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Research project

Congenital Melanocytic Nevi

Status: ongoing

Living with a (large) congenital melanocytic nevus (CMN) might imply a psychosocial burden both for the child and parents and may carry a higher risk of malignant melanoma.

What we do

About our project

Background information

Recent studies indicate a lower malignant risk of CMN than previously thought. As surgery has not been proven to lower that risk, the question is whether extensive surgery still benefits the patient. As a lager CMN needs several, often painful operations, which not always improve the cosmetics outcome and may even give unwanted aesthetic and functional results. In addition, the child is exposed to anesthetics large skin areas are treated. Unfortunately, reliable data on patient-important outcomes ( like aesthetics, functionality, patient satisfaction, treatment-related quality of life) and risks of treatment are lacking. 

Overall aim

Improving care for patients with congenital melanocytic nevi by developing standardized patient outcome measures.

Research method

By systematic literature searches, developing outcome measures together with patients with CMN and their parents, patient support groups and professionals nationally and internationally. 

Desirable outcome


Treating patients with a CMN in the Netherlands in the same way according to multidisciplinary guideline. This treatment is based and will be evaluated on outcomes that have been proven to be clinically relevant. 

  1. Guidline on CMN
  2. Laser therapy in CMN; systematic review
  3. Outcome of curettage therapy in CMN
  4. Outcome measures in CMN; systematic review
  5. Outcome measures (PROMs) in CMN


Landelijke Multidisciplinaire richtlijn congenitale nevi.

Zorg voor een kind geboren met een Giant Congenitale Melanocytaire Naevus (GCMN).

Incidence and relative survival of melanoma in children and adolescents in the Netherlands, 1989-2013.
Eggen CAM, Durgaram VVL, van Doorn R, Mooi WJ, Pardo LM, Pasmans SGMA, Hollestein LM. (2018). J Eur Acad Dermatol Venereol. 2018 Jun;32(6):956-961.

Laser treatment of congenital melanocytic naevi: a systematic review.
Eggen CAM, Lommerts JE, van Zuuren EJ, Limpens J, Pasmans SGMA, Wolkerstorfer A. (2018). Br J Dermatol. 2018 Feb;178(2):369-383.

Our team

  • Suzanne Pasmans, MD, PhD, dermatologist/immunologist, professor in pediatric dermatology: Principal investigator 
  • Ida Korfage, PhD epidemiologist, HTA,
  • Jolanda Okkerse, PhD, pediatric psychologist, project leader
  • Carsten Lincke, MD, PhD pediatrician rare diseases
  • Sarah Versnel. MD, PhD, plastic surgeon
  • Luba Pardo Cortes, MD epidemiologist, postdoc
  • Celine Eggen, MD, researcher
  • Elke Clout, MD student