supervises 5 PhD students.
Scholarships, grants, and awards
- Awarded membership of the ‘Vaccine’ Young Investigator Program (2016-2018)
- KNAW Beijerinck Premium
- Detection of specific and cross-reactive cellular responses to coronaviruses (Health Holland)
- COVID-19 vaccination programs: heterologous prime boost regimens, vaccination in primary immunodeficiencies, vaccination of kidney patients (ZonMw)
- Fusion inhibitors that block SARS-CoV-2 (NIH)
- Novel tools to support measles control and elimination (ZonMw)
Sociatal Impact of research
Rory is active as coach in the "Viruskenner" project. This project aims to help create more awareness about viral diseases and the way we can fight the transmission of these viruses among school-aged children. See: viruskenner
Impact of his PhD thesis:
Upon publication of his PhD thesis "Novel insights into measles pathogenesis and immune suppression" in 2013, the Netherlands was on the verge of a new measles epidemic. Therefore, shortly after publication of the thesis, the impact of this thesis on vaccination policy was widely discussed in the press, leading to multiple articles in national newspapers & interviews on radio and television. See e.g. the following examples:
- Mazelenvaccinatie werkt niet alleen goed tegen de mazelen maar ook tegen andere infecties
- Mazelen is geen onschuldige kinderziekte
- Mazelen rukken op in Europa
Impact of PostDoc research:
His PostDoc research focussed on the generation of novel influenza vaccines. With yearly influenza vaccinations and epidemics, he is frequently consulted by and cited in Dutch national newspapers and Dutch journals (i.e. Bioké among others) on the subject of novel "universal" influenza vaccines. See e.g. the following examples:
- Op zoek naar de heilige graal
- Vaccinproduktie kan sneller en beter
His current research focuses on the interaction between respiratory viruses (paramyxoviruses, pneumoviruses, coronaviruses) and the host immune system. In the ongoing COVID-19 pandemic, this specialty led to inclusion in major vaccinations studies in the Nehterlands, in healthy individuals, transplant recipients, and patients with immune deficiencies. He is frequently cited in Dutch newspapers and on television on the topic of SARS-CoV-2-specific imunity, e.g.:
- NRC, 26 May 2021: Ook t-cellen beschermen na vaccin tegen varianten
- Nu.nl, 22 January 2021: Gaat vaccineren onze natuur tegen?
- Hart van Rotterdam, afl. 3, 2 November 2021: