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Principal Investigator

Dr. A.E. (Anouk) Muller, MD, PhD

  • Department
  • Medical Microbiology & Infectious Diseases
  • Focus area
  • Pharmacokinetics and pharmacodynamics of antibiotics



Anouk’s work involves several facets of the pharmacokinetic (PK) and pharmacodynamic (PD) research of antibiotics. To start with, work is being done to determine the PK / PD index. This is necessary to dose antibiotics in an optimal way. In addition, research is being conducted into how antibiotics behave in different patient groups. In addition to healthy volunteers, intensive care patients or patients with obesity are also being examined. Based on a mathematical model, predictions can be made on the amount of antibiotics needed for optimal treatment in these patients. This is crucial for advice on the dosage of the various antibiotics. In this research there is extensive collaboration with the hospital pharmacy, the intensive care unit, but also with other departments and research groups outside the Erasmus MC. The ultimate goal of this research area is to optimize antimicrobial therapy. 

Field(s) of expertise

  • Pharmacokinetic and Pharmacodynamic modelling
  • Susceptibility testing (microbiology)
  • Therapeutic Drug Monitoring

Education and career

Anouk studied medicine at the Leiden University Medical Centre. Afterwards she started her PhD research on the pharmacokinetics of several antibiotics during late pregnancy and delivery at the Haaglanden Medical Centre in The Hague and obtained her PhD in 2009 in Leiden. She was trained as clinical microbiologist in the Erasmus MC in Rotterdam, which she finished in 2012. She initially worked as clinical microbiologist in the Elisabeth-Twee Steden Hospital in Tilburg combined with research activities in the Radboud University in Nijmegen. Currently she is employed as clinical microbiologist at Haaglanden Medical Centre in The Hague and in the Erasmus MC for research activities. 


Publications of Anouk Muller can be found at ResearchGate

Teaching activities

Ongoing thesis supervision:

  • Eveline Roelofsen, Pharmacokinetics of beta-lactams, start 01-04-2019
  • Alan Abdulla, to TDM or not to TDM of beta-lactams, start 01-01-2018
  • Tim Ewoldt: to TDM or not to TDM of beta-lactams, start 01-04-2019
  • Wouter van der Bijllaardt: rapid susceptibility testing.

Anouk teaches during a national PK/PD course.