Field(s) of expertise
Rory showed that in a non-human primate model measles vaccination protected macaques from disease caused by distinct but related animal viruses, due to presence of cross-reactive T-cells. Taking this one step further, he identified measles virus-specific T-cells that recognize many other viruses within the same virus family - Paramyxoviridae. These cross-reactive T-cells recognize epitopes of paramyxoviruses that are highly genetically conserved owing to strong functional constraints that prevent mutations. This led him to start a Postdoctoral project to develop an innovative 'universal' influenza vaccine by genetically designing and optimizing viral proteins to induce influenza virus-specific cross-reactive antibodies and T-cells.
- Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands.
Laksono BM, de Vries RD, Verburgh RJ, Visser EG, de Jong A, Fraaij PLA, Ruijs WLM, Nieuwenhuijse DF, van den Ham HJ, Koopmans MPG, van Zelm MC, Osterhaus ADME, de Swart RL. Nat Commun (in press).
- Induction of Cross-Clade Antibody and T-Cell Responses by a Modified Vaccinia Virus Ankara-Based Influenza A(H5N1) Vaccine in a Randomized Phase 1/2a Clinical Trial.
de Vries RD, Altenburg AF, Nieuwkoop NJ, de Bruin E, van Trierum SE, Pronk MR, Lamers MM, Richard M, Nieuwenhuijse DF, Koopmans MPG, Kreijtz JHCM, Fouchier RAM, Osterhaus ADME, Sutter G, Rimmelzwaan GF. J Infect Dis. 2018 Jul 13;218(4):614-623.
- Modified Vaccinia Virus Ankara Preferentially Targets Antigen Presenting Cells In Vitro, Ex Vivo and In Vivo.
Altenburg, A.F., C.E. van de Sandt, B.W.S. Li, R.J. MacLoughlin, R.A.M. Fouchier, G. van Amerongen, A. Volz, R.W. Hendriks, R.L. de Swart, G. Sutter, G.F. Rimmelzwaan and R.D. de Vries. Sci Rep 7(1): 8580 (2017).
- Delineating morbillivirus entry, dissemination and airborne transmission by studying in vivo competition of multicolor canine distemper viruses in ferrets.
De Vries RD, Ludlow M, de Jong A, Rennick LJ, Verburgh RJ, van Amerongen G, van Riel D, van Run PRWA, Herfst S, Kuiken T, Fouchier RAM, Osterhaus ADME, de Swart RL* and Duprex WP*. PLoS Pathog. 8; 13(5): e1006371 (2017).
- Measles immune suppression: lessons from the macaque model.
de Vries RD, McQuaid S, van Amerongen G, Yüksel S, Verburgh RJ, Osterhaus AD, Duprex WP, de Swart RL. PLoS Pathog. 2012;8(8):e1002885.
- Early target cells of measles virus after aerosol infection of non-human primates.
Lemon K*, de Vries RD*, Mesman AW, McQuaid S, van Amerongen G, Yüksel S, Ludlow M, Rennick LJ, Kuiken T, Rima BK, Geijtenbeek TB, Osterhaus AD, Duprex WP, de Swart RL. PLoS Pathog. 2011 Jan 27;7(1):e1001263
Contributions to books
- Measles virus: a respiratory virus causing systemic disease.
De Vries RD and RL de Swart. Book chapter, in: Human Respiratory Viral Infections. CRC Press, ISBN 9781466583207 (2014).
- Morbillivirus infection in non-human primates: from humans to monkeys and back again.
De Vries RD, Kuiken T and de Swart RL. Chapter 14 in: Neglected Diseases in Monkeys. L. Jones-Engel and S. Knauf, Eds. Springer, in pre Management
Rory has been teaching in two different Master programs: "Infection & Immunity" at Erasmus MC and "Molecular Life Sciences" at the Hogeschool of Arnhem and Nijmegen.Since 2014 Rory is a teacher in the LCR schooling program for vaccination physicians, teaching basic immunology and vaccinology. Since 2016, Rory is a teacher in the article 9 course at the Erasmus MC, instructing on experimental design of animal studies and handling of laboratory animals. Finally, he has supervised multiple Bachelor and Master students.
As an experienced user of flow cytometers and confocal microscopes Rory trains novel users and students to make experimental designs and protocols for this technology. Furthermore, he gives introductory lectures on the use of flow cytometers and guide users through their first set of experiments. In addition, he is a supervisor of the animal laboratory at the Viroscience department of Erasmus MC and trains new users of this laboratory in basic handling of small laboratory animals.
During his time as PostDoc (2013-2018) Rory co-managed (together with the principal investigator and project office) the EU FP7 project InFLUenza virus UNIversal VACcine development program (FLUNIVAC).
Rory has been involved in the "Viruskenner" project since 2012, a project that focuses on generating awareness for viral infections and viral spread among high school students.
managing laboratory space and technology.
The flow cytometers within the Erasmus MC department of Viroscience, currently responsible for the animal laboratory within the same department making sure that all permits required to do experiments are in place (GMO and animal). He is the first line of response in the case of alarms generated by BSL3 isolators in the animal facility. Finally, he is responsible for drafting and managing mouse animal protools.
Scholarships, grants, and awards
• KNAW Beijerinck premie
Sociatal Impact of research
Rory is active as coach in the "Viruskenner" project. This project aims to help create more awareness about viral diseases and the way we can fight the transmission of these viruses among school-aged children. See: viruskenner
Impact of his PhD thesis:
Upon publication of his PhD thesis "Novel insights into measles pathogenesis and immune suppression" in 2013, the Netherlands was on the verge of a new measles epidemic. Therefore, shortly after publication of the thesis, the impact of this thesis on vaccination policy was widely discussed in the press, leading to multiple articles in national newspapers & interviews on radio and television. See e.g. the following examples:
- Mazelenvaccinatie werkt niet alleen goed tegen de mazelen maar ook tegen andere infecties
- Mazelen is geen onschuldige kinderziekte
- Mazelen rukken op in Europa
As his current research focuses on the generation of novel influenza vaccines, in combination with yearly influenza vaccinations and epidemics, he is frequently consulted by and cited in Dutch national newspapers and Dutch journals (i.e. Bioké among others) on the subject of novel "universal" influenza vaccines. See e.g. the following examples:
- Op zoek naar de heilige graal
- Vaccinproduktie kan sneller en beter