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S.T.W. (Sofie) Jacobse

PhD Student

  • Department
  • General Practice
  • Focus area
  • Shared decision-making in the diagnostic phase of medical consultations



In September 2021 Sofie Jacobse started at the department as a PhD student. In 2022 she will combine her research with a residency in General Practice (aiotho).
Her research focuses on shared decision-making in the diagnostic phase of medical consultations. The aim is to develop evidence based educational material for the GP vocational training.

Sofie obtained her medical degree at the VU Medical Center in Amsterdam in 2017.
She worked for 3 years as a physician at several departments: pediatrics (Flevoziekenhuis and Jeroen Bosch Ziekenhuis), obstetrics and gynecology (Antonius Ziekenhuis) and psychiatry (Arkin). Additionally, she worked as a junior researcher at the department of pediatric oncology (Amsterdam University Medical center, location VUmc).


Jacobse STW*, van Kooten JAMC*, Heymans MW, de Vries R, Kaspers GJL, van Litsenburg RRL. A meta-analysis of accelerometer sleep outcomes in healthy children based on the Sadeh algorithm: the influence of child and device characteristics. Sleep. 2021 Apr 9;44(4):zsaa231.
* Both authors contributed equally tot his publication

Link to publications: Use link from Research gate or LinkedIn.
Sofie Jacobse | Researchgate.net
Sofie Jacobse | LinkedIn

Sofie is currently involved in the research project 'Shared decision making in diagnostic decisions: developing clinical based education to improve shared decision-making in the general practitioners’ vocational training'.

Recent Findings 

Previous studies in the lab have shown that autologous dendritic cells pulsed with allogenic tumor cell lysate was able to induce peripheral T cell activation and tumor-reactive T cell responses in patients with mesothelioma and pancreatic cancer. Current research focuses on how to initiate an effective immune response in the tumor as well as the tumor-draining lymph node using dendritic cell vaccination. Furthermore, we are studying novel approaches for (personalized) vaccination. In addition, we have identified T cell characteristics that underlie clinical efficacy of immune check inhibitors or chemotherapeutic agents in mesothelioma. The selected publications below give an impression of our work. 

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