Finding novel routes to penetrate the mycetoma grain (PENEGRAIN)
The tropical disease mycetoma can be caused by bacteria or fungi. Characteristic of this disease is the formation of a shield by the pathogens which protect them against drugs. This makes this disease untreatable. PENEGRAIN is an open science project in which scientists and laymen will collaborate to open up this shield. We will create novel models which we will use to determine how this shield is created and which drugs and carriers can penetrate. This research will lead to novel drugs which can be used not only for mycetoma but also for other difficult to treat infections.
Development of a point-of-care diagnostic test for mycetoma in Africa
The tropical disease mycetoma can be caused by bacteria or fungi. Characteristic of this disease is the formation of a shield by the pathogens which protect them against drugs. This makes this disease untreatable. PENEGRAIN is an open science project in which scientists and laymen will collaborate to open up this shield. We will create novel models which we will use to determine how this shield is created and which drugs and carriers can penetrate. This research will lead to novel drugs which can be used not only for mycetoma but also for other difficult to treat infections.
This research line focusses on the impact of rheumatic diseases on sexuality, fertility, pregnancy outcome and the development of children born to parents with a rheumatic disease.
