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research-project
Research project

Immune responses in neurodegenerative diseases: Protection or progression?

Status: Completed

We investigate brain immune cells (microglia) in zebrafish genetic models to gain insight in the roles of these cells in human brain diseases.

What we do

About our project

Background information

Microglia are involved in nearly all brain diseases, but it is unknown in what situation they protect against disease or rather promote disease.

Microglia

Overall aim

We aim to gain insight in the basic mechanisms and control of the microglia in the healthy brain and in the diseased brain.

Research method

We use in vivo imaging, genome editing and RNA sequencing in zebrafish models to find new disease mechanisms.

Desirable outcome

By understanding the roles of microglia, we will learn which of their actions to block or promote in disease.

Collaborations

Collaboration within Erasmus MC

  • Department of Genetic and Congenital Defects.
  • Department of Clinical Genetics.

Publications