Jump to top menu Jump to main menu Jump to content
erlenmyer-research
Research group/lab  |  P.I. Professor dr. André Uitterlinden

Genetic Laboratory of Internal Medicine / Population Genomics

Our mission is to understand the genetics of complex traits and common diseases and apply the discoveries to clinical practice.

About our research group/lab

Our research

Research activities within the Genetic Laboratory of Internal Medicine / Population Genomics focus on genomics of complex diseases within large scale cohorts, such as the Rotterdam Study and Generation R. We have five research lines. Our research group is closely connected to the Human Genomics Facility, which provides services to internal and external customers.

Complex Diseases
(Professor dr. André Uitterlinden)

We study genetics and genomics of several common complex diseases and their risk factors, including endocrine and reproductive traits, and more in general ageing. We focus on bringing discoveries and genomic technology into the clinic.

Population Genomics of Locomotor Diseases and Ageing 
(Dr. Joyce van Meurs, UHD)

We study population genomics of age-related diseases, with a special focus on osteoarthritis and chronic pain. Focus is also on integrative genomics in population cohorts where multiple genomic levels are combined to understand and predict disease.

Translational Skeletal Genomics
(Professor dr. Fernando Rivadeneira)

We study the determinants of skeletal diseases along the life-course (with special focus on osteoporosis), seeking the translation of genomic discoveries into clinical applications. We do this by applying state-of-the art “big data” analytics integrating genomic functional assessments, imaging and other forms of medical data. 

Mendelian Genetics
(Dr. Annemieke Verkerk, UD)

We study monogenetic disease with Mendelian transmission and the population genetic context of pathogenic variations in disease genes. 

Microbiome Genomics
(Dr. Robert Kraaij, UD)

We study the microbial organisms in and on our body with next generation sequencing techniques, both in large cohort studies as well as in clinical settings. 

Our projects

Complex Diseases 
(Professor dr. André Uitterlinden)

GOALL In 2019 the Board of Directors endorsed this Genotyping on ALL patients (GOALL) project as a strategic goal within Erasmus MC. The project delivers tools, pipelines, and structures for using genetic information in the clinic such as polygenetic risk scores, Mendelian mutation panels, and pharmacogenetics. (Koers 23)

Pancare; SNP arrays. (EU FP7; with dr. Marry van den Heuvel-Eibrink) 2013-2017

VIRGO: ‘RSV host susceptibility’ 2012-2016

Population Genomics of Locomotor Diseases and Ageing 
(Dr. Joyce van Meurs, UHD)

VOILA. Vitality oriented lnnovation for the Lífecourse of the Ageing society (ZonMW)

FOCUM. (Reumafonds)

The interplay between MGP and VitK in the ethiology of osteoarthritis. We have recently identified MGP to be involved in osteoarthritis through a genome-wide association study. This project aims to elucidate how decreased function of MGP/ VitK affects cartilage/bone homeostasis and confers risk to osteoarthritis.(Reumafonds) 2017-2020

IFEROA. ldentification of the female specific etiology and risk groups for osteoarthritis (ZonMW-GENDER) 2017-2020

BBMRI: WP 2.0, DNA methylation  and RNA sequencing. 2016-2018

CHECK GWAS. (Reumafonds) 2015-2017

Prediction OA. (Reumafonds) 2014-2016

Translational Skeletal Genomics
(Professor dr. Fernando Rivadeneira)

GEMSTONE Genomics of Musculoskeletal Traits Translational Network - The project brings together a large international network of multidisciplinary experts seeking to translate genomic discoveries to the clinic.  (EU COST Action)

FIDELIO. Training network for research into bone Fragility In Diabetes across Europe: towards a personalized medicine approach (FIDELIO); one work package and two of the 12 ITN projects are coordinated by our group with special focus on genomic and gut microbiome research. (EU MARIE SKŁODOWSKA-CURIE ITN)

MRI/pQCT ERGO + GenR. (NWO VIDI) 2013-2018

Mendelian Genetics
(Dr. Annemieke Verkerk, UD)

Genetics of Lungfibrosis. (Coolsingelstichting;  with dr. Leonie Vergouw)

Atypical Femur Fractures. (NHMRC Australia; with professor dr. Carola Zillikens

Microbiome Genomics
(Dr. Robert Kraaij, UD)

Gut microbiome in dementia. (ZonMW-Memorabel)

Mrace MOVE. (Erasmus MC grant; with professor dr. Greet Vos)

Tailored Treat longinfectie; SNP arrays. (EU FP7) 2013-2017

Key Publications

We publish extensively in major scientific journals, mainly through our international collaborations in consortia which result in highly cited papers. Please see  publications in the profiles of our researchers.

Collaborations

Collaboration within Erasmus MC

We have strong historic ties with the department of Epidemiology, in the creation and conduction of the Rotterdam Study of elderly and the Generation R birth cohort, Erasmus MC Research Core Facilities). Furthermore, we closely collaborate with the departments of Clinical Genetics, Clinical Chemistry, Orthopedics, Radiology and Oral & Maxillofacial Surgery.

Collaboration outside of Erasmus MC

Most of our work takes place in large international consortia of collaborating investigators, several of which we have initiated ourselves (e.g., GEFOS, CHARGE, ReproGen, GO; see links below)

Funding & Grants

Complex Diseases 
(Professor dr. André Uitterlinden)

Koers 23

Population Genomics of Locomotor Diseases and Ageing 
(Dr. Joyce van Meurs, UHD)

Reumafonds

ZonMW-GENDER

ZonMW

Reumafonds

Translational Skeletal Genomics
(Professor dr. Fernando Rivadeneira)

EU COST Action

EU MARIE SKŁODOWSKA-CURIE ITN

Mendelian Genetics
(Dr. Annemieke Verkerk, UD)

Coolsingelstichting;  with dr. Leonie Vergouw

(NHMRC Australia; with professor dr. Carola Zillikens

Microbiome Genomics
(Dr. Robert Kraaij, UD)

ZonMW-Memorabel

Erasmus MC grant; with professor dr. Greet Vos

Career opportunities

Our group offers career opportunities for talented genomics researchers.  In addition we offer internships at academic and non-academic levels. Please inquire for vacancies or possibilities (e.vanveen@erasmusmc.nl).

 

Our team

Principal Investigators:

Support:

  • Eline van Veen (Secretariat)
  • Marijn Verkerk (IT support)

Postdocs:

PhD’s:

PhD students are listed under the different PI's.

Dr. Joyce van Meurs

  • Arjan Bergink
  • Bahar Sedaghatikhayat 
  • Ingrid Szilagyi
  • Lieke Kuiper


Professor dr. Fernando Rivadeneira

  • Enisa Shevroja
  • Fjorda Koromani 
  • Vid Prijatelj
  • Olja Grgic 
  • Sadaf Oliai Araghi 
  • Artemis Gkitakou
  • Sam Ghatan
  • Jiawei Li
  • Haojie
  • Tracey Lu
  • Rowling


Dr. Robert Kraaij

  • Djawad Radjabzadeh 


Professor dr. Carola Zillikens

  • Denise van de Laarschot 
  • Elizabeth Benz Inalaf  
  • Jinluan Chen
  • Komal Waqas
  • Vivi  Zhou 
  • Ariadne Bosman

 

Our research group is closely connected to the Human Genomics Facility, which provides services to internal and external customers.

Human Genomics Facility

Management:

Support:

  • Eline van Veen (Secretariat)
  • Marijn Verkerk (IT support)
  • Dr. Gaby van Dijk (Projectmanagement)

Bio-informaticians:

  • Dr. Linda Broer 
  • Dr. Costanza Valerga
  • Joost Verlouw 
  • Jard de Vries

Lab technicians:

  • Mila Jhamai (Labmanagement)
  • Zara Alawi 
  • Pascal Arp
  • Ramazan Buyukcelik
  • Sergio Chavez Chavez
  • Thomas Koet 
  • Pawan Ramessersing 
  • Michael Verbiest 
  • Pelle van der Wal

Any questions or comments?

Please contact our office.

Contact form