About Helen Ray-Jones, PhD
Introduction
In my research I try to interpret the role of genetic variants that influence a person’s underlying susceptibility to one or more complex diseases.
The majority of disease-associated variants do not fall within protein coding sequences, but instead lie within gene regulatory elements of the genome. These regulatory elements play a crucial role in ensuring the proper level of gene activity in each cell. Therefore, changes in the genetic code within these regions can greatly impact gene expression and downstream biological pathways, potentially leading to disease.
By combining genetic information with various epigenomics data types, including the “3D genome”, which enables regulatory elements to come into close proximity with gene transcription start sites over large genomic distances, I aim to pinpoint causal genetic variants and their associated genes. These genes are potential candidates for new therapeutic strategies.
Aside from this research, I am part of a small team here at Erasmus coordinating a large-scale initiative to build a reference dataset of whole genome sequences across European countries. I also participate in an international project that trials the incorporation of genomic information into standard healthcare practice.
Field(s) of expertise
Population genetics, gene regulation, chromatin, 3D genome, molecular biology, immunology, neuroscience.
Education and career
Bachelor of science with Honours (Biology)
PhD in Medicine (Inflammation and repair)
Postdoc positions in the UK and Belgium
