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research-project
Research project  |  Global Noronet

Noronet

Status: Ongoing

Noronet is a global network of scientists working in public health institutes or universities sharing virological, epidemiological and molecular data on norovirus.

What we do

About our project

Database

The shared database is password protected and accessible via the Internet for data entry, sharing and analysis. Online analysis tools are available:
- Incidence plots
- Pie charts
- Phylogenetic tree tool
- Geographical plot

he Noronet database can be accessed here.

Typing tool

In order to ensure standardized typing of the sequences, all submitted sequences are typed using the publicly accessible norovirus typing tool on the website of the RIVM.

Examples of what we do and newletters that you receive as a member

Below you can find an overview of the polymerase and capsid genotypes that members have reported to NoroNet for genogroup I (GI) and II (GII) from January 2015 until June 2018. Figures 1 to 7 show the data for the polymerase and capsid genotypes per year and per country. For GI we see co-circulation of several capsid and polymerase genotypes (Figure 1, Figure 5 and 7).

 

vp1 genogroup 1

Figure 1 GI Polymerase and Capsid genotypes per year

For GII the most prevalent polymerase genotypes are GII.P4 Orleans 2009, GII.Pe, GII.P17 and GII.P16 (Figure 2, Figure 6). The polymerase GII.P16 has circulated for years with different capsid genotypes, but in the past years it became the predominant polymerase genotype and is mostly found in combination with the capsid genotypes GII.4 Sydney 2012 and GII.2 (Table 1.).

Although there are many GII capsid genotypes co-circulating there are large differences in prevalence. GII.4 variant GII.4 Sydney 2012 is still the most prevalent genotype (Figure 3, Figure 4 and Figure 7). For  GII.17 there was a major increase in prevalence in 2015 and 2016, currently GII.17 outbreaks are still reported but at a lower frequency. For GII.2 there is also an increase in prevalence, mainly of GII.2 in combination with the GII.P16 genotype (Table 1).

Norornet Figure 2 Polymerase GII genotypes per year  

Figure 2 Polymerase GII genotypes per year

 

 

fig 2Polymerase GII genotypes per year

Figure 3 GII Capsid genotypes per year

 

Figure 4 GII.4 variants, capsid and polymerases

Figure 4 GII.4 variants, capsid and polymerases. *For GII.P16 all sequences were included including GII.P16 sequences that were detected in combination with a non-GII.4.

 

Figure 5. GI polymerase genotypes per country (>10 submitted sequences)

Figure 5. GI polymerase genotypes per country (>10 submitted sequences)

 

Figure 6. GII polymerase genotypes per country (>10 submitted sequences)

Figure 6. GII polymerase genotypes per country (>10 submitted sequences)

 

 

 

Our research focus

The aim of Noronet is to enlarge the knowledge on geographical and temporal trends in the emergence and spread of Norovirus variants, thus limiting the impact and scale of future norovirus epidemics. A second aim is the design of a well founded standardized nomenclature for existing and emerging norovirus genotypes and variants or sub-lineages. By prospectively sharing information on norovirus activity we can chart the global spread, recognize changes in circulating strains and possible changes in the epidemiology of the virus and thus potentially predict epidemic seasons.

Want to know more about the NoreoNet?

Contact Prof. Marion Koopmans: contact

Or visit www.noronet.nl

 

 

Collaborations

Members Global Noronet

Noronet has members in Australia, Austria, Belgium, Canada, Chile, China, Denmark, Finland, France, Germany, Hong Kong, Hungary, Ireland, Italy, Japan, Netherlands, New Zealand, Norway, Russia, Slovenia, South Africa, Spain, Sweden, United States and the United Kingdom

Publications

Our team