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erlenmyer-research
Research group/lab  |  Thoraxcenter

Biomedical Engineering

At the crossroads of physics, technology, biology and medicine, we develop technology for insights in cardiovascular disease, and to improve its diagnosis and treatment.

About our research group/lab

Our research

Background

At Biomedical Engineering, for over 50 years now, engineers, scientists, clinicians, and companies team up to address the challenging task of diagnosis, treatment, and monitoring of cardiovascular diseases. The group, part of the Cardiology department of Erasmus MC, forms a strong multidisciplinary team to develop novel diagnostic and treatment strategies. The work covers the entire pathway from basic concepts and modelling to laboratory work, patient studies, and commercialization. 

Overall aim

Imaging, modelling and data interpretation stand at the basis of disease diagnosis, treatment, therapy guidance and monitoring, such that clinicians can provide better prognosis for the patient. We aim to develop and study unprecedented techniques to image the cardiovascular system and improve treatment of the patient.

Research focus area

The body contains many dynamics, e.g. the heart motion and blood flow, but also biological interactions between cells and their environment. We study and predict these complex dynamics, through state-of-the-art (and beyond) high frame rate techniques, thus being able to show the phenomena in slow-motion. For this, we build and use volumetric transducers and systems for echography, camera systems for in vitro visualization, and advanced computer models to predict and analyze the physics and biology underlying the phenomena. We challenge ourselves to develop the imaging, understand and model the physics and biology, improve the signal processing, and interpret the results with clinicians to provide actual information needed for better treatment of patients.

Our four research themes

Our projects

Atherosclerosos Biomechanics

Biomechanics and Atherosclerosis

This research project studies the influence of biomechanical stress on the development, progression and rupture of atherosclerotic plaques.

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Biomechanics in Congenital Cardiology

We aim to unravel the etiology of cardiovascular complications in patients with congenital heart disease and to advance personalized treatment of these patients.

A microbubble

BUBBLE CURE

Targeted microbubble vibrations to accurately diagnose and treat cardiac device-related bacterial biofilm infections (ERC starting grant Kooiman)

BUBBLE QUEST

BUBBLE QUEST

Drug delivery through microbubbles: the quest for the missing link (VIDI Kooiman)

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Cardiac Mechanics

This multidisciplinary project is performed by a team of engineers and clinicians from the Departments of Biomedical Engineering, Cardiology, Pediatric Cardiology and Radiology.

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EFFECTS - Echocardiographic Tissue Stiffness measurements

EFFECTS delivers a technique for early diagnosis of heart failure by measuring the stiffening of the heart, through non-invasive ultrasound imaging.

human disease model for atherosclerosis

Human disease model for atherosclerosis

We tissue engineer human disease models for atherosclerosis to unravel the process of atherosclerotic plaque rupture and to identify new imaging biomarkers.

Imaging atherosclerotic plaque lipidomics in vivo

Imaging atherosclerotic plaque lipidomics in vivo

(Vici Van Soest)

Miffy

MIFFY- Monitoring infant brain perfusion by echography

MIFFY delivers a technique for early diagnosis of brain perfusion failure by measuring the flow, stiffness and anatomy with non-invasive ultrasound imaging.

Molecular Imaging of Atherosclerosis

Molecular imaging of atherosclerosis

We develop new diagnostic imaging, aimed at targeting inflammation and calcification with radionuclide imaging, to assess atherosclerotic plaque composition.

PARFAIT

PARFAIT

Photoacoustic imaging of Radiofrequency Ablation for Atrial Fibrillation Part of the NWO Perspectief consortium iMIT

QUANTO-3D-myocardial-perfusion-imaging-with-echography

QUANTO-3D-myocardial-perfusion-imaging-with-echography

This project focusses on new echography to measure the blood flow inside the heart wall, such that the interventions in the Cath lab can be better monitored.

Rapid Innovation of Minimally Invasive Instruments

Rapid Innovation of Minimally Invasive Instruments

This project is part of the Medical Delta and primarily is a collaboration between the MISIT group of the 3mE faculty at TU Delft, Surgery at LUMC, and the BME group of the Thorax Center at Erasmus MC.

Seeing the heart attack

Seeing the heart attack (and more) before it happens

I aim to develop new imaging technologies to visualize vulnerable plaques and other disease at early stage.

Petri dish

Sonobactericide to treat bacterial infective endocarditis

This project is using ultrasound and microbubbles for sonobactericde (Erasmus MC fellowship Kooiman)

Ultrasound scan

Theranostic-phospholipid-coated-ultrasound-contrast-agents

This project is developing novel phospolipid-coated microbubbles, i.e. ultrasound contrast agents, for ultrasound molecular imaging and drug delivery.

Key Publications

Collaborations

Collaboration within Erasmus MC

Collaborations outside Erasmus MC

We work within several local, national and international frameworks:

Within Biomedical Engineering, we are organizing 3 international annual conferences:

  • The International Symposium on Biomechanics in Vascular Biology and Cardiovascular Disease
  • Optics in Cardiology
  • The European symposium on Ultrasound Contrast Imaging and therapy

Funding & Grants

The group is well-funded with grants from many sources.

These include Open Technology projects and personal grants from the Dutch Research Council (NWO), public-private partnership grants such as the Medical Delta and a NWO/Dutch Heart Foundation grant, Open and Personal grants from the European Research Council, and many local initiatives such as the TU Delft/Erasmus MC Convergence, and the Erasmus MC fellowship. See specific pages per subgroup.

The group hosts a NWO PIONIER, A Simon Stevin Master, 2 ERC laureates, 3 Veni’s, 3 Vidi’s, 1 Vici and a marie curie fellow.  

Career opportunities

Available Bachelor/Master projects

Project: Analysis of 3D right ventricular shape from echocardiography 

Introduction

The functioning of our hearts is of vital importance to physical wellbeing. The right half of the heart is responsible for collecting the returning blood from the main circulation and pumping it to the lungs, where it is resupplied with oxygen. When the functioning of the right ventricle is compromised, venous pressure will rise and lung function will be decreased, leading to severe health problems on the long term.
The right ventricle has a complex 3D shape, similar to a thick triangle that is wrapped around the ellipsoidal left ventricle. It consists of an inlet zone, a main (apical) part and an outflow tract. It contracts in a complex peristaltic manner. For diagnosis of right ventricular function, 3D cardiac ultrasound can be used. We have collected about 200 4D (3D+time) echocardiography studies of the right ventricle in various congenital heart disease patient groups as well as healthy controls. These studies have already been semiautomatically analysed using Tomtec 4DRV software. We would like to perform further analyses on this large collection of 3D+T geometrical shapes of the right ventricle, such as local curvature, different decompositions of shape change, right ventricular global motion and local deformation. We want to relate those to patient characteristics. MRI analyses are available on part of the patients as well.

Purpose of this project

Implementation of several shape analyses of the right ventricle. Basic code for reading the shape files and original image files and visualizing them is available. Depending on the skills and technical and clinical interest of the candidate, the assignment can be limited or extended to include more complex spatiotemporal shape analyses, statistical analyses of the results, visualization/comparison tools etc. 

Short outline of the project (6-9 months)
  • Literature study on existing RV shape analyses
  • Design, implementation and testing of shape analysis methods
  • Generation of results on total data set
  • Optional: writing of publication, implementation of additional methods 
Requirements
  • Bachelor or master students Biomedical Engineering, Informatics, Clinical Technology or similar
  • Interest in medical imaging, biomedical research
  • Programming experience in MatLab, Python or C
For more information, please contact:
 

Project: Volumetric photoacoustic imaging of kidney

Introduction

Photoacoustics (PA) is a rapidly developing imaging modality which provides information about the molecular composition of biological tissue. The photoacoustic signal is generated by so-called chromophores, such as biological molecules that absorb light, which can transform absorbed light into an ultrasound signal. The presence of certain types of chromophores can be a valuable marker indicating the condition of biological tissue. The accurate quantification of certain types of chromophores can improve clinical diagnosis. 

However, at each moment, only a limited area of human tissue can be exposed by a light (laser) which impedes volumetric analysis of present chromophores. The goal of this project is to quantify present chromophores in large organs, e. g. kidney, which are normally challenging to be fully imaged with PA.

Clinical problem description

The main application of this project is kidney evaluation before transplantation . Only functioning and free of injuries kidney are suitable for transplantation. First, the kidney will be inspected for presence of injuries like necrosis or fibrosis. Second, the functioning of the kidney will be evaluated by measuring blood perfusion through the kidney’s cortex.

Technical problem description

We are using the pre-clinical Vevo LAZR-X photoacoustic system (Fujifilm Visual Sonics, Toronto, Canada). It comprises a laser source in a combination with high-frequency US probe. The probe is mounted in a translational stage facilitating 3D acquisition which volume is much smaller than the volume of the kidney.
Your task would be to develop a method for full volumetric reconstruction of the kidney based on small acquired sub-volumes. 

You will:
  • Get experience in PA and US imaging
    • Principles of PA imaging
    • Basics of B-mode US
    • PA spectroscopy
  • Solve a clinically relevant problem
Requirements
  • Confident user of Matlab or Python
  • Understanding of medical imaging
  • Being ready to read, write and code =)
For more information, please contact:

Our team

Principal Investigators

Postdocs

Phd Students