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erlenmyer-research
Research group/lab  |  PI T.J. van Ham, PhD

Macrophages in the healthy and diseased brain

Mutations in genes important for microglia, the brain’s macrophages, can predispose to brain diseases such as Alzheimer’s. The underlying mechanisms are largely unknown.

About our research group/lab

Our research

Background information

This group was formed to strengthen and expand research on functional genetics of disease, with the use of zebrafish. 

zebra fish 

Overall aim

We aim to understand how microglia function in the healthy brain and how gene mutations in microglia cause disease.

Understanding human disease genes in the zebrafish

Zebrafish are small and transparent in early embryonic development, but still share about 70% of genes with humans. Therefore they are very useful to help us understand how disease genes affect cells by visualizing cells directly in the context of a living animal. 

Research focus areas

Genetics and cell biology research using zebrafish as a model system with direct comparison to human post-mortem tissue.

Tissue

Key Publications

A complete overview of publications can be found here:

Our team

PI T.J. van Ham, PhD