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Research project

EFFECTS - Echocardiographic Tissue Stiffness measurements

Status: Ongoing project, Start date: September 2016, End date: August 2021

EFFECTS delivers a technique for early diagnosis of heart failure by measuring the stiffening of the heart, through non-invasive ultrasound imaging.

What we do

About our project

Background information

Heart failure is a major public health problem in developed countries. There is a poor prognosis in patients with heart failure. Left ventricular diastolic dysfunction is one of the important underlying mechanisms, to a large extent caused by increased stiffness of the heart. Patients with predominantly diastolic dysfunction have a 1-year mortality rate of 25%. Currently, there is no accurate non-invasive method for early diagnosis of heart failure and there is no method of monitoring the therapy.

Overall aim

EFFECTS delivers a technique for early diagnosis of stiffening of the heart, which employs non-invasive ultrasound imaging. We use a very high frame rate (1000 FPS) acquisition system to capture the waves, on a clinical machine that was custom programmed for this project. The new method is based on the natural shear waves in the heart muscle, which find their origin in the natural "noise-like" mechanical excitations caused by the valve closure heart, atrial contraction, flowing blood, etc. The propagation velocity of the resulting natural shear waves is dependent on the local stiffness of the heart muscle.

Research method

The team consists of several researchers with their own specialism: data processing, imaging systems, and pre-clinical, voluntary, and clinical studies. From scratch, we will develop and test the concepts to accurately measure the stiffness.

Desirable outcome

We will test the system both in lab-settings and in patients, within and outside Erasmus MC to be able to show the benefit of the technique to recognize increased stiffness of the heart wall.

Funds & Grants

This work is part of the STW – Dutch Heart Foundation partnership program ‘Earlier recognition of cardiovascular diseases’ with project number 14740, which is (partly) financed by the Netherlands Organization for Scientific Research (NWO).

Collaborations

Publications

Our team

  • Rik Vos
  • Nico de Jong
  • Hans Bosch
  • Lana Keijzer
  • Mihai Strachinaru
  • Annette Caenen

Any questions or comments?

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