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Research group/lab  |  P.I. Professor dr. André Uitterlinden

Genetic Laboratory of Internal Medicine / Population Genomics

Our mission is to understand the genetics and genomics of complex traits and common diseases and apply the discoveries to clinical practice.

About our research group/lab

Our research

Research activities within the Genetic Laboratory of Internal Medicine / Population Genomics focus on genetics and genomics of complex traits and common diseases and are assigned to six research lines. Our research group is closely connected to the Human Genomics Facilitywhich provides services to internal and external customers.

Complex Diseases
(Professor dr. André Uitterlinden)

We study genetics and genomics of several common complex diseases and their risk factors, including endocrine and reproductive traits, and more in general ageing. We focus on bringing discoveries and genomic technology into the clinic.

Population Genomics of Locomotor Diseases and Ageing 
(Dr. Joyce van Meurs, UHD)

We study population genomics of age-related diseases, with a special focus on osteoarthritis and chronic pain. Focus is also on integrative genomics in population cohorts where multiple genomic levels are combined to understand and predict disease.

Translational Skeletal Genomics
(Professor dr. Fernando Rivadeneira)

We study the determinants of skeletal diseases along the life-course (with special focus on osteoporosis), seeking the translation of genomic discoveries into clinical applications. We do this by applying state-of-the art “big data” analytics integrating genomic functional assessments, imaging and other forms of medical data. 

Mendelian Genetics
(Dr. Annemieke Verkerk, UD)

We study monogenetic disease with Mendelian transmission and the population genetic context of pathogenic variations in disease genes. 

Microbiome Genomics
(Dr. Robert Kraaij, UD)

We study the microbial organisms in and on our body with next generation sequencing techniques, both in large cohort studies as well as in clinical settings. 

Complex and Rare Bone Disorders
(Professor dr. Carola Zillikens)

We study the mechanisms of complex and rare bone disorders, aiming to find novel therapeutic targets for treatments of disurbances in bone and mineral homeoatasis.

Our projects

Complex Diseases 
(Professor dr. André Uitterlinden)

GOALL In 2019 the Board of Directors endorsed this Genotyping on ALL patients (GOALL) project as a strategic goal within Erasmus MC. The project delivers tools, pipelines, and structures for using genetic information in the clinic such as polygenetic risk scores, Mendelian mutation panels, and pharmacogenetics. (Koers 23)

 

Population Genomics of Locomotor Diseases and Ageing 
(Dr. Joyce van Meurs, UHD)

VOILA. Vitality oriented lnnovation for the Lífecourse of the Ageing society (ZonMW)

FOCUM. (Reumafonds)

The interplay between MGP and VitK in the ethiology of osteoarthritis. We have recently identified MGP to be involved in osteoarthritis through a genome-wide association study. This project aims to elucidate how decreased function of MGP/ VitK affects cartilage/bone homeostasis and confers risk to osteoarthritis.(Reumafonds) 2017-2020

IFEROA. ldentification of the female specific etiology and risk groups for osteoarthritis (ZonMW-GENDER) 2017-2020

 

Translational Skeletal Genomics
(Professor dr. Fernando Rivadeneira)

GEMSTONE Genomics of Musculoskeletal Traits Translational Network - The project brings together a large international network of multidisciplinary experts seeking to translate genomic discoveries to the clinic.  (EU COST Action)

FIDELIO. Training network for research into bone Fragility In Diabetes across Europe: towards a personalized medicine approach (FIDELIO); one work package and two of the 12 ITN projects are coordinated by our group with special focus on genomic and gut microbiome research. (EU MARIE SKŁODOWSKA-CURIE ITN)

 

Mendelian Genetics
(Dr. Annemieke Verkerk, UD)

Genetics of Lungfibrosis. (Coolsingelstichting;  with dr. Leonie Vergouw)

Atypical Femur Fractures. (NHMRC Australia; with professor dr. Carola Zillikens

Microbiome Genomics
(Dr. Robert Kraaij, UD)

Gut microbiome in dementia. (ZonMW-Memorabel)

Mrace MOVE. (Erasmus MC grant; with professor dr. Greet Vos)

Complex and Rare Bone Disorders
(Professor dr. Carola Zillikens)

Key Publications

We publish extensively in major scientific journals, mainly through our international collaborations in consortia which result in highly cited papers. Please see  publications in the profiles of our researchers.

Dissertations

Students who obtained their PhD degree in our group:


 Sadaf oliai araghi_cover

Micronutrients and Health in Older Population: Friend or Foe?
S. (Sadaf) Oliai Araghi, March 2021
Promotor: A.G. (André) Uitterlinden / B.H.C. (Bruno) Stricker
Copromotor: J.C. Kiefte-de Jong / N. (Nathalie) van der Velde


Cindy Boer_cover

Osteoarthritis: genetics and phenotypes in all their complexity
C. (Cindy) Boer, Dec 2020
Promotor: A.G. (André) Uitterlinden
Copromotor: J.B.J. (Joyce) van Meurs


Jeroen van Rooij_cover

Sequencing, from blood to brain
J.G.J. (Jeroen) van Rooij, 
Dec 2020
Promotor: A.G. (André) Uitterlinden / 
J.C. (John) van Swieten
Copromotor: J.B.J. (Joyce) van Meurs


Katerina Trojanoska_cover

The interplay of bone and muscle in health and disease
K. (Katerina) Trajanoska,Oct 2020
Promotor: F. (Fernando) Rivadeneira
Copromotor: M.C. (Carolina) Medina Gomez


Natalia Campos Obando cover

Bone and Phosphate in Relation to Health, Survival and Genetic Factors
N. (Natalia) Campos Obando, May 2020
Promotor: A.G. (André) Uitterlinden / M.C. (Carola) Zillikens


Pooja Mandaviya cover

Effects of Methyl-group metabolism and lifestyle factors on genome-wide DNA methylation
P.R. (Pooja) Mandaviya, June 2018
Promotor: A.G. (André) Uitterlinden / J. (Jan) Lindemans
Copromotor:  J.B.J. (Joyce) van Meurs / S.G. (Sandra) Heil


Annelies Ham_cover

Medication use, falls and genetic variants in an older population
A.C. (Annelies) Ham, June 2017
Promotor: A.G. (André) Uitterlinden / B.H.C. (Bruno) Stricker
Copromotor: N. (Nathalie) van der Velde


Ester de Jonge_cover

What to eat for healthy bones? Epidemiological studies on diet, bone, health and frailty
E.A.L. (Ester) de Jonge, Dec 2016
Promotor: O.H. (Oscar) Franco / A.G. (André) Uitterlinden
Copromotor: F. (Fernando) Rivadeneira / J.C. Kiefte-de Jong


Carolona Medina-Gomez_cover

Disentangling the heterogeneity of bone accrual
M.C. (Carolina) Medina Gomez, May 2016
Promotor: A.G. (André) Uitterlinden
Copromotor: F. (Fernando) Rivadeneira


Marjolein de Kruijf_cover

A journey full of pain through the general population
M. (Marjolein) de Kruijf, April 2016
Promotor: A.G. (André) Uitterlinden / F.J.P.M. Huygen
Copromotor: J.B.J. (Joyce) van Meurs


Marjolein Peters

Integrating genomic approaches to understand ageing
M. J. (Marjolein) Peters, March 2016
Promotor: A.G. (André) Uitterlinden
Copromotor: J.B.J. (Joyce) van Meurs


Ling Oei_cover

Epidemiological, Radiological and Genetic Aspects of Endocrine Bone Diseases
L. (Ling) Oei, Dec 2016
Promotor: A.G. (André) Uitterlinden
Copromotor: F. (Fernando) Rivadeneira


Martha Castano Betancour_cover

Hip osteoarthritis: genetics, epiemiological risk factors and burden of the disease
M.C. (Martha) Castaño Betancourt, March 2015
Promotor: A.G. (André) Uitterlinden
Copromotor: J.B.J. (Joyce) van Meurs


Anke Enneman_cover

The role of homocysteine in bone
A. (Anke) Enneman, Nov 2014
Promotor: A.G. (André) Uitterlinden
Copromotor: M.C. (Carola) Zillikens


Yvonne Louwers_cover

Polysystic ovary syndrome: from phenotype to genotype
Y.V. (Yvonne) Louwers, Febr 2014
Promotor: J.S.E. (Joop) Laven / A.G. (André) Uitterlinden
Copromotor: L. (Lisette) Stolk


Eline Rodenburg_cover

Sex differences in cardiovascular drug response
E.M. (Eline) rodenburg
Promotor: B.H.Ch. (Bruno) Stricker / A.G. (André) Uitterlinden
Copromotor: L.E. Visser


Dissection of the complex genetic architecture of human stature and osteoporosis
K. (Karol) Estrada, June 2012
Promotor: A.G. (André) Uitterlinden
Copromotor: F. (Fernando) Rivadeneira


Hanneke Kerkhof_cover

Genetics of osteoarthritis: what a pain!
J.M. (Hanneke) Kerkhof, March 2012
Promotor: A.G. (André) Uitterlinden
Copromotor: J.B.J. (Joyce) van Meurs


Lisette Stolk_cover

Genetics of estrogen-related traits; from candidate genes to GWAS
L. (Lisette) Stolk, Dec 2009
Promotor: A.G. (André) Uitterlinden
Copromotor: J.B.J. (Joyce) van Meurs


Carola Zillikens_cover
The interplay of genes and diet in metabolic diseases and aging: studies on obesity, osteoporosis and survival
M.C. (Carola) Zillikens, Oct 2009
Promotor: A.G. (André) Uitterlinden / B.A. (Ben) Oostra / C.M. (Cock) van Duijn

 

Collaborations

Collaboration within Erasmus MC

We have strong historic ties with the department of Epidemiology, in the creation and conduction of the Rotterdam Study of elderly and the Generation R birth cohort, Erasmus MC Research Core Facilities). Furthermore, we closely collaborate with the departments of Clinical Genetics, Clinical Chemistry, Orthopedics, Radiology and Oral & Maxillofacial Surgery.

 

Collaboration outside of Erasmus MC

Most of our work takes place in large international consortia of collaborating investigators, several of which we have initiated ourselves (e.g., GEFOS, CHARGE, ReproGen, GO; see links below)

Funding & Grants

Complex Diseases 
(Professor dr. André Uitterlinden)

Koers 23

Population Genomics of Locomotor Diseases and Ageing 
(Dr. Joyce van Meurs, UHD)

Reumafonds

ZonMW-GENDER

ZonMW

Reumafonds

Translational Skeletal Genomics
(Professor dr. Fernando Rivadeneira)

EU COST Action

EU MARIE SKŁODOWSKA-CURIE ITN

Mendelian Genetics
(Dr. Annemieke Verkerk, UD)

Coolsingelstichting;  with dr. Leonie Vergouw

(NHMRC Australia; with professor dr. Carola Zillikens

Microbiome Genomics
(Dr. Robert Kraaij, UD)

ZonMW-Memorabel

Erasmus MC grant; with professor dr. Greet Vos

Complex and Rare Bone Disorders
(Professor dr. Carola Zillikens)

 

 

Career opportunities

Our group offers career opportunities for talented genomics researchers.  In addition we offer internships at academic and non-academic levels. Please inquire for vacancies or possibilities (e.vanveen@erasmusmc.nl).

 

Our team

Principal Investigators:

Profile picture of André UiterlindenProf. dr. André Uitterlinden

Profile picture of Joyce van MeursProf. dr. Joyce van Meurs

Prof. dr. Fernando Rivadeneira

Profile picture of Annemieke VerkerkDr. Annemieke Verkerk

Profile picture of Robert KraaijDr. Robert Kraaij

Profile picture of Carola ZillikensProf. dr. Carola Zillikens

Support:

Veen-Eline-vanEline van Veen (Secretariat)

Verkerk-Marijn_ITMarijn Verkerk (IT support)

Postdocs:

Profile picture of Carolina Medina-GomezDr. Carolina Medina Gomez

Dr. Linda Broer

Boer-CindyDr. Cindy Boer

Dr. Jeroen van Rooij

Dr. Ling Oei

Dr. Leonie Vergouw

 

PhD students are listed under the different PI's:

Prof dr. Joyce van Meurs

Arjan Bergink

Bahar Sedaghati Khayat 

Profile picture of Ingrid SzilagyiIngrid Kennis-Szilagyi

Lieke Kuiper

Yahong Wu


Prof. dr. Fernando Rivadeneira

Olja Grgíc

Fjorda Koromani

Enisa Shevroja

Samuel Ghatan

Ruolin Li

Xinpeng He

profile picture of Haojie LuHaojie Lu

profile picture Jiawei LiJiawei Li

Artemis Gkitakou (Master student)

Danielle RatsmaDanielle Ratsma


Dr. Robert Kraaij

Djawad Radjabzadeh 


Prof. dr. Carola Zillikens

Laarschot-Denise-van-derDenise van de Laarschot

Jinluan Chen

Vivi Zhou

 Ariadne Bosman

Komal Waqas

profile picture of Tracey LuTracey Lu

Zografia ZervouZografia Zervou

 

Our research group is closely connected to the Human Genomics Facility, which provides services to internal and external customers.

Human Genomics Facility

Management:

Support:

Veen-Eline-vanEline van Veen (Secretariat)

Verkerk-Marijn_ITMarijn Verkerk (IT support)

profile picture Gaby van DijkDr. Gaby van Dijk (Projectmanagement)

Bio-informaticians:

Dr. Linda Broer 

Dr. Costanza L. Vallerga

Verlouw-JoostJoost Verlouw 

Vries-Jard-deJard de Vries

Lab technicians:

Jhamai-MilaMila Jhamai (Labmanagement)

Alawi-ZharaZara Alawi 

Arp-PascalPascal Arp

Buyukcelik-RamazanRamazan Buyukcelik

Sergio Chavez Chavez

Koet-ThomasThomas Koet 

Ramessersing-PawanPawan Ramessersing 

Verbiest-MichaelMichael Verbiest 

Wal-Pelle-van-derPelle van der Wal

Any questions or comments?

Please contact our office.

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