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erlenmyer-research
Research group/lab

Energy Based Drug Delivery to the Skin

We investigate various energy-based devices including ablative fractional lasers and electronic pneumatic injection devices in order to optimize the delivery of drugs to the skin.

About our research group/lab

Our research

Why was this group formed?

Topical drugs have a very low absorption rate and therefore the bioavailability in the skin is only 1-5%. Some larger drug molecules are not absorbed at all and therefore have no efficacy when applied topically to the skin for dermatological indications. To overcome the main obstacle in the absorption op topical drugs, the stratum corneum, various energy-based devices can be employed such as ablative fractional lasers and electronic pneumatic injection devices.

Our aim is to improve patient care by developing and evaluating novel methods for drug delivery to the skin for various drugs and dermatological indications. 

 

What is the overall aim

We aim to improve efficacy and tolerability of topical treatments for various skin diseases using energy-based devices.

 

What type of research do we focus on in this group?

  • Pre-clinical research using porcine animal models (collaboration with the University op Kopenhagen)
  • Ex-vivo research on human and pig skin (collaboration with the University op Kopenhagen and Amsterdam University Medical Center)
Clinical trials with healthy volunteers and patients

Our projects

Key Publications

Bik L, Sangers T, Greveling K, Prens E, Haedersdal M, van Doorn M.

Efficacy and tolerability of intralesional bleomycin in dermatology: A systematic review [published online ahead of print, 2020 Feb 15]. J Am Acad Dermatol. 2020;S0190-9622(20)30226-7. doi:10.1016/j.jaad.2020.02.018

 

Bik L, van Doorn MBA, Biskup E, Ortner VK, Haedersdal M, Olesen UH.

Electronic Pneumatic Injection-Assisted Dermal Drug Delivery Visualized by Ex Vivo Confocal Microscopy [published online ahead of print, 2020 Jun 8]. Lasers Surg Med. 2020;10.1002/lsm.23279.

Collaborations

Collaboration within Erasmus MC

Department of Pathology

 

Collaboration outside of Erasmus MC

Dept. of Dermatology; Bispjebjerg Hospital, University of Kopenhagen

Dept. of Dermatology; Amsterdam University Medical Center (location AMC)

Technical University of Twente

Our team

Dr. Martijn van Doorn, dermatologist / clinical pharmacologist, PI, m.b.a.vandoorn@erasmusmc.nl

Prof. Errol Prens, dermatologist, e.prens@erasmusmc.nl

Dr. Jeffrey Damman, pathologist, j.damman@erasmusmc.nl

Principal Investigators

Project Leaders