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Principal Investigator

D.F. (Danielle) Majoor-Krakauer, MD

About

Introduction

Current research interest and goals

Delineating the genetics of common cardiovascular disorders, in particular abdominal aortic aneurysm and noncompaction cardiomyopathy, and use genetic information to predict risk for specific clinical features. The key to reduce disease burden is the early detection and timely treatment for high-risk populations, i.e. families, and attain personalized genotype driven clinical management and treatment options. 

Danielle Majoor trained in clinical genetics and in public health. She had performed large-scale studies which include clinical-, family- and genome (DNA) data, yielding novel genetic causes and molecular pathways and finding correlations between genotypes and clinical risks.

Field(s) of expertise

  • Clinical Genetics
  • Cardiovascular genetics
  • Aortic disease
  • Aneurysm
  • Familial aneurysm
  • Cardiovasular risk for relatives
  • Cardiovascular prevention
  • Aneurysm Screening
  • Cardiomyopathy
  • Hypermobility (HMS)
  • Ehlers Danlos Syndrome
  • Marfan Syndrome
  • Loeys Dietz syndrome
  • Vascular fragility

Education and career

  • Clinical Genetics, EMC since 1981.
  • MSC in Epidemiology, Sergievsky Center, Mailman School of Public Health,Columbia University, NY, NY USA.
  • PhD "Genetic epidemiology of Amyotrophic lateral Sclerosis", 2005 Columbia University/EMC.
  • PI research in Noncompaction Cardiomyopathy.
  • PI research in Abdominal Aorta Aneurysm.

Publications

Risk of abdominal aortic aneurysm (AAA) among male and female relatives of AAA patients. Koen M van de Luijtgaarden, Sanne E Hoeks, Frederico Bastos Gonçalves, Ellen V Rouwet, Tabita M Valentijn, Robert J Stolker, Hence JM Verhagen, Danielle Majoor-Krakauer. (2017). Vasc Med. 2017 Apr;22(2):112-118.

Genetics, Clinical Features, and Long-Term Outcome of Noncompaction Cardiomyopathy. Jaap I. van Waning, Kadir Caliskan, Yvonne M. Hoedemaekers, Karin Y. van Spaendonck-Zwarts, Annette F. Baas, S. Matthijs Boekholdt, Joost P. van Melle, MD,g Arco J. Teske, Folkert W. Asselbergs, Backx, Gideon J. du Marchie Sarvaas, Michiel Dalinghaus, k Johannes M.P.J. Breur, Marijke P.M. Linschoten, Laura A. Verlooij, Isabella Kardys, Dennis Dooijes, Ronald H. Lekanne Deprez, Arne S. IJpma, Maarten P. van den Berg, Robert M.W. Hofstra, Marjon A. van Slegtenhorst, Jan D.H. Jongbloed, Danielle Majoor-Krakauer. (2018). J Am Coll Cardiol. 2018;71(7):711–22.

Cardiac Phenotypes, Genetics, and Risks in Familial Noncompaction Cardiomyopathy. Van Waning JI, Caliskan K, Michels M, Schinkel AFL, Hirsch A, Dalinghaus M, Hoedemaekers YM, Wessels MW, IJpma AS, Hofstra RMW, van Slegtenhorst MA, Majoor-Krakauer D. (2019). J Am Coll Cardiol. 2019 Apr 9;73(13):1601-1611.

First genetic analysis of aneurysm genes in familial and sporadic abdominal aortic aneurysm. Van de Luijtgaarden KM, Heijsman D, Maugeri A, Weiss MM, Verhagen HJ, IJpma A, Brüggenwirth HT, Majoor-Krakauer D. (2015). Hum Genet. 2015 Aug;134(8):881-93.

Risk of abdominal aortic aneurysm (AAA) among male and female relatives of AAA patients. Van de Luijtgaarden KM, Rouwet EV, Hoeks SE, Stolker RJ, Verhagen HJ, Majoor-Krakauer D. (2017).Vasc Med. 2017 Apr;22(2):112-118.

The Importance of Genetic Counseling, DNA Diagnostics, and Cardiologic Family Screening in Left Ventricular Noncompaction Cardiomyopathy. Hoedemaekers YM, Caliskan K, Michels M, Frohn Mulder I, van der Smagt JJ, Phefferkorn JE, Wessels MW, ten Cate FJ, Sijbrands EJ, Dooijes D, Majoor-Krakauer DF. (2010). Circ Cardiovasc Genet. 2010 Jun;3(3):232-9.

A complete overview of publications can be found here

Teaching activities

Supervised Thesis

  • Yvonne M. Hoedemakers: "Genetic Aspects and family studies of noncomapction and hypertrophic cardiomyopathy" 2010 EMC.
  • Koen M, van de Luijtgaarden: "Familial abdominal aortic aneurysm" 2016 EMC.

Scholarships, grants, and awards

2012

  • Genetische research naar abdominale aorta genen (GRAAG).

2014

  • Genexpressie analyse ter detectie van de moleculaire mechanismen van aneurysmavorming (GAMMA).

2014

  • Geneitsch onderzoek naar noncomapctie cardiomyopathy.

2017

  • Study of biomarker profiling to unravel the intertwinded pathophysiology of coronary artery disease and abdominal aorta aneurysm (BIOMARCS-AAA).