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Gijs van Nierop
Principal Investigator

Dr. G. P. (Gijsbert) van Nierop


Workgroup leader of the B-cell platform

  • Department
  • virology, Adaptive immunity



Current research interests and goal

With the B-cell platform at the department of Viroscience, Gijs studies the humoral antiviral immune response at the clonal level. Key interest is the immunological and clinical implication of pre-existing cross-reactive antibodies on viral infection. Priority viruses currently under investigation are flaviviruses, coronaviruses and influenza. The goal is to gain insight in what and how specific antibodies contribute to immune protection and pathogenesis.

Previous work and professional development

Gijs got his PhD on studying local humoral and cellular antiviral and auto-immune responses in multiple sclerosis patients under the supervision of prof.dr. RQ Hintzen and dr. GMGM Verjans. Here he developed a keen interest in immunopathology that may arise during the virus-host standoff. In his final year of PhD, he redirected the acquired expertise by developing an independent research line. He setup a B-cell platform that enables studying the breadth and magnitude of pre-existing and new humoral immune responses towards viral infections at the clonal level. He extended on this work by establishing a workgroup that is embedded in the exotic virus workgroup led by dr. B. H. G. Rockx.

External profile pages:




Education and career

Gijs received his PhD at the department of Neurology in 2018 for his multidisciplinary studies on the immunopathology that is associated with multiple sclerosis (MS). Here, he analyzed the presence of MS-associated viruses, the breadth and magnitude of the cellular and humoral antiviral and auto-immune responses in the context of MS-associated genetic risk profiles.


Key publications

Severe COVID-19 patients display a back boost of seasonal coronavirus-specific antibodies. Westerhuis BM, Aguilar-Bretones M, Raadsen MP, de Bruin E, Okba NMA, Haagmans BL, Langerak T, Endeman H, van den Akker JPC, Gommers DAMPJ, van Gorp ECM, Rockx BHG, Koopmans MPG, van Nierop GP. medRxiv 2020.10.10.20210070

Controverse omtrent denguevaccinatie. van Nierop GP, Martina BEE, Rockx BHG, Koopmans MPG. Ned Tijdschr Med Microbiol 2020;28(1):7-13

Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients. van Nierop GP, van Luijn MM, Michels SS, Melief MJ, Janssen M, Langerak AW, Ouwendijk WJD, Hintzen RQ, Verjans GMGM. Acta Neuropathol. 2017;134(3):383-401

Intrathecal CD4(+) and CD8(+) T-cell responses to endogenously synthesized candidate disease-associated human autoantigens in multiple sclerosis patients. van Nierop GP, Janssen M, Mitterreiter JG, van de Vijver DA, de Swart RL, Haagmans BL, Verjans GM, Hintzen RQ.
Eur J Immunol. 2016;46(2):347-53

Intrathecal CD8 T-cells of multiple sclerosis patients recognize lytic Epstein-Barr virus proteins. van Nierop GP, Mautner J, Mitterreiter JG, Hintzen RQ, Verjans GM.
Mult Scler. 2016;22(3):279-91

For a full overview see: https://pubmed.ncbi.nlm.nih.gov/?term=van+Nierop+GP&sort=pubdate

Teaching activities

  • Co-core teacher of the Infections and Immunity research master of the Molecular Medicine school
  • Co-promotor of Muriel Aguilar-Bretones MSc, a PhD student on arbovirus immunity.

Current research projects

One Health Pact




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